{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:52:32Z","timestamp":1792785152551,"version":"4.5.0"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"name":"NIH\/NCI Cancer Center Support Grant","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Reconstr Microsurg"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Immediate dental implant placement (IDIP) in free fibula flap (FFF) reconstruction of the mandible is an important treatment paradigm for head and neck cancer patients. This study examines the long-term safety and prosthodontic outcomes of IDIP in oncologic mandible reconstruction.<\/jats:p>\n                  <jats:p>A retrospective, noninferiority cohort study was performed comparing IDIP and non-IDIP in patients undergoing FFF reconstruction of oncologic mandibulectomy defects using computer-aided design and computer-aided manufacturing technology. Outcomes of interest included long-term complications and rates of dental rehabilitation with either an implant or nonimplant-supported resection prosthesis.<\/jats:p>\n                  <jats:p>One hundred forty-eight patients were included in the study. IDIP patients (n\u2009=\u200986) were significantly older (p\u2009=\u20090.017) and had a higher BMI (p\u2009&lt;\u20090.0001) than non-IDIP patients (n\u2009=\u200962). Median follow-up time was 2.4 and 4.9 years in the IDIP and non-IDIP groups, respectively. Complication rates were comparable between groups (p\u2009&gt;\u20090.05). The IDIP cohort received 219 dental implants, whereas four patients in the non-IDIP cohort received 10 implants in a delayed setting (p\u2009&lt;\u20090.0001). IDIP patients were more likely to achieve long-term dental rehabilitation (IDIP: 69.8%, non-IDIP: 25.8%; p\u2009&lt;\u20090.0001) and at an earlier time point (median [interquartile range]: 120 [45, 297] days vs. 355 [243, 595] days; p\u2009=\u20090.0002) after reconstruction. Adjuvant radiation did not affect the likelihood of completing dental rehabilitation in IDIP patients (p\u2009=\u20090.818).<\/jats:p>\n                  <jats:p>IDIP safely achieves dental restoration in less time and at a higher rate than non-IDIP in oncologic patients. Measurement of patient-reported outcomes is needed to bolster support for IDIP as the standard of care in oncologic patients.<\/jats:p>","DOI":"10.1055\/a-2659-6993","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T23:38:03Z","timestamp":1752881883000},"page":"324-333","source":"Crossref","is-referenced-by-count":3,"title":["Long-Term Outcomes Following Immediate Dental Implant Placement in Free Fibula Flaps for Oncologic Mandibular Reconstruction"],"prefix":"10.1055","volume":"42","author":[{"suffix":"Jr.","given":"Robert J.","family":"Allen","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5309-4221","authenticated-orcid":false,"given":"Kevin K.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zack","family":"Cohen","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annu","family":"Singh","sequence":"additional","affiliation":[{"name":"Dental Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Kronstadt","sequence":"additional","affiliation":[{"name":"Dental Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Ganly","sequence":"additional","affiliation":[{"name":"Head and Neck Oncology Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farooq","family":"Shahzad","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Rosen","sequence":"additional","affiliation":[{"name":"Rosen Prosthodontics, Peekskill, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas A.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Matros","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/cncr.31900","article-title":"Leveraging patient-reported outcomes data to inform oncology clinical decision making: introducing the FACE-Q head and neck cancer module","volume":"125","author":"J R Cracchiolo","year":"2019","journal-title":"Cancer"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1097\/PRS.0000000000002766","article-title":"Health-related quality of life following reconstruction for common head and neck surgical defects","volume":"138","author":"W A Cohen","year":"2016","journal-title":"Plast Reconstr Surg"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/PRS.0000000000007077","article-title":"Dental implant survival in vascularized bone flaps: a systematic review and meta-analysis","volume":"146","author":"H Panchal","year":"2020","journal-title":"Plast Reconstr Surg"},{"issue":"05","key":"ref4","first-page":"738","article-title":"Implant prosthodontic rehabilitation of fibula free-flap reconstructed mandibles: a Memorial Sloan-Kettering Cancer Center review of prognostic factors and implant outcomes","volume":"20","author":"K H Teoh","year":"2005","journal-title":"Int J Oral Maxillofac Implants"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"768e","DOI":"10.1097\/PRS.0000000000007352","article-title":"Short-term outcomes following virtual