{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:36:28Z","timestamp":1790145388082,"version":"4.0.1"},"reference-count":95,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lupus anticoagulant-hypoprothrombinemia syndrome (LAHS) is a rare hemorrhagic disorder that should be differentiated from classical antiphospholipid syndrome. Literature review shows that LAHS may affect people at any age but approximately 40% are children younger than 10 years. Autoimmune and infectious diseases are the most frequent triggering causes, and the laboratory profile is characterized by a prolongation of prothrombin time (PT) and activated partial thromboplastin time (aPTT) with a mild to severe reduction in factor II levels. In more than half the patients, the other coagulation factors are normal, while anti-cardiolipin and anti-\u03b22-glycoprotein I antibodies show a high titer. Lupus anticoagulant (LA) is positive in 100% of cases, as this represents a defining feature. The majority of patients have mucocutaneous bleeding events (44%); cerebral bleeding can occur in 10% of patients and other common bleeding sites are the gastrointestinal and genitourinary tracts. There is no standard treatment for LAHS. Supportive measures, such as fresh frozen plasma, packed red blood, and platelet transfusion, are frequently administered in association with steroids alone or in combination with intravenous immunoglobulin or cyclophosphamide, azathioprine, and rituximab. Death, recurrent bleeding, and thrombosis can occur in approximately 3, 13, and 14% of patients, respectively. Our patient was an old man with a myocardial infarction and a systemic infection from Candida parapsilosis. Thrombin generation and clot waveform analysis were performed before and after treatment. Thrombin generation better reflected the role of prothrombin, revealing that a factor II value of below around 15% can represent a risk for major bleeding. Treatment with methylprednisolone and three-factor human prothrombin complex concentrate allowed the patient to reach a complete recovery 1 month after initial diagnosis.<\/jats:p>","DOI":"10.1055\/a-2657-6291","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T22:40:07Z","timestamp":1753483207000},"page":"304-314","source":"Crossref","is-referenced-by-count":1,"title":["Lupus Anticoagulant-hypoprothrombinemia Syndrome: A Review Enriched by a New Particular Patient"],"prefix":"10.1055","volume":"52","author":[{"given":"Doris","family":"Barcellona","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero-Universitaria of Cagliari, Cagliari, Italy"},{"name":"Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy"},{"name":"Fondazione Arianna, Anticoagulazione.it, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Mameli","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero-Universitaria of Cagliari, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Montisci","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero-Universitaria of Cagliari, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Filomena","family":"Ruberto","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero-Universitaria of Cagliari, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Fenu","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero-Universitaria of Cagliari, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Marongiu","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero-Universitaria of Cagliari, Cagliari, Italy"},{"name":"Department of Medical Science and Public Health, Fondazione Arianna, Anticoagulazione.it, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1182\/blood-2002-02-0441","article-title":"Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature","volume":"101","author":"M Galli","year":"2003","journal-title":"Blood"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1182\/blood.V61.4.684.684","article-title":"A mechanism for the hypoprothrombinemia of the acquired hypoprothrombinemia-lupus anticoagulant syndrome","volume":"61","author":"S P 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Tripodi","year":"2020","journal-title":"Haematologica"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.5858\/arpa.2023-0453-RA","article-title":"Clot waveform analysis: from hypercoagulability to hypocoagulability: a review","volume":"148","author":"F Marongiu","year":"2024","journal-title":"Arch Pathol Lab Med"},{"issue":"07","key":"ref10","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/jth.12287","article-title":"Towards