{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T23:51:35Z","timestamp":1764719495024,"version":"3.46.0"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Metastasectomy is a recommended and widely used operation for pulmonary metastases from colorectal cancer (CRC). The main disadvantage of pulmonary metastasectomy is the high rate of metastasis recurrence, which occurs in almost half of patients. To suppress residual pulmonary microfoci, isolated lung chemoperfusion (ILuP) is used, but its effectiveness has not been studied.<\/jats:p>\n                  <jats:p>The results of pulmonary metastasectomy were studied in 160 patients. In 65 patients of the main group, open metastasectomy with isolated chemoperfusion of the lungs was performed; in 95 patients of the control group, standard open or thoracoscopic metastasectomy was performed. The study design included 1:1 pseudorandomization using the nearest neighbor method. For 17 patients who underwent standard metastasectomy and then metastasectomy with ILuP for recurrent pulmonary metastases, these patients themselves were used as the nearest neighbor. For the remaining patients, the matching pairs were selected by the Propensity Score Matching method. After balancing the sample, the main and control groups comprised 41 pairs of observations, which were subjected to further analysis with assessment of relapse-free pulmonary survival according to Kaplan\u2013Meier. Factors influencing survival were studied in the Cox's model.<\/jats:p>\n                  <jats:p>The median recurrence-free survival in patients of the main group who underwent metastasectomy with ILuP was 22.3 months versus 9.1 months in the control group. One-year recurrence-free survival in the main group was 77.5\u2009\u00b1 \u20096.6% versus 38.1\u2009\u00b1\u20099.1% in the control group.<\/jats:p>\n                  <jats:p>Isolated lung chemoperfusion increases median recurrence-free survival after pulmonary metastasectomy by more than one year for colorectal cancer.<\/jats:p>","DOI":"10.1055\/a-2652-7957","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T01:33:15Z","timestamp":1752283995000},"page":"661-665","source":"Crossref","is-referenced-by-count":0,"title":["Lung Chemoperfusion Improves Relapse-Free Survival after Metastasectomy for Colorectal Cancer"],"prefix":"10.1055","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3837-2515","authenticated-orcid":false,"given":"Evgeny","family":"Levchenko","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology, N.N. Petrov National Medical Research Center of Oncology, Pesochny, Saint Petersburg, Russia"},{"name":"Department of Oncology, I.I. Mechnikov North-Western State Medical University, Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9968-299X","authenticated-orcid":false,"given":"Mikhail","family":"Klochkov","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology, State Budgetary Healthcare Institution of Stavropol Region (Stavropol regional Clinical Oncological dispensary), Stavropol, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8761-4467","authenticated-orcid":false,"given":"Alexander","family":"Mikhnin","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology, N.N. Petrov National Medical Research Center of Oncology, Pesochny, Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7744-8135","authenticated-orcid":false,"given":"Nikita","family":"Levchenko","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology, N.N. Petrov National Medical Research Center of Oncology, Pesochny, Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9596-4835","authenticated-orcid":false,"given":"Stepan","family":"Ergnyan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology, N.N. Petrov National Medical Research Center of Oncology, Pesochny, Saint Petersburg, Russia"},{"name":"Department of Oncology, I.P. Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9051-2637","authenticated-orcid":false,"given":"Oleg","family":"Mamontov","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology, N.N. Petrov National Medical Research Center of Oncology, Pesochny, Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3226-429X","authenticated-orcid":false,"given":"Viktoriia","family":"Shabinskaya","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology, N.N. Petrov National Medical Research Center of Oncology, Pesochny, Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.athoracsur.2018.10.028","article-title":"Expert consensus document on pulmonary metastasectomy","volume":"107","author":"J R Handy","year":"2019","journal-title":"Ann Thorac Surg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"913678","DOI":"10.3389\/fsurg.2022.913678","article-title":"Lung metastasectomy from colorectal cancer, 10-year experience in a South American Cancer Center","volume":"9","author":"C Carvajal","year":"2022","journal-title":"Front Surg"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1186\/s13019-021-01740-3","article-title":"Survival prognostic and recurrence risk factors after single pulmonary metastasectomy","volume":"16","author":"C Forster","year":"2021","journal-title":"J Cardiothorac Surg"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S0022-5223(96)70043-0","article-title":"Isolated lung perfusion with platinum in the treatment of pulmonary metastases from soft tissue sarcomas","volume":"112","author":"G B Ratto","year":"1996","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"06","key":"ref5","first-page":"960","article-title":"[Immediate results of isolated chemoperfusion of the lung with melphalan and cisplatin in combination with metastasectomy in treatment for resectable metastatic lung lesions]","volume":"61","author":"E V Levchenko","year":"2015","journal-title":"Vopr Onkol"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1186\/s13063-019-3837-y","article-title":"Pulmonary metastasectomy versus continued active monitoring in colorectal cancer (PulMiCC): a multicentre randomised clinical trial","volume":"20","author":"T Treasure","year":"2019","journal-title":"Trials"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1111\/codi.15113","article-title":"Pulmonary metastasectomy in colorectal cancer: Updated analysis of 93 randomized patients - control survival is much better than previously assumed","volume":"22","author":"M Milosevic","year":"2020","journal-title":"Colorectal Dis"},{"issue":"19","key":"ref8","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1002\/(SICI)1097-0258(19981015)17:19<2265::AID-SIM918>3.0.CO;2-B","article-title":"Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group","volume":"17","author":"R B D'Agostino Jr","year":"1998","journal-title":"Stat Med"},{"issue":"04","key":"ref9","doi-asserted-by":"crossref","first-page":"707","DOI":"10.37469\/0507-3758-2024-70-4-707-716","article-title":"Surgical treatment of pulmonary metastases in colorectal cancer. The impact of isolated lung chemoperfusion on disease-free survival (in the lung)","volume":"70","author":"E V Levchenko","year":"2024","journal-title":"Vopr Onkol"},{"issue":"04","key":"ref10","first-page":"69","article-title":"Reducing bias in cancer research: application of propensity score matching","volume":"29","author":"B B Reeve","year":"2008","journal-title":"Health Care Financ Rev"}],"container-title":["The Thoracic and Cardiovascular Surgeon"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2652-7957.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T23:47:56Z","timestamp":1764719276000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2652-7957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,11]]},"references-count":10,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2025,12,2]]},"published-print":{"date-parts":[[2025,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2652-7957","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0171-6425","1439-1902"],"issn-type":[{"type":"print","value":"0171-6425"},{"type":"electronic","value":"1439-1902"}],"subject":[],"published-other":{"date-parts":[[2025,7,11]]},"published":{"date-parts":[[2025,7,11]]}}}