surgery-assisted immediate dental implant placement in free fibula flaps for oncologic mandibular reconstruction","volume":"146","author":"R J Allen Jr","year":"2020","journal-title":"Plast Reconstr Surg"},{"issue":"S 01","key":"ref6","first-page":"E321","article-title":"Osseointegrated implant-based dental rehabilitation in head and neck reconstruction patients","volume":"38","author":"S Ch'ng","year":"2016","journal-title":"Head Neck"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.coms.2018.12.005","article-title":"Maxillofacial reconstruction using vascularized fibula free flaps and endosseous implants","volume":"31","author":"S Y Patel","year":"2019","journal-title":"Oral Maxillofac Surg Clin North Am"},{"issue":"07","key":"ref8","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.jcms.2016.04.013","article-title":"Implant supported dental rehabilitation following segmental mandibular reconstruction- quality of life outcomes of a prospective randomized trial","volume":"44","author":"V V Kumar","year":"2016","journal-title":"J Craniomaxillofac 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patients","volume":"7","author":"E Schiegnitz","year":"2021","journal-title":"Int J Implant Dent"},{"issue":"02","key":"ref13","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/0022-3913(88)90015-7","article-title":"A study of factors contributing to the development of osteoradionecrosis of the jaws","volume":"59","author":"E V Kluth","year":"1988","journal-title":"J Prosthet Dent"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"119S","DOI":"10.1177\/0022034513504947","article-title":"Dental implants installed in irradiated jaws: a systematic review","volume":"92","author":"L Chambrone","year":"2013","journal-title":"J Dent Res"},{"issue":"05","key":"ref15","first-page":"289","article-title":"Computer-assisted design and computer-assisted modeling technique optimization and advantages over traditional methods of osseous flap reconstruction","volume":"30","author":"E Matros","year":"2014","journal-title":"J Reconstr 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Surg"},{"issue":"03","key":"ref30","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1055\/s-0042-1755260","article-title":"The cost utility of virtual surgical planning and computer-assisted design\/computer-assisted manufacturing in mandible reconstruction using the free fibula osteocutaneous flap","volume":"39","author":"D E Kurlander","year":"2023","journal-title":"J Reconstr Microsurg"},{"issue":"07","key":"ref31","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.joms.2011.08.024","article-title":"Free vascularized flaps for reconstruction of the mandible: complications, success, and dental rehabilitation","volume":"70","author":"J T van Gemert","year":"2012","journal-title":"J Oral Maxillofac Surg"},{"issue":"01","key":"ref32","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1600-0501.2004.01076.x","article-title":"Oral rehabilitation after mandibular reconstruction using an osteocutaneous fibula free flap with endosseous implants. Factors affecting the functional outcome in patients with oral cancer","volume":"16","author":"T Iizuka","year":"2005","journal-title":"Clin Oral Implants Res"},{"issue":"01","key":"ref33","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s40729-019-0161-y","article-title":"Outcomes of implant-based oral rehabilitation in head and neck oncology patients-a retrospective evaluation of a large, single regional service cohort","volume":"5","author":"D P Laverty","year":"2019","journal-title":"Int J Implant Dent"},{"issue":"03","key":"ref34","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00784-013-1134-9","article-title":"Oral rehabilitation with dental implants in irradiated patients: a meta-analysis on implant survival","volume":"18","author":"E Schiegnitz","year":"2014","journal-title":"Clin Oral Investig"},{"issue":"06","key":"ref35","doi-asserted-by":"crossref","first-page":"1091e","DOI":"10.1097\/PRS.0000000000007963","article-title":"Cost-effectiveness and virtual surgical planning in head and neck reconstruction: measuring what matters most","volume":"147","author":"J A Nelson","year":"2021","journal-title":"Plast Reconstr Surg"}],"container-title":["Journal of Reconstructive Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2659-6993.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:41:33Z","timestamp":1776206493000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2659-6993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,18]]},"references-count":35,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2026,4,14]]},"published-print":{"date-parts":[[2026,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2659-6993","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0743-684X","1098-8947"],"issn-type":[{"value":"0743-684X","type":"print"},{"value":"1098-8947","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7,18]]},"published":{"date-parts":[[2025,7,18]]}}}