{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:58:08Z","timestamp":1768517888259,"version":"3.49.0"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"12","funder":[{"name":"Changchun University of Chinese Medicine","award":["S202310199014"],"award-info":[{"award-number":["S202310199014"]}]},{"name":"Jilin Medical Products Administration, China","award":["JLPZGF-2020-081"],"award-info":[{"award-number":["JLPZGF-2020-081"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n               Kalopanax septemlobus (K. septemlobus) has been documented for therapeutic efficacy against scabies, but with fewer modern studies. In this paper, the inhibitory effects of K. semtemlobus extract and monomeric compounds on Trichophyton mentagrophytes and Trichophyton rubrum were studied, and the mechanism of action was preliminarily discussed. The chemical constituents of the ethyl acetate layer of K. semtemlobus were isolated and purified under the trace of antifungal activity (microdilution method). The structure was characterized by nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS); in vitro antifungal activity was investigated by microdilution (MIC, MFC), spore germination suppression, serum induced culture, extracellular protein determination, intracellular nucleic acid release, and PI fluorescence staining. Two compounds were isolated and elucidated, hederagenin (1) and kalopanaxsaponin A\n          (2), respectively. The antifungal study showed that kalopanaxsaponin A had strong activity and could inhibit fungal growth from growth appreciation, transformation, and cell membrane (protein, nucleic acid leakage). The above data show that kalopanaxsaponin A has a strong antifungal effect (MIC50=7.8\u2009\u00b5g\/mL), but in vivo and clinical experiments are needed to verify whether it has a curative effect. This study provides a potential compound for the development of natural antifungal drugs.<\/jats:p>","DOI":"10.1055\/a-2654-9361","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T22:48:59Z","timestamp":1754434139000},"page":"690-700","source":"Crossref","is-referenced-by-count":1,"title":["The Antifungal Activity and Potential Mechanism of Kalopanax septemlobus against Trichophyton mentagrophytes and T. rubrum"],"prefix":"10.1055","volume":"91","author":[{"given":"Wei","family":"Liu","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun, Jilin, China"},{"name":"College of Health and Welfare, Changchun Humanities and Sciences College, Changchun, Jilin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyi","family":"Yang","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun, Jilin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun, Jilin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun, Jilin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuling","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun, Jilin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun, Jilin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1134\/S1022795421060132","article-title":"Genetic diversity of Kalopanax septemlobus (Thunb.) 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Kim","year":"1998","journal-title":"Arch Pharm Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"02844","DOI":"10.3389\/fmicb.2019.02844","article-title":"Anticandidal activity of kalopanaxsaponin A: Effect on proliferation, cell morphology, and key virulence attributes of Candida albicans","volume":"10","author":"Y Li","year":"2019","journal-title":"Front Microbiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e0243066","DOI":"10.1371\/journal.pone.0243066","article-title":"Kalopanaxsaponin A induces reactive oxygen species mediated mitochondrial dysfunction and cell membrane destruction in Candida albicans","volume":"15","author":"R A Khalaf","year":"2020","journal-title":"PLoS One"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"457","DOI":"10.4062\/biomolther.2012.20.5.457","article-title":"Kalopanaxsaponin B ameliorates TNBS-induced colitis in mice","volume":"20","author":"J J Jeong","year":"2012","journal-title":"Biomol Ther"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4110\/in.2010.10.6.212","article-title":"The stem bark of Kalopanax pictus exhibits anti-inflammatory effect through heme oxygenase-1 induction and NF-\u03baB suppression","volume":"10","author":"S Y Bang","year":"2010","journal-title":"Immune Netw"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"100504","DOI":"10.1016\/j.hermed.2021.100504","article-title":"Immunostimulatory activity of stem bark of Kalopanax pictus in RAW 264.7 macrophage","volume":"32","author":"S Kim","year":"2022","journal-title":"J Herb Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1248\/bpb.26.429","article-title":"Antiinflammatory activity of a-hederin methyl ester from the alkaline hydrolysate of the butanol fraction of Kalopanax pictus bark extract","volume":"26","author":"D W Li","year":"2003","journal-title":"Biol Pharm 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