{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:07:57Z","timestamp":1764806877982,"version":"3.46.0"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Adverse perinatal outcomes have been linked to alterations in vitamin\n                        D-binding protein (VDBP) levels. We assessed the predictive value of serum\n                        and cervicovaginal fluid VDBP for preterm birth, as well as to measure VDBP\n                        in threatened preterm labor (TPL) and preterm premature rupture of membranes\n                        (PPROM).<\/jats:p>\n                  <jats:p>A total of 138 pregnant women were divided into three groups in this\n                        prospective case-control study: TPL(n=59), PPROM (n=43) and control (n=36).\n                        Also, all patients were divided into two groups according to whether the\n                        latency period was shorter (n=48) or longer than 48 hours (n=90). The VDBP\n                        levels were measured using an enzyme-linked immunosorbent assay kit and\n                        compared between groups.<\/jats:p>\n                  <jats:p>Cervicovaginal fluid and serum VDBP levels were lower in the TPL and PPROM\n                        groups than controls. Cervicovaginal fluid VDBP&lt;0.63ng\/ml predicted\n                        preterm birth with 81.58% sensitivity and 53.23% specificity (AUC=0.713,\n                        p&lt;0.001). Serum VDBP\u2264 0.26ng\/ml predicted preterm birth with 61.84%\n                        sensitivity and 64.52% specificity (AUC=0.629, p=0.008). No significant\n                        difference was detected between serum and cervicovaginal fluid VDBP levels\n                        for predicting preterm birth (p=0.018). Moreover, cervicovaginal fluid\n                        VDBP&gt;0.44ng\/ml predicted latency period\u226448 hours with 43.75% sensitivity\n                        and 94.44% specificity (AUC=0.694, p&lt;0.001), while serum VDBP did not\n                        predict a latency period shorter than 48 hours (AUC=0.515, p=0.771).<\/jats:p>\n                  <jats:p>Both serum and cervicovaginal VDBP may be valuable markers for predicting\n                        preterm birth. Although no difference was found between serum and\n                        cervicovaginal VDBP in terms of predictive role, cervicovaginal fluid VDBP\n                        may be one step ahead of serum VDBP with the ability to predict a short\n                        latency period<\/jats:p>","DOI":"10.1055\/a-2650-9284","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:17:36Z","timestamp":1753229856000},"page":"403-408","source":"Crossref","is-referenced-by-count":0,"title":["The predictive role of maternal serum and cervicovaginal fluid\n                    vitamin D-binding protein for preterm birth and latency period"],"prefix":"10.1055","volume":"229","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6547-3990","authenticated-orcid":false,"given":"Ayten Nesibe","family":"Ozen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nevsehir State\n                    Hospital Hospital, Nevsehir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7888-7583","authenticated-orcid":false,"given":"Gulten","family":"Ozgen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, BursaYuksek Ihtisas Training\n                    and Research Hospital, University of Health Sciences, Bursa,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2697-7501","authenticated-orcid":false,"given":"Burcu","family":"Dincgez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, BursaYuksek Ihtisas Training\n                    and Research Hospital, University of Health Sciences, Bursa,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0070-2646","authenticated-orcid":false,"given":"Levent","family":"Ozgen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, BursaYuksek Ihtisas Training\n                    and Research Hospital, University of Health Sciences, Bursa,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1002\/ijgo.13195","article-title":"Global burden of preterm birth","volume":"150","author":"S R Walani","year":"2020","journal-title":"Int J Gynaecol Obstet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.2471\/BLT.08.062554","article-title":"The worldwide incidence of preterm birth: a systematic review of maternal\n                    mortality and morbidity","volume":"88","author":"S Beck","year":"2010","journal-title":"Bull World Health Organ"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e0198842","DOI":"10.1371\/journal.pone.0198842","article-title":"Vitamin D-binding protein in cervicovaginal fluid as a non-invasive predictor of\n                    intra-amniotic infection and impending preterm delivery in women with preterm\n                    labor or preterm premature rupture of membranes","volume":"13","author":"S Y Kook","year":"2018","journal-title":"PLoS ONE"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1159\/000504975","article-title":"First trimester protein biomarkers for risk of spontaneous preterm birth:\n                    identifying a critical need for more rigorous approaches to biomarker\n                    identification and validation","volume":"47","author":"A M D'Silva","year":"2020","journal-title":"Fetal Diagn Ther"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1177\/1933719116651149","article-title":"Measurement of interleukin 8 in cervicovaginal fluid in women with preterm\n                    premature rupture of membranes: A comparison of amniotic fluid samples","volume":"24","author":"E Y Jung","year":"2017","journal-title":"Reprod Sci"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1111\/aogs.12073","article-title":"Predictive value of combined cervicovaginal cytokines and