standardization of clot waveform analysis and recommendations for its clinical applications","volume":"11","author":"M Shima","year":"2013","journal-title":"J Thromb Haemost"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1055\/s-0038-1657690","article-title":"Properties of optical data from activated partial thromboplastin time and prothrombin time assays","volume":"78","author":"P J Braun","year":"1997","journal-title":"Thromb 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Chumsky","year":"2023","journal-title":"Clin Rheumatol"},{"issue":"03","key":"ref34","first-page":"149","article-title":"Lupus anticoagulant-hypoprothrombinemia in healthy adult","volume":"23","author":"C H Chung","year":"2008","journal-title":"Korean J Intern Med (Korean Assoc Intern Med)"},{"issue":"04","key":"ref35","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1001\/archpedi.1970.02100050367019","article-title":"Incoagulability of the blood in systemic lupus erythematosus. A case due to hypoprothrombinemia and a circulating anticoagulant","volume":"119","author":"J J Corrigan Jr","year":"1970","journal-title":"Am J Dis Child"},{"issue":"02","key":"ref36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/ajcp\/107.2.197","article-title":"A new method for characterization and epitope determination of a lupus anticoagulant-associated neutralizing antiprothrombin antibody","volume":"107","author":"H CF C\u00f4t\u00e9","year":"1997","journal-title":"Am J Clin Pathol"},{"issue":"04","key":"ref37","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1440-1754.2007.01065.x","article-title":"Bruising: when it is spontaneous and not idiopathic thrombocytopenia purpura","volume":"43","author":"A L Davey","year":"2007","journal-title":"J Paediatr Child Health"},{"issue":"02","key":"ref38","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1055\/s-0037-1614466","article-title":"Acquired hypoprothrombinemia related to high titres of antiprotein-phospholipid antibodies","volume":"81","author":"G de Larra\u00f1aga","year":"1999","journal-title":"Thromb Haemost"},{"issue":"01","key":"ref39","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/0049-0172(94)90095-7","article-title":"Hypoprothrombinemia in childhood systemic lupus erythematosus","volume":"24","author":"A Eberhard","year":"1994","journal-title":"Semin Arthritis Rheum"},{"issue":"07","key":"ref40","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1191\/096120399678840846","article-title":"Lupus anticoagulant-hypoprothrombinemia syndrome associated with systemic lupus erythematosus: report of 2 cases and review of literature","volume":"8","author":"D Erkan","year":"1999","journal-title":"Lupus"},{"issue":"03","key":"ref41","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1055\/s-0038-1653448","article-title":"Antiprothrombinase and factor II deficiency in a non SLE patient","volume":"46","author":"G Follea","year":"1981","journal-title":"Thromb Haemost"},{"issue":"06","key":"ref42","doi-asserted-by":"crossref","first-page":"e26357","DOI":"10.1002\/pbc.26357","article-title":"Lupus anticoagulant hypoprothrombinemia syndrome associated with severe thrombocytopenia in a child","volume":"64","author":"A Foord","year":"2017","journal-title":"Pediatr Blood Cancer"},{"issue":"05","key":"ref43","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/MBC.0000000000000545","article-title":"Lupus anticoagulant-hypoprothrombinemia syndrome and catastrophic antiphospholipid syndrome in a patient with antidomain I antibodies","volume":"27","author":"J Galland","year":"2016","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"07","key":"ref44","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1177\/0961203317751853","article-title":"Rituximab use in pediatric lupus anticoagulant hypoprothrombinemia syndrome\u2014report of three cases and review of the literature","volume":"27","author":"K Cetin Gedik","year":"2018","journal-title":"Lupus"},{"issue":"01","key":"ref45","first-page":"85","article-title":"Prothrombin deficiency and hemorrhage associated with a lupus anticoagulant","volume":"54","author":"E Grau","year":"1997","journal-title":"Am J Hematol"},{"issue":"04","key":"ref46","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00277-012-1600-5","article-title":"Lupus anticoagulant hypoprothrombinemia syndrome in Bence-Jones protein \u03ba-type multiple myeloma patient with phosphatidylserine-dependent