{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:04:06Z","timestamp":1789686246474,"version":"4.0.1"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"05","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Functional dyspepsia (FD) is common in children and refers to discomfort in\n                        the epigastric\/duodenal region, which cannot be explained by structural or\n                        biochemical abnormalities. Since the pathophysiology is still not fully\n                        understood, no guidelines in terms of treatment do exist.<\/jats:p>\n                  <jats:p>The aim of this study was to compare the therapeutical effect of plant\n                        extracts (STW-5) and acupressure in children with functional dyspepsia.<\/jats:p>\n                  <jats:p>This is a randomized, double-blind placebo-controlled trial. Before and after\n                        the allocated intervention of four weeks, participants had to fill in a\n                        cross-cultural validated questionnaire consisting of 52 questions to assess\n                        quality of life, as well as the extent of their discomfort (using a\n                        standardized visual analog scale (VAS)).<\/jats:p>\n                  <jats:p>33 patients were included in the study: 12 male and 21 female with an average\n                        age of 12.09 years (range: 7\u201317 years). Symptoms improved after four weeks\n                        of intervention in most treatment-groups: By 68% in children, who received\n                        STW-5, by 40% in the wristband (WB)- group and by 35% in the\n                        wrist-band-Placebo-group (WBPL). Patients receiving STW-5- Placebo showed\n                        even an increase of symptoms.<\/jats:p>\n                  <jats:p>This double-blind, placebo-controlled pilot study showed, that STW-5 and\/or\n                        anti-nausea wristbands are a cheap and effective option to treat children\n                        and teenagers suffering from functional dyspepsia.<\/jats:p>","DOI":"10.1055\/a-2652-1298","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T22:59:28Z","timestamp":1755817168000},"page":"272-279","source":"Crossref","is-referenced-by-count":0,"title":["The effect of anti-nausea wristbands and STW-5 in children suffering\n                    from dyspepsia \u2013 a randomized double-blind placebo-controlled\n                    pilot-study"],"prefix":"10.1055","volume":"238","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6972-542X","authenticated-orcid":false,"given":"Corinne","family":"L\u00e9geret","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, University Childrens Hospital Basel, Basel,\n                    Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Ludyga","sequence":"additional","affiliation":[{"name":"Department of Sports, Movement and Health, University of Basel, Basel,\n                    Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"D\u2019Aujourdhui","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina","family":"Schneider","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Hagmann","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"Acket","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"K\u00f6hler","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital, Kantonsspital Aarau, Aarau,\n                    Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Furlano","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, University Childrens Hospital Basel, Basel,\n                    Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"5087","DOI":"10.3390\/jcm10215087.","article-title":"Systematic Review of Pediatric Functional Gastrointestinal Disorders (Rome IV\n                    Criteria)","volume":"10","author":"A Vernon-Roberts","year":"2021","journal-title":"J Clin Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"151","DOI":"10.5056\/jnm16214.","article-title":"What Is New in Rome IV","volume":"23","author":"M J Schmulson","year":"2017","journal-title":"J Neurogastroenterol Motil"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"P1689","DOI":"10.1016\/S0140-6736(20)30469-4","article-title":"Functional dyspepsia","volume":"396","author":"A C Ford","year":"2020","journal-title":"The lancet"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e13573","DOI":"10.1111\/nmo.13573.","article-title":"Gut-focused hypnotherapy for Functional Gastrointestinal Disorders:\n                    Evidence-base, practical aspects, and the Manchester Protocol","volume":"31","author":"D H Vasant","year":"2019","journal-title":"Neurogastroenterol Motil"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e13984","DOI":"10.1111\/nmo.13984","article-title":"Effects of the herbal preparation STW 5-II on in vitro muscle activity in the\n                    guinea pig stomach","volume":"33","author":"M Schemann","year":"2021","journal-title":"Neurogastroenterol Motil"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e13984","DOI":"10.1111\/nmo.13984.","article-title":"Effects of the herbal preparation STW 5-II on in vitro muscle activity in the\n                    guinea pig stomach","volume":"33","author":"M Schemann","year":"2021","journal-title":"Neurogastroenterol Motil"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"102873","DOI":"10.1016\/j.ctim.2022.102873","article-title":"Functional