{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:07:59Z","timestamp":1764806879845,"version":"3.46.0"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Search for laboratory markers that can predict adverse fetal pregnancy\n                        outcomes in patients with cholestasis of pregnancy.<\/jats:p>\n                  <jats:p>This was an observational case-control study conducted from December 2016 to\n                        December 2019. Pregnancy outcome data and maternal antenatal laboratory\n                        markers were collected in the intrahepatic cholestasis of pregnancy (ICP)\n                        (N=117) and normal pregnancy controls (N=100), laboratory indictors\n                        including aspartate aminotransferase (AST), alanine aminotransferase (ALT),\n                        alkaline phosphatase (ALP), \u03b3-glutamyl transpeptidase (\u03b3-GT), total\n                        bilirubin (TB), direct bilirubin (DB), total bile acids (TBA), cholyglycine\n                        (CG), prothrombin time (PT), international normalized ratio (INR), activated\n                        partial thromboplastin time (APTT), fibrinogen (FIB), etc. The ICP group was\n                        divided into an adverse outcome and normal outcome group according to fetal\n                        pregnancy outcomes. Descriptive statistics and regression analysis were\n                        performed on the prenatal indicators of the two groups to evaluate the\n                        association between prenatal laboratory indicators in ICP patients and\n                        adverse neonatal outcomes.<\/jats:p>\n                  <jats:p>ALT, TBA, CG, PT, APTT, hemoglobin, red blood cell distribution width,\n                        hematocrit, mean platelet volume, and platelet distribution width in ICP\n                        patients differed significantly from those in the normal control group,\n                        which led to premature birth, amniotic fluid pollution, low birth weight and\n                        other adverse outcomes. In terms of fetal outcomes, TBA [(39.16\u00b135.70)\n                        \u03bcmol\/L vs. (24.17\u00b118.76) \u03bcmol\/L], CG [(22.17\u00b119.42) \u03bcg\/mL vs. ( 13.91\u00b113.18)\n                        \u03bcg\/mL], DB [(22.17\u00b119.42) \u03bcg\/mL vs. (13.91\u00b113.18) \u03bcg\/mL] were higher than\n                        those in the normal outcome group, while fibrinogen was lower [(4.16\u00b11.30)\n                        g\/L vs. (4.78\u00b10.91) g\/L]; the difference was statistically significant.\n                        Multivariate logistic regression analysis showed that CG(OR=1.06,\n                        95%CI:1.01~1.12, P=0.02, FIB(OR=0.54, 95%CI:0.31~0.92, P=0.02) was\n                        independently associated with the occurrence ofadverse fetal outcomes in\n                        ICP.<\/jats:p>\n                  <jats:p>Prenatal CG and FIB levels were independently associated with adverse fetal\n                        outcomes in patients with ICP.<\/jats:p>","DOI":"10.1055\/a-2659-7707","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T23:00:02Z","timestamp":1754089202000},"page":"409-414","source":"Crossref","is-referenced-by-count":0,"title":["The value of prenatal indicators in predicting adverse fetal outcomes\n                    in patients with ICP"],"prefix":"10.1055","volume":"229","author":[{"given":"Jiahong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated\n                    Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated\n                    Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Litao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated\n                    Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9052-1007","authenticated-orcid":false,"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated\n                    Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"418","DOI":"10.12669\/pjms.322.9057","article-title":"Alanine aminotransferase as a predictor of adverse perinatal outcomes in women\n                    with intrahepatic cholestasis of pregnancy","volume":"32","author":"A Ekiz","year":"2016","journal-title":"Pak J Med Sci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1111\/1471-0528.12174","article-title":"Intrahepatic cholestasis of pregnancy and associated adverse pregnancy and fetal\n                    outcomes: a 12-year population-based cohort study","volume":"120","author":"E Wikstrom Shemer","year":"2013","journal-title":"BJOG"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1002\/hep.28265","article-title":"Prognostic and mechanistic potential of progesterone sulfates in intrahepatic\n                    cholestasis of pregnancy and pruritus gravidarum","volume":"63","author":"S Abu-Hayyeh","year":"2016","journal-title":"Hepatology"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s41586-020-2434-2","article-title":"Whole-genome sequencing of patients with rare diseases in a national health\n                    system","volume":"583","author":"E Turro","year":"2020","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1016\/j.bbadis.2017.08.033","article-title":"Drug-induced bile duct injury","volume":"1864","author":"M Visentin","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.clinre.2016.07.004","article-title":"Hepatitis C infection and intrahepatic cholestasis of pregnancy: A systematic\n                    review and meta-analysis","volume":"41","author":"K Wijarnpreecha","year":"2017","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1007\/s00404-009-1052-x","article-title":"Predicting fetal asphyxia in intrahepatic cholestasis of pregnancy","volume":"280","author":"D Oztekin","year":"2009","journal-title":"Arch Gynecol Obstet"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e0228213","DOI":"10.1371\/journal.pone.0228213","article-title":"Perinatal outcomes of intrahepatic cholestasis during pregnancy: An 8-year\n                    case-control study","volume":"15","author":"C Arthuis","year":"2020","journal-title":"PloS One"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1067\/s0002-9378(03)00545-3","article-title":"Bile acids increase response and expression of human myometrial oxytocin\n                    receptor","volume":"189","author":"A M Germain","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1542\/peds.2005-1801","article-title":"Intrahepatic cholestasis of pregnancy and neonatal respiratory distress\n                    syndrome","volume":"117","author":"E Zecca","year":"2006","journal-title":"Pediatrics"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"3614","DOI":"10.1080\/14767058.2019.1685965","article-title":"Perinatal death by bile acid levels in intrahepatic cholestasis of pregnancy: A\n                    systematic review","volume":"34","author":"D Di Mascio","year":"2021","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2979","DOI":"10.3892\/etm.2019.7312","article-title":"Effects of intrahepatic cholestasis of pregnancy on hepatic function, changes of\n                    inflammatory cytokines and fetal outcomes","volume":"17","author":"L Wang","year":"2019","journal-title":"Exp Ther Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1111\/jog.12988","article-title":"Pre-delivery fibrinogen predicts adverse maternal or neonatal outcomes in\n                    patients with placental abruption","volume":"42","author":"L Wang","year":"2016","journal-title":"J Obstet Gynaecol Res"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1097\/AOG.0b013e31818aa5b5","article-title":"Activation of the fibrinolytic cascade early in pregnancy among women with\n                    spontaneous preterm birth","volume":"112","author":"J M Catov","year":"2008","journal-title":"Obstet Gynecol"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und 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