antiprothrombin antibody","volume":"92","author":"Y Hara","year":"2013","journal-title":"Ann Hematol"},{"issue":"04","key":"ref47","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/rheumatology\/30.4.308","article-title":"Acquired hypoprothrombinaemia and lupus anticoagulant: response to steroid therapy","volume":"30","author":"R J Hift","year":"1991","journal-title":"Br J Rheumatol"},{"issue":"01","key":"ref48","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1177\/096120339700600110","article-title":"Catastrophic haemorrhage in a case of paediatric primary antiphospholipid syndrome and factor II deficiency","volume":"6","author":"N Hudson","year":"1997","journal-title":"Lupus"},{"issue":"05","key":"ref49","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.1111\/apa.12171","article-title":"A coeliac child presenting with bleeding","volume":"102","author":"G Indolfi","year":"2013","journal-title":"Acta Paediatr"},{"issue":"02","key":"ref50","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF01788133","article-title":"Transient lupus anticoagulant associated with hypoprothrombinemia and factor XII deficiency following adenovirus infection","volume":"67","author":"U Jaeger","year":"1993","journal-title":"Ann 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Ed)"},{"issue":"08","key":"ref59","doi-asserted-by":"crossref","first-page":"3000605221115390","DOI":"10.1177\/03000605221115390","article-title":"Autoimmune hemolytic anemia as an initial presentation in children with systemic lupus erythematosus: two case reports","volume":"50","author":"Y Lu","year":"2022","journal-title":"J Int Med Res"},{"issue":"04","key":"ref60","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00277-014-2245-3","article-title":"Activated partial thromboplastin time sensitivity to lupus anticoagulant in a patient with transient arthritis and lupus anticoagulant-hypoprothrombinemia syndrome","volume":"94","author":"L Mauge","year":"2015","journal-title":"Ann Hematol"},{"issue":"05","key":"ref61","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/MD.0b013e31826b971f","article-title":"Lupus anticoagulant-hypoprothrombinemia syndrome: report of 8 cases and review of the literature","volume":"91","author":"K Mazodier","year":"2012","journal-title":"Medicine (Baltimore)"},{"issue":"01","key":"ref62","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1055\/s-0038-1624567","article-title":"Anaphylaxis following human prothrombin complex concentrate in a child with lupus anticoagulant hypoprothrombinemia syndrome: a cautionary tale","volume":"2","author":"H Mediwake","year":"2018","journal-title":"TH Open"},{"issue":"02","key":"ref63","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s11239-019-01955-1","article-title":"A case report of severe bleeding due to lupus anticoagulant hypoprothrombinemia syndrome","volume":"49","author":"E Meireles","year":"2020","journal-title":"J Thromb Thrombolysis"},{"issue":"07","key":"ref64","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s00431-006-0117-0","article-title":"Transient antiphospholipid antibodies associated with acute infections in children: a report of three cases and a review of the 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Ozdel","year":"2020","journal-title":"J Obstet Gynaecol"},{"issue":"02","key":"ref71","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1111\/hae.12027","article-title":"Resolution of hypoprothrombinemia-lupus anticoagulant syndrome (HLAS) after multidrug therapy with rituximab: a case report and review of the literature","volume":"19","author":"R D Paschal","year":"2013","journal-title":"Haemophilia"},{"issue":"05","key":"ref72","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/00000441-199405000-00007","article-title":"Case report: the lupus anticoagulant-hypoprothrombinemia syndrome","volume":"307","author":"N W Peacock","year":"1994","journal-title":"Am J Med Sci"},{"issue":"01","key":"ref73","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1055\/s-0040-1705091","article-title":"Prothrombin is responsible for the lupus cofactor phenomenon in a patient with lupus anticoagulant\/hypoprothrombinemia syndrome","volume":"4","author":"V Pengo","year":"2020","journal-title":"TH Open"},{"issue":"02","key":"ref74","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1055\/s-0038-1657668","article-title":"Successful treatment of lupus anticoagulant-hypoprothrombinemia syndrome using intravenous