gastrointestinal disorders in children: Effectivity, safety, and\n                    tolerability of the herbal preparation STW-5 (Iberogast\n                  \u00ae\n               )\n                    in general practice","volume":"71","author":"M Radke","year":"2022","journal-title":"Complementary Therapies in Medicine"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e0403123","DOI":"10.1128\/spectrum.04031-23.","article-title":"Rapid biotransformation of STW 5 constituents by human gut microbiome from IBS-\n                    and non-IBS donors","volume":"12","author":"T A Thumann","year":"2024","journal-title":"Microbiol Spectr"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"601","DOI":"10.3389\/fpsyt.2020.00601","article-title":"Herbal Therapies in Functional Gastrointestinal Disorders: A Narrative Review\n                    and Clinical Implication","volume":"11","author":"Y S Kim","year":"2020","journal-title":"Front. Psychiatry"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s10354-017-0578-y","article-title":"Early onset of efficacy in patients with functional and motility-related\n                    gastrointestinal disorders: A noninterventional study with\n                    Iberogast\u00ae. Fr\u00fchzeitiger Wirkungsbeginn bei Patienten mit\n                    funktionellen und motilit\u00e4tsbedingten gastrointestinalen Erkrankungen : Eine\n                    nichtinterventionelle Studie mit Iberogast\u00ae","volume":"168","author":"R Raedsch","year":"2018","journal-title":"Wien Med Wochenschr"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000485410","article-title":"STW 5 (Iberogast) Therapie in Gastrointestinal functional disorders","volume":"35","author":"P Malfertheiner","year":"2017","journal-title":"Dig Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/bja\/aei125","article-title":"Recent advances in the non-pharmacological management of postoperative nausea\n                    and vomiting","volume":"95","author":"D J Rowbotham","year":"2005","journal-title":"Br J Anaesth"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/BF03013905","article-title":"Post discharge nausea and vomiting after ambulatory laparoscopy is not reduced\n                    by promethazine prophylaxis","volume":"46","author":"J L Parlow","year":"1999","journal-title":"Can J Anesth"},{"key":"ref14","first-page":"Pages 645","volume":"11","author":"U Ravens-Sieberer","year":"2008","journal-title":"The KIDSCREEN-52 Quality of Life Measure for Children and\n                    Adolescents: Psychometric Results from a Cross-Cultural Survey in 13 European\n                    Countries; Value in Health"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"700","DOI":"10.3758\/s13414-020-02167-z.","article-title":"The arrow of time: Advancing insights into action control from the arrow version\n                    of the Eriksen flanker task","volume":"83","author":"K R Ridderinkhof","year":"2021","journal-title":"Atten Percept Psychophys"},{"key":"ref16","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"J Cohen","year":"1988"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/s41572-020-00222-5","article-title":"Paediatric functional abdominal pain disorders","volume":"6","author":"N Thapar","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e13538","DOI":"10.1111\/nmo.13538","article-title":"The role of psychological factors in pediatric functional abdominal pain\n                    disorders","volume":"31","author":"E Newton","year":"2019","journal-title":"Neurogastroenterol. Motil."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jpepsy\/jss131","article-title":"Individual and additive effects of mothers\u2019 and fathers\u2019 chronic pain on health\n                    outcomes in young adults with a childhood history of functional abdominal\n                    pain","volume":"38","author":"A L Sherman","year":"2013","journal-title":"J Pediatr Psychol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/j.pain.0000000000001085","article-title":"Social learning pathways in the relation between parental chronic pain and daily\n                    pain severity and functional impairment in adolescents with functional abdominal\n                    pain","volume":"159","author":"A L Stone","year":"2018","journal-title":"Pain"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1097\/j.pain.0000000000000185","article-title":"Social communication model of pain","volume":"156","author":"K D Craig","year":"2015","journal-title":"Pain"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e2020042101","DOI":"10.1542\/peds.2020-042101.","article-title":"Pharmacologic Treatment in Functional Abdominal Pain Disorders in Children: A\n                    Systematic Review","volume":"147","author":"R Rexwinkel","year":"2021","journal-title":"Pediatrics"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1177\/0009922810392773","article-title":"The prognostic value of obtaining a negative endoscopy in children with\n                    functional gastrointestinal disorders","volume":"50","author":"S Bonilla","year":"2011","journal-title":"Clin Pediatr (Phila)"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e13509","DOI":"10.1111\/nmo.13509","article-title":"Multiple psychological factors predict abdominal pain severity in children with\n                    irritable bowel syndrome","volume":"31","author":"J M Hollier","year":"2019","journal-title":"Neurogastroenterol. Motil."