{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:32:39Z","timestamp":1781105559042,"version":"3.54.1"},"reference-count":41,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacopsychiatry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute stress, potentially mediated by the stress-induced release of cortisol,\n                        affects decision-making processes. In the brain, cortisol activates two\n                        different types of receptors: the glucocorticoid receptor (GR) and the\n                        mineralocorticoid receptor (MR), each with different functional profiles.\n                        While previous studies suggest specific effects for MR and GR, the role of\n                        both receptor types in decision-making is insufficiently investigated.<\/jats:p>\n                  <jats:p>In this study, stress-induced effects of cortisol on decision-making\n                        processes were investigated after pharmacological receptor blockade of the\n                        MR (spironolactone, 300\u2009mg) or the GR (mifepristone, 600\u2009mg) in 318 healthy\n                        men (M=25.42, SD=5.01). After single-dose administration, participants were\n                        subjected to a social-evaluative stress task (Trier Social Stress Test,\n                        TSST), which reliably activates the HPA-axis, or a non-stressful control\n                        task (pTSST). Participants were randomly assigned to one study group:\n                        pTSST-placebo, TSST-placebo, TSST-spironolactone, or TSST-mifepristone.\n                        Subsequently, participants completed the Iowa Gambling Task (IGT) as an\n                        outcome measure. A mediation analysis was conducted to investigate direct\n                        effects of experimental manipulation in this study and indirect effects\n                        mediated by cortisol levels. The evidence for stress effects on decisions\n                        under ambiguity was positive.<\/jats:p>\n                  <jats:p>While stressed participants exhibited higher risk-taking, this was not the\n                        case in the TSST-spironolactone group, although this group had the most\n                        pronounced cortisol stress response. Thus, cortisol did not mediate this\n                        effect.<\/jats:p>\n                  <jats:p>The stress effect on decision-making was attenuated when MR was blocked. This\n                        corresponds to previous findings of increased risk-taking after MR\n                        activation and highlights a functional differentiation of both receptors for\n                        this domain.<\/jats:p>","DOI":"10.1055\/a-2646-7444","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:10:01Z","timestamp":1753315801000},"page":"44-51","source":"Crossref","is-referenced-by-count":1,"title":["Investigation of Stress-Induced Cortisol Effects on Decision Making\n                    After Pharmacological Mineralocorticoid or Glucocorticoid Receptor\n                    Blockade"],"prefix":"10.1055","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6880-5946","authenticated-orcid":false,"given":"Christian E","family":"Deuter","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie\n                    Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of\n                    Health, Klinik f\u00fcr Psychiatrie und Psychotherapie, Campus Benjamin Franklin,\n                    Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa-Svea","family":"Wei\u00df","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie\n                    Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of\n                    Health, Klinik f\u00fcr Psychiatrie und Psychotherapie, Campus Benjamin Franklin,\n                    Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linn K.","family":"Kuehl","sequence":"additional","affiliation":[{"name":"MSB (Medical School Berlin), Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Otte","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie\n                    Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of\n                    Health, Klinik f\u00fcr Psychiatrie und Psychotherapie, Campus Benjamin Franklin,\n                    Berlin, Germany"},{"name":"German Center for Mental Health (DZPG), partner site Berlin,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Wingenfeld","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie\n                    Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of\n                    Health, Klinik f\u00fcr Psychiatrie und Psychotherapie, Campus Benjamin Franklin,\n                    Berlin, Germany"},{"name":"German Center for Mental Health (DZPG), partner site Berlin,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/jnr.23521","article-title":"The impact of stress in decision making in the context of uncertainty","volume":"93","author":"P Morgado","year":"2015","journal-title":"J Neurosci Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1037\/bul0000060","article-title":"Effects of stress on decisions under uncertainty: A meta-analysis","volume":"142","author":"K Starcke","year":"2016","journal-title":"Psychol Bull"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1080\/10253890.2019.1593364","article-title":"Delayed effects of psychosocial stress on risk taking","volume":"22","author":"J 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