{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:52:03Z","timestamp":1781535123767,"version":"3.54.5"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to evaluate the outcomes of pregnancies immediately following stillbirth in relation to treatments prescribed.<\/jats:p>\n                  <jats:p>A prospective, observational study was conducted in patients with a history of stillbirth (\u226522 weeks) between 2014 and 2022 across four Italian University Hospitals. Outcomes were stratified based on the cause of previous fetal death (classified according to ReCoDe classification) and treatment (low dose aspirin [LDA], low molecular weight heparin [LMWH], both, progesterone, or other drugs). The main outcome was adverse neonatal outcome, including perinatal death, stillbirth recurrence, intrauterine growth restriction, early preterm birth, Apgar\u2009&lt;\u20097 at 5\u2009minutes, and need for neonatal resuscitation. The secondary outcome was adverse maternal outcome, including postpartum hemorrhage, emergency cesarean delivery, and operative vaginal delivery.<\/jats:p>\n                  <jats:p>Among 308 subsequent pregnancies, 46 (14.94%) had an adverse neonatal outcome, including 4 stillbirths. A total of 76 pregnancies (24.68%) experienced adverse maternal outcome, and 19 pregnancies (6.17%) had both. In individuals with previous placental vascular disorders (PVDs), adverse neonatal outcomes were reduced by 75% when treated with LDA\u2009+\u2009LMWH (odds ratio [OR]: 0.25; 95% confidence interval [CI]: 0.06\u20131.03; p\u2009=\u20090.049). However, adverse maternal outcome was significantly higher in individuals who received LDA\u2009+\u2009LMWH without specific indications (OR: 3.07; 95% CI: 1.07\u20138.78; p\u2009=\u20090.036).<\/jats:p>\n                  <jats:p>LDA and LMWH should be prescribed only for previous PVDs to improve adverse neonatal outcome and avoid unnecessary maternal risk.<\/jats:p>","DOI":"10.1055\/a-2661-4287","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:31:07Z","timestamp":1753230667000},"page":"587-594","source":"Crossref","is-referenced-by-count":0,"title":["Perinatal Outcomes in Pregnancies Immediately following Stillbirth: A Multicenter, Prospective, Observational Study"],"prefix":"10.1055","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0568-9892","authenticated-orcid":false,"given":"Martina","family":"Benuzzi","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Unit, Mother-Infant and Adult Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Cuoghi Costantini","sequence":"additional","affiliation":[{"name":"Mother-Infant and Adult Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Sadd\u00f2","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Unit, Mother-Infant and Adult Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Selleri","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Unit, Mother-Infant and Adult Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Verra","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Unit, Mother-Infant and Adult Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Melis","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Unit, Mother-Infant and Adult Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Guariglia","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Unit, Mother-Infant and Adult Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Avagliano","sequence":"additional","affiliation":[{"name":"University of Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Serena","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Unit, Department of Experimental, Clinical and Biomedical Sciences, Careggi University Hospital, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Mecacci","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Unit, Department of Experimental, Clinical and Biomedical Sciences, Careggi University Hospital, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Baggio","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Unit, Department of Experimental, Clinical and Biomedical Sciences, Careggi University Hospital, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Gabbrielli","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Unit, Department of Experimental, Clinical and Biomedical Sciences, Careggi University Hospital, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Fieni","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane J. O.","family":"Kiener","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Pavan","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinunzia","family":"Salluce","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Cozzolino","sequence":"additional","affiliation":[{"name":"Obstetrics Unit, IRCCS San Gerardo dei Tintori, Monza, Monza and Brianza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Obstetrics Unit, IRCCS San Gerardo dei Tintori, Monza, Monza and Brianza, Italy"},{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Alongi","sequence":"additional","affiliation":[{"name":"Obstetrics Unit, IRCCS San Gerardo dei Tintori, Monza, Monza and Brianza, Italy"},{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Camponovo","sequence":"additional","affiliation":[{"name":"Obstetrics Unit, IRCCS San Gerardo dei Tintori, Monza, Monza and Brianza, Italy"},{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Lazzarin","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Unit, Mother-Infant and Adult Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Neri","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Unit, Mother-Infant and Adult Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Facchinetti","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Unit, Mother-Infant and Adult Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"La 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