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"10886","DOI":"10.3390\/ijerph191710886","article-title":"Effect of Acupressure at P6 on Nausea and Vomiting in Women with Hyperemesis\n                    Gravidarum: A Randomized Controlled Trial","volume":"19","author":"N A Mohd Nafiah","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.ijnurstu.2017.02.014.","article-title":"Effects of acupressure on chemotherapy-induced nausea and vomiting-a systematic\n                    review with meta-analyses and trial sequential analysis of randomized controlled\n                    trials","volume":"70","author":"J Miao","year":"2017","journal-title":"Int J Nurs Stud"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"Pages e85","DOI":"10.1016\/j.bja.2022.06.028","article-title":"Wearable transcutaneous electrical acupoint stimulation bracelet for prevention\n                    of postoperative nausea and vomiting in patients undergoing hysteroscopic\n                    surgery: a randomised controlled trial","volume":"129","author":"Wang Na","year":"2022","journal-title":"British Journal of Anaesthesia"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"101238","DOI":"10.1016\/j.conctc.2023.101238.","article-title":"The impact of using P6 acupressure on the nausea, vomiting, and comfort of\n                    myocardial infarction patients: A randomized, single-blind, placebo-controlled\n                    clinical trial","volume":"36","author":"S Afshar","year":"2023","journal-title":"Contemp Clin Trials Commun"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1097\/j.pain.0000000000000800.","article-title":"Brief telephone-delivered cognitive behavioral therapy targeted to parents of\n                    children with functional abdominal pain: a randomized controlled trial","volume":"158","author":"R L Levy","year":"2017","journal-title":"Pain"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s10354-012-0169-x.","article-title":"STW 5 (Iberogast\u00ae) \u2013 a safe and effective standard in the treatment\n                    of functional gastrointestinal disorders","volume":"163","author":"B Ottillinger","year":"2013","journal-title":"Wien Med Wochenschr"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1186\/s12906-021-03337-8","article-title":"Effect of the standard herbal preparation, STW5, treatment on dysbiosis induced\n                    by dextran sodium sulfate in experimental colitis","volume":"21","author":"S S Mohamed","year":"2021","journal-title":"BMC Complement Med Ther"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1080\/17512433.2018.1540298.","article-title":"Pharmacological treatments for functional nausea and functional dyspepsia in\n                    children: a systematic review","volume":"11","author":"P D Browne","year":"2018","journal-title":"Expert Rev Clin Pharmacol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"54","DOI":"10.5056\/jnm23014.","article-title":"The Effect of STW5 (Iberogast) on Reflux Symptoms in Patients With Concurrent\n                    Dyspeptic Symptoms: A Double-blind Randomized Placebo-controlled Crossover\n                    Trial","volume":"30","author":"RA B Oude Nijhuis","year":"2024","journal-title":"J Neurogastroenterol Motil"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"102873","DOI":"10.1016\/j.ctim.2022.102873","article-title":"Functional gastrointestinal disorders in children: Effectivity, safety, and\n                    tolerability of the herbal preparation STW-5 (Iberogast\n                  \u00ae\n               )\n                    in general practice","volume":"71","author":"M Radke","year":"2022","journal-title":"Complementary Therapies in Medicine"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1080\/24740527.2019.1577679","article-title":"Parents\u2019 experiences with pediatric chronic pain","volume":"3","author":"A Le","year":"2019","journal-title":"Can J Pain"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s40359-020-00430-4","article-title":"How do mothers of adolescents with chronic pain experience their own quality of\n                    life?","volume":"8","author":"S Skarstein","year":"2020","journal-title":"BMC Psychol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1287343","DOI":"10.3389\/fped.2024.1287343.","article-title":"Parent-perceived recurrent pain in children: associations with maternal pain,\n                    depressiveness, socioeconomic status, and children\u2019s behavioural\n                    difficulties","volume":"12","author":"L Petri","year":"2024","journal-title":"Front Pediatr"}],"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2652-1298.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:30:52Z","timestamp":1789684252000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2652-1298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,21]]},"references-count":37,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2026,9,17]]},"published-print":{"date-parts":[[2026,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2652-1298","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"value":"0300-8630","type":"print"},{"value":"1439-3824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,21]]}}}