{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:09:46Z","timestamp":1780495786169,"version":"3.54.1"},"reference-count":110,"publisher":"Georg Thieme Verlag KG","issue":"05","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>Inherited antithrombin deficiency (ATD) is associated with a high risk of venous thromboembolic complications. Association of ATD with other conditions such as pregnancy obviously increases thromboembolic risk and may require anticoagulant therapy for prevention. Although there are several\/heterogenous international guidelines regarding thromboprophylaxis in pregnant patients with ATD, data on anticoagulant prophylaxis in this context are scarce in the literature. Thus, this situation remains a challenge both in the antepartum period and during delivery. Physicians from the French Society of Thrombosis and Haemostasis (SFTH) performed a review of the literature to suggest propositions regarding the management of thrombosis prevention based on anticoagulation and antithrombin substitution in ATD pregnant women. In this review, after reporting the thrombotic risk associated with ATD, the indication of anticoagulant therapy, its dosing regimen and monitoring, and the indication of antithrombin concentrates during pregnancy and the postpartum period are discussed as well as peripartum management. Finally, this work confirms the complex management of thrombotic prevention in pregnant patients with ATD. Indeed, it requires to take into account a multiplicity of features cited in our propositions that will hopefully provide some help in this field. This work also highlights the importance of multidisciplinary discussions for pregnant women with ATD who should be counseled in an expert center including hematologist, obstetrician, and anesthetist to optimize their management.<\/jats:p>","DOI":"10.1055\/a-2650-7959","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T12:42:04Z","timestamp":1752064924000},"page":"455-472","source":"Crossref","is-referenced-by-count":3,"title":["How to Manage Venous Thromboembolism Risk during Pregnancy in Patients with Inherited Antithrombin Deficiency?"],"prefix":"10.1055","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3946-2312","authenticated-orcid":false,"given":"Laetitia","family":"Mauge","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie biologique, AP HP, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, Inserm, PARCC, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Madar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bordeaux University Hospital, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Carr\u00e9","sequence":"additional","affiliation":[{"name":"Hematology Department, CHU de Poitiers, Poitiers, France"},{"name":"INSERM 1313 Ischemia Reperfusion, Metabolism, Aseptic Inflammation in Transplantation (IRMETIST), Universit\u00e9 de Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Fiore","sequence":"additional","affiliation":[{"name":"Laboratoire d'h\u00e9matologie H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque - CHU de Bordeaux, Pessac, France"},{"name":"Inserm U1034\u2013Biologie des Maladies Cardio-Vasculaires, Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4852-4738","authenticated-orcid":false,"given":"Nicolas","family":"Gendron","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie biologique, AP HP, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, Inserm, PARCC, Paris, France"},{"name":"F-CRIN INNOVTE, Saint-\u00c9tienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Mouton","sequence":"additional","affiliation":[{"name":"Laboratoire d'h\u00e9matologie H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque - CHU de Bordeaux, Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Proulle","sequence":"additional","affiliation":[{"name":"Service H\u00e9matologie Biologique, UF H\u00e9mostase clinique, H\u00f4pital Robert Debr\u00e9, CHU Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Suchon","sequence":"additional","affiliation":[{"name":"C2VN, INSERM, INRAE, Aix Marseille Univ, Marseille, France"},{"name":"Laboratory of Haematology, La Timone Hospital, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Trillot","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9mostase et Transfusion, CHU Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lechat","sequence":"additional","affiliation":[{"name":"Department of Gynecological and Obstetrical Anesthesiology, Bordeaux University Hospital, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Sentilhes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bordeaux University Hospital, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Macchi","sequence":"additional","affiliation":[{"name":"Hematology Department, CHU de Poitiers, Poitiers, France"},{"name":"INSERM 1313 Ischemia Reperfusion, Metabolism, Aseptic Inflammation in Transplantation (IRMETIST), Universit\u00e9 de Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On behalf of the TITAN group of the French Society of Thrombosis and Haemostasis (SFTH)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"issue":"04","key":"ref1","first-page":"185","article-title":"pour le comit\u00e9 national d'experts sur les mort maternelles (CNEMM)","volume":"52","author":"M Saucedo","year":"2024","journal-title":"Gynecol Obstet Fertil Senol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.thromres.2004.08.004","article-title":"Haemostatic changes in pregnancy","volume":"114","author":"B Brenner","year":"2004","journal-title":"Thromb Res"},{"issue":"19","key":"ref3","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1056\/NEJMra0707993","article-title":"Venous thromboembolic disease and pregnancy","volume":"359","author":"P E Marik","year":"2008","journal-title":"N Engl J Med"},{"issue":"14","key":"ref4","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1056\/NEJMoa1311485","article-title":"Risk of a thrombotic event after the 6-week postpartum period","volume":"370","author":"H Kamel","year":"2014","journal-title":"N Engl J Med"},{"issue":"04","key":"ref5","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/00006254-199904000-00023","article-title":"Deep vein thrombosis during pregnancy and the puerperium: a meta-analysis of the period of risk and the leg of presentation","volume":"54","author":"J G Ray","year":"1999","journal-title":"Obstet Gynecol Surv"},{"issue":"05","key":"ref6","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.ajog.2005.11.008","article-title":"Venous thromboembolism during pregnancy and the postpartum period: incidence, risk factors, and mortality","volume":"194","author":"A H James","year":"2006","journal-title":"Am J Obstet Gynecol"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"697","DOI":"10.7326\/0003-4819-143-10-200511150-00006","article-title":"Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study","volume":"143","author":"J A Heit","year":"2005","journal-title":"Ann Intern Med"},{"issue":"05","key":"ref8","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1055\/s-0037-1613887","article-title":"Incidence of venous thromboembolism: a community-based study in Western France. 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