{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:24:00Z","timestamp":1791498240329,"version":"4.3.4"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"name":"\u201cMedicine\u2009+\u2009X\u201d Interdisciplinary Research Project of Tongji University","award":["TJ-FK-YXJC020"],"award-info":[{"award-number":["TJ-FK-YXJC020"]}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Key Research and Development Program of China","award":["2024YFC3044600"],"award-info":[{"award-number":["2024YFC3044600"]}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"crossref","award":["23ZR1453200"],"award-info":[{"award-number":["23ZR1453200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanghai Eastern Talent Plan","award":["QNWS2024015"],"award-info":[{"award-number":["QNWS2024015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The clinical significance of lung cancer-associated subsegmental pulmonary embolism (PE) remains unclear.<\/jats:p>\n                  <jats:p>This study retrospectively included 902 patients with lung cancer-associated PE (160 subsegmental PE, 742 more central PE). Cox proportional hazards regression was used to assess the risk of all-cause death. Fine-Gray tests and competing risk models were applied to evaluate the risks (hazard ratio [HR] [95% confidence interval]) of venous thromboembolism (VTE) recurrence and major bleeding. All-cause death was treated as a competing event for both VTE recurrence and major bleeding.<\/jats:p>\n                  <jats:p>Compared with the more central PE group, the subsegmental PE group showed no significant differences in the adjusted risks of VTE recurrence (HR 0.99 [0.62\u20131.57], p\u2009=\u20090.95) and all-cause death (HR 0.83 [0.52\u20131.34], p\u2009=\u20090.45), and this finding was consistent across subgroups. Compared with patients with subsegmental PE without anticoagulation, those with anticoagulation had a lower adjusted risk of VTE recurrence (HR 0.16 [0.05\u20130.53], p\u2009=\u20090.003). The adjusted risks of major bleeding (HR 0.30 [0.05\u20131.70], p\u2009=\u20090.18) and all-cause death (HR 0.43 [0.13\u20131.42], p\u2009=\u20090.17) did not reach statistical significance. Independent predictors of VTE recurrence included symptomatic deep vein thrombosis (HR 2.71 [1.63\u20134.52], p\u2009&lt;\u20090.001), tumor\u2013node\u2013metastasis stage (HR 2.07 [1.19\u20133.60], p\u2009=\u20090.010), EGFR mutations (HR 0.62 [0.39\u20130.98], p\u2009=\u20090.041), and anticoagulation (HR 0.32 [0.20\u20130.52], p\u2009&lt;\u20090.001).<\/jats:p>\n                  <jats:p>The risk of recurrent VTE is not miniscule in patients with lung cancer-associated subsegmental PE.<\/jats:p>","DOI":"10.1055\/a-2661-2326","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T23:55:56Z","timestamp":1753142156000},"page":"526-536","source":"Crossref","is-referenced-by-count":3,"title":["Risk Factors and Outcomes of Subsegmental versus More Central Pulmonary Embolism in Patients with Lung Cancer"],"prefix":"10.1055","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4635-4245","authenticated-orcid":false,"given":"Delun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"He","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The First Hospital of Lanzhou University, Lanzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deping","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s10555-014-9500-x","article-title":"Clinical models and biochemical predictors of VTE in lung cancer","volume":"33","author":"M Roselli","year":"2014","journal-title":"Cancer Metastasis Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1016\/S0140-6736(16)30514-1","article-title":"Deep vein thrombosis and pulmonary embolism","volume":"388","author":"M Di Nisio","year":"2016","journal-title":"Lancet"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1378\/chest.13-2379","article-title":"Prevalence and associations of VTE in patients with newly diagnosed lung cancer","volume":"146","author":"Y Zhang","year":"2014","journal-title":"Chest"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/jth.12803","article-title":"Sub-segmental pulmonary embolism in three academic teaching hospitals: a review of management and outcomes","volume":"13","author":"J Goy","year":"2015","journal-title":"J Thromb Haemost"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/rth2.12446","article-title":"Symptomatic subsegmental versus more central pulmonary embolism: clinical outcomes during anticoagulation","volume":"5","author":"C Fern\u00e1ndez-Capit\u00e1n","year":"2020","journal-title":"Res Pract Thromb Haemost"},{"issue":"11","key":"ref6","first-page":"986","article-title":"Isolated subsegmental pulmonary embolism: current therapeutic challenges","volume":"130","author":"H HB Yoo","year":"2020","journal-title":"Pol Arch Intern Med"},{"issue":"08","key":"ref7","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1111\/j.1538-7836.2010.03938.x","article-title":"Subsegmental pulmonary embolism diagnosed by computed tomography: incidence and clinical implications. A systematic review and meta-analysis of the management outcome studies","volume":"8","author":"M Carrier","year":"2010","journal-title":"J Thromb Haemost"},{"issue":"08","key":"ref8","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1111\/j.1538-7836.2012.04804.x","article-title":"Symptomatic subsegmental pulmonary embolism: what is the next step?","volume":"10","author":"M Carrier","year":"2012","journal-title":"J Thromb Haemost"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s11239-015-1169-7","article-title":"Clinical significance and management of subsegmental pulmonary embolism","volume":"39","author":"R Ikesaka","year":"2015","journal-title":"J Thromb Thrombolysis"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"e545","DOI":"10.1016\/j.chest.2021.07.055","article-title":"Antithrombotic therapy for VTE disease: second update of the CHEST guideline and expert panel report","volume":"160","author":"S M 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