{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:03:44Z","timestamp":1790240624755,"version":"4.1.0"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"name":"Fujifilm Europe","award":["CER21.305"],"award-info":[{"award-number":["CER21.305"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Computer-aided diagnosis (CADx) of colorectal polyps during colonoscopy could replace pathology for certain polyps. This study aimed to evaluate CADx-assisted optical diagnosis for polyps of \u226410 mm in the context of established quality benchmarks.<\/jats:p>\n                  <jats:p>We performed a post-hoc analysis of a randomized controlled trial evaluating assistive versus autonomous computer-aided optical diagnosis. Our primary outcome was achievement of the American Society for Gastrointestinal Endoscopy PIVI1 threshold for resect-and-discard implementation when CADx was used for polyps \u22643 mm. Secondary outcomes included PIVI1 threshold achievement when using CADx with a size cutoff of \u22645 mm and \u226410 mm, as well as diagnostic performance and prevalence of advanced histology across the polyp size groups.<\/jats:p>\n                  <jats:p>We included 313 patients with a total of 463 polyps of \u226410 mm undergoing optical diagnosis with CADx assistance. Compared with pathology-based intervals, surveillance interval agreement was 94.6% (95%CI 91.3%\u201396.7%), 89.5% (95%CI 85.4%\u201392.5%), and 85.9% (95%CI 81.5%\u201389.5%) when CADx was used with size cutoffs \u22643 mm, \u22645 mm, and \u226410 mm, respectively. The diagnostic accuracy of CADx-assisted optical diagnosis was 76.2%, 76.6%, and 72.5% for polyps sized \u22643 mm, &gt;3 to \u22645 mm, and &gt;5 to \u226410 mm, respectively. The negative predictive value for rectosigmoid adenomas was &gt;90% for all size groups (PIVI2). The prevalence of advanced or serrated pathology was higher in polyps &gt;3 mm, which resulted in a higher number of incorrectly assigned surveillances intervals.<\/jats:p>\n                  <jats:p>In our study, CADx-assisted optical diagnosis met the resect-and-discard PIVI1 threshold only with a size cutoff of \u22643 mm, and the diagnose-and-leave PIVI2 threshold for polyps \u226410 mm.<\/jats:p>","DOI":"10.1055\/a-2663-7661","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:26:43Z","timestamp":1753316803000},"page":"132-140","source":"Crossref","is-referenced-by-count":7,"title":["Computer-assisted optical diagnosis of colorectal polyps up to 10 mm"],"prefix":"10.1055","volume":"58","author":[{"given":"Megan","family":"Oleksiw","sequence":"first","affiliation":[{"name":"Gastroenterology, Montreal University Hospital Research Center, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Taghiakbari","sequence":"first","affiliation":[{"name":"Gastroenterology, Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), Montreal, Canada"},{"name":"Gastroenterology, Montreal University Hospital Research Center, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0649-0691","authenticated-orcid":false,"given":"Roupen","family":"Djinbachian","sequence":"additional","affiliation":[{"name":"Gastroenterology, Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), Montreal, Canada"},{"name":"Gastroenterology, Montreal University Hospital Research Center, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Pohl","sequence":"additional","affiliation":[{"name":"Gastroenterology, Dartmouth Hitchcock Medical Center, Lebanon, United States"},{"name":"Gastroenterology, VA Medical Center, White River Junction, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Barkun","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, McGill University Health Centre, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas K.","family":"Rex","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Panzini","sequence":"additional","affiliation":[{"name":"Gastroenterology, Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Bouchard","sequence":"additional","affiliation":[{"name":"Gastroenterology, Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Lasfar","sequence":"additional","affiliation":[{"name":"Gastroenterology, Montreal University Hospital Research Center, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Amani","sequence":"additional","affiliation":[{"name":"Gastroenterology, Montreal University Hospital Research Center, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Dubois","sequence":"additional","affiliation":[{"name":"Gastroenterology, Montreal University Hospital Research Center, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousr","family":"Jalal","sequence":"additional","affiliation":[{"name":"Gastroenterology, Montreal University Hospital Research Center, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Bouin","sequence":"additional","affiliation":[{"name":"Gastroenterology, Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), Montreal, Canada"},{"name":"Gastroenterology, Montreal University Hospital Research Center, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6125-0068","authenticated-orcid":false,"given":"Daniel","family":"von Renteln","sequence":"additional","affiliation":[{"name":"Gastroenterology, Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), Montreal, Canada"},{"name":"Gastroenterology, Montreal University Hospital Research Center, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1136\/gutjnl-2014-307742","article-title":"Real-time optical diagnosis for diminutive colorectal polyps using narrow-band imaging: the VALID randomised clinical trial","volume":"64","author":"T Kaltenbach","year":"2015","journal-title":"Gut"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1136\/gutjnl-2012-303965","article-title":"Narrow band imaging to differentiate neoplastic and non-neoplastic colorectal polyps in real time: a meta-analysis of diagnostic operating characteristics","volume":"62","author":"SK McGill","year":"2013","journal-title":"Gut"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"502.e1","DOI":"10.1016\/j.gie.2014.12.022","article-title":"ASGE Technology Committee systematic review and meta-analysis assessing the ASGE 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Zhang","year":"2024","journal-title":"iScience"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1053\/j.gastro.2019.10.024","article-title":"Use of endoscopic impression, artificial intelligence, and pathologist interpretation to resolve discrepancies between endoscopy and pathology analyses of diminutive colorectal polyps","volume":"158","author":"N Shahidi","year":"2020","journal-title":"Gastroenterology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1055\/a-0831-2348","article-title":"Disagreement between high confidence endoscopic adenoma prediction and histopathological diagnosis in colonic lesions \u22643 mm in size","volume":"51","author":"P Ponugoti","year":"2019","journal-title":"Endoscopy"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.14309\/ajg.0000000000002623","article-title":"Measuring size of colorectal polyps using a virtual scale endoscope or visual assessment: a randomized controlled 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Vleugels","year":"2019","journal-title":"Gastroenterology"}],"container-title":["Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2663-7661.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:33:04Z","timestamp":1769124784000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2663-7661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,23]]},"references-count":33,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2026,1,22]]},"published-print":{"date-parts":[[2026,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2663-7661","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0013-726X","1438-8812"],"issn-type":[{"value":"0013-726X","type":"print"},{"value":"1438-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7,23]]},"published":{"date-parts":[[2025,7,23]]}}}