gestational age at\n                    sampling for intra-amniotic infection in preterm premature rupture of\n                    membranes","volume":"92","author":"A Ryu","year":"2013","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1530\/REP-12-0264","article-title":"Proteomic analysis of human cervicovaginal fluid collected before preterm\n                    premature rupture of the fetal membranes","volume":"145","author":"S Liong","year":"2013","journal-title":"Reproduction"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3390\/nu14010090","article-title":"Upregulation of irisin and vitamin D-binding protein concentrations by\n                    increasing maternal 25-hydrovitamin d concentrations in combination with\n                    specific genotypes of vitamin D-binding protein polymorphisms","volume":"14","author":"S N Karras","year":"2021","journal-title":"Nutrients"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"E928","DOI":"10.1152\/ajpendo.00279.2012","article-title":"Expressions of vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1,\n                    and VDR in placentas from normal and preeclamptic pregnancies","volume":"303","author":"R Ma","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.2147\/IJWH.S436624","article-title":"Preterm birth: Screening and prediction","volume":"15","author":"L Creswell","year":"2023","journal-title":"Int J Womens Health"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1002\/ijgo.15514","article-title":"Prediction and prevention of preterm birth: Quality assessment and systematic\n                    review of clinical practice guidelines using the AGREE II framework","volume":"166","author":"A Ramachandran","year":"2024","journal-title":"Int J Gynaecol Obstet"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.15514","article-title":"Predictors of inflammation-mediated preterm birth","volume":"40","author":"H M Georges","year":"2025","journal-title":"Physiology (Bethesda)"},{"key":"ref13","first-page":"749","volume-title":"1\u03b1,25(OH)2 Vitamin D3, vitamin D nuclear receptor (VDR) and plasma\n                    vitamin D-binding protein (DBP) structures and ligand shape preferences for\n                    genomic and rapid biological responses. In: Bilezikian JP, Raisz LG, Martin TJ,\n                    eds. Principles of Bone Biology","author":"A W Norman","year":"2008"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1080\/14737159.2020.1699064","article-title":"Vitamin D-binding protein as a biomarker to confirm specific clinical\n                    diagnoses","volume":"20","author":"B Lisowska-Myjak","year":"2020","journal-title":"Expert Rev Mol Diagn"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.beem.2015.06.006","article-title":"Behind the scenes of vitamin D binding protein: more than vitamin D binding","volume":"29","author":"J R Delanghe","year":"2015","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.metabol.2017.10.001","article-title":"Understanding vitamin D metabolism in pregnancy: From physiology to\n                    pathophysiology and clinical outcomes","volume":"86","author":"S N Karras","year":"2018","journal-title":"Metabolism"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.3390\/nu12051489","article-title":"Vitamin D-binding protein in pregnancy and reproductive health","volume":"12","author":"M Fernando","year":"2020","journal-title":"Nutrients"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1186\/s12884-023-05636-z","article-title":"Vitamin D deficiency in pregnancy and the risk of preterm birth: a nested\n                    case-control study","volume":"23","author":"T Tahsin","year":"2023","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.placenta.2020.01.013","article-title":"Altered decidual and placental catabolism of vitamin D may contribute to the\n                    aetiology of spontaneous miscarriage","volume":"92","author":"H Hou","year":"2020","journal-title":"Placenta"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1262\/jrd.2013-096","article-title":"Alteration in the expression of proteins in unexplained recurrent pregnancy loss\n                    compared with in the normal placenta","volume":"60","author":"B Gharesi-Fard","year":"2014","journal-title":"J Reprod Dev"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"3956","DOI":"10.1038\/s41598-020-60924-4","article-title":"Proteinuria is associated with urinary loss of cubilin and vitamin D-binding\n                    protein in patients with preeclampsia","volume":"10","author":"M C Albejante","year":"2020","journal-title":"Sci Rep"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"5120267","DOI":"10.1155\/2017\/5120267","article-title":"Placental vitamin D-binding protein expression in human idiopathic fetal growth\n                    restriction","volume":"2017","author":"A F Wookey","year":"2017","journal-title":"J Pregnancy"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1021\/pr0605421","article-title":"Identification of novel protein biomarkers of preterm birth in human\n                    cervical-vaginal fluid","volume":"6","author":"L Pereira","year":"2007","journal-title":"J Proteome Res"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2650-9284.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:04:30Z","timestamp":1764806670000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2650-9284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,22]]},"references-count":23,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2025,12,3]]},"published-print":{"date-parts":[[2025,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2650-9284","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"type":"print","value":"0948-2393"},{"type":"electronic","value":"1439-1651"}],"subject":[],"published":{"date-parts":[[2025,7,22]]}}}