immunoglobulins","volume":"78","author":"G Pernod","year":"1997","journal-title":"Thromb Haemost"},{"issue":"10","key":"ref75","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1007\/s00296-018-4127-9","article-title":"Lupus anticoagulant hypoprothrombinemia syndrome associated with systemic lupus erythematosus in children: report of two cases and systematic review of the literature","volume":"38","author":"R K Pilania","year":"2018","journal-title":"Rheumatol Int"},{"issue":"01","key":"ref76","first-page":"248","article-title":"Pre-operative management of a patient with hypoprothrombinemia-lupus anticoagulant syndrome","volume":"98","author":"M B Raflores","year":"2007","journal-title":"Thromb Haemost"},{"issue":"07","key":"ref77","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/01.mph.0000174565.91343.43","article-title":"Antiphospholipid syndrome with catastrophic bleeding and recurrent ischemic strokes as initial presentation of systemic lupus erythematosus","volume":"27","author":"V Rodriguez","year":"2005","journal-title":"J Pediatr Hematol Oncol"},{"issue":"01","key":"ref78","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12959-021-00271-0","article-title":"Lupus anticoagulant hypoprothrombinemia syndrome associated with bilateral adrenal haemorrhage in a child: early diagnosis and intervention","volume":"19","author":"A Sakamoto","year":"2021","journal-title":"Thromb J"},{"issue":"06","key":"ref79","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/hae.12669","article-title":"Lupus anticoagulant acquired hypoprothrombinemia syndrome in childhood: two distinct patterns and review of the literature","volume":"21","author":"T Sarker","year":"2015","journal-title":"Haemophilia"},{"issue":"01","key":"ref80","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/PL00008415","article-title":"Gingival bleeding, epistaxis and haematoma three days after gastroenteritis: the haemorrhagic lupus anticoagulant syndrome","volume":"160","author":"M Schmugge","year":"2001","journal-title":"Eur J Pediatr"},{"issue":"03","key":"ref81","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/ki.2014.21","article-title":"The Case | A 48-year-old man with pulmonary-renal syndrome","volume":"87","author":"A Schreiber","year":"2015","journal-title":"Kidney Int"},{"issue":"03","key":"ref82","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0030-4220(84)90179-8","article-title":"Postextraction hemorrhage in a young male patient with systemic lupus erythematosus","volume":"57","author":"S Schwartz","year":"1984","journal-title":"Oral Surg Oral Med Oral Pathol"},{"issue":"03","key":"ref83","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0002-9343(87)90772-8","article-title":"Correction of hypoprothrombinemia by immunosuppressive treatment of the lupus anticoagulant-hypoprothrombinemia syndrome","volume":"83","author":"D L Simel","year":"1987","journal-title":"Am J Med"},{"issue":"09","key":"ref84","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/art.1780310926","article-title":"Severe hemorrhage in a patient with circulating anticoagulant, acquired hypoprothrombinemia, and systemic lupus erythematosus","volume":"31","author":"P Small","year":"1988","journal-title":"Arthritis Rheum"},{"issue":"04","key":"ref85","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3345\/kjp.2014.57.4.202","article-title":"Pulmonary hemorrhage in pediatric lupus anticoagulant hypoprothrombinemia syndrome","volume":"57","author":"J S Kim","year":"2014","journal-title":"Korean J Pediatr"},{"issue":"05","key":"ref86","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/MBC.0000000000000615","article-title":"Lupus anticoagulant-hypoprothrombinemia syndrome: a rare cause of intracranial bleeding","volume":"28","author":"S Sreedharanunni","year":"2017","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"01","key":"ref87","doi-asserted-by":"crossref","first-page":"77","DOI":"10.5045\/br.2023.2022200","article-title":"Lupus anticoagulant hypoprothrombinemia syndrome\u2014could it be a sequelae of COVID-19?","volume":"58","author":"N Matijasic Stjepovic","year":"2023","journal-title":"Blood Res"},{"issue":"10","key":"ref88","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1177\/09612033231191153","article-title":"Lupus anticoagulant-hypoprothrombinemia syndrome in children: three case reports and systematic review of the literature","volume":"32","author":"Y H 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