{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:33:21Z","timestamp":1783550001358,"version":"3.55.0"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"CP","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82170555, 82270569, 82000507"],"award-info":[{"award-number":["82170555, 82270569, 82000507"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Endoscopic resection for duodenal gastrointestinal stromal tumors (GISTs) is still considered a great challenge with a high risk of complications. This study aimed to evaluate effectiveness and safety of endoscopic resection for duodenal GIST.<\/jats:p><jats:p>Between June 2013 and August 2024, we performed a retrospective study of patients with duodenal GISTs who underwent endoscopic resection at Zhongshan Hospital. Data on patient characteristics, clinical outcome, and follow-up were collected.<\/jats:p><jats:p>A total of 73 patients with duodenal GISTs were enrolled, including 31 patients who underwent endoscopic submucosal dissection (ESD) and 42 who underwent endoscopic full-thickness resection (EFTR). Mean lesion size was 1.2 \u00b1 0.5 cm and 1.9 \u00b1 0.9 cm, respectively. En bloc resection rates were 96.8% and 95.2%, respectively. Rates of R0 resection were 45.2% and 42.9%, respectively. Rates of R1 resection were 54.8% and 57.1%, respectively. No patient transferred to open surgery. Postoperative adverse events included delayed bleeding (1 case), delayed perforation (1 case), delayed wall edema (2 cases), hydrothorax (1 case), and retroperitoneal infection (1 case). Mean hospital stays were 4.1 \u00b1 2.8 days and 6.2 \u00b1 4.9 days, respectively. No metastasis or duodenal stenosis were detected during the follow-up period (64.8 \u00b1 43.6 months and 61.3 \u00b1 40.2 months, respectively). Local recurrence occurred in one patient with high recurrence risk at 56 months after EFTR.<\/jats:p><jats:p>ESD and EFTR are safe, minimally invasive treatments for duodenal GISTs. Moreover, the EFTR technique may have advantages of completely resecting lesions originating from the deep muscularis propria layer, particularly lesions with extraluminal growth.<\/jats:p>","DOI":"10.1055\/a-2655-1439","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:07Z","timestamp":1752537607000},"source":"Crossref","is-referenced-by-count":1,"special_numbering":"S","title":["Feasibility and safety of endoscopic resection for\u00a0duodenal gastrointestinal stromal tumors"],"prefix":"10.1055","volume":"13","author":[{"given":"Shao-Bin","family":"Luo","sequence":"additional","affiliation":[{"name":"Endoscopy Center and Edoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China"},{"name":"Shanghai Collaborative Innovation Center of Endoscopy, Shanghai, 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zu-Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Endoscopy Center and Edoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China"},{"name":"Shanghai Collaborative Innovation Center of Endoscopy, Shanghai, 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Endoscopy Center and Edoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China"},{"name":"Shanghai Collaborative Innovation Center of Endoscopy, Shanghai, 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Qun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Endoscopy Center and Edoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China"},{"name":"Shanghai Collaborative Innovation Center of Endoscopy, Shanghai, 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Yan","family":"Cai","sequence":"additional","affiliation":[{"name":"Endoscopy Center and Edoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China"},{"name":"Shanghai Collaborative Innovation Center of Endoscopy, Shanghai, 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan-Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Endoscopy Center and Edoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China"},{"name":"Shanghai Collaborative Innovation Center of Endoscopy, Shanghai, 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-Hong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Endoscopy Center and Edoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China"},{"name":"Shanghai Collaborative Innovation Center of Endoscopy, Shanghai, 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"vi136","DOI":"10.1093\/annonc\/mdm243","article-title":"Gastrointestinal stromal tumors (GISTs): focus on histopathological diagnosis and biomolecular features","volume":"18","author":"G Badalamenti","year":"2007","journal-title":"Ann Oncol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41572-021-00254-5","article-title":"Gastrointestinal stromal tumours","volume":"7","author":"JY Blay","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1097\/PAP.0000000000000166","article-title":"Surgical pathology of gastrointestinal stromal tumors: practical implications of morphologic and molecular heterogeneity for precision medicine","volume":"24","author":"GW Charville","year":"2017","journal-title":"Adv Anat Pathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1200\/JCO.2014.59.7344","article-title":"GI stromal tumors: 15 years of lessons from a rare cancer","volume":"33","author":"A Cioffi","year":"2015","journal-title":"J Clin Oncol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1055\/a-2369-7854","article-title":"A subepithelial lesion algorithm for endoscopic (SAFE) resection in the upper gastrointestinal tract","volume":"57","author":"S Gupta","year":"2025","journal-title":"Endoscopy"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.gie.2023.06.009","article-title":"Endoscopic full-thickness resection versus endoscopic submucosal dissection for challenging colorectal lesions: a randomized trial","volume":"98","author":"G Andrisani","year":"2023","journal-title":"Gastrointest 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