{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:03:27Z","timestamp":1783652607398,"version":"3.55.0"},"reference-count":156,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["1RO1 HL157441"],"award-info":[{"award-number":["1RO1 HL157441"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Thromboinflammation is an emerging concept which highlights the interactions between coagulation and inflammation in various disease states. Activation of coagulation and inflammation are both hallmarks of hemolytic states. However, the mechanisms by which they cause adverse outcomes in hemolytic disorders is incompletely understood. A body of literature suggests that red blood cells (RBCs) play a role in thrombosis and in immune regulation. RBCs release extracellular vesicles (RBC-EVs), with increased numbers found in the circulation of patients with hemolytic disorders. In this review, we summarize the existing literature addressing the interaction of RBC-EVs with coagulation and inflammatory pathways in vitro and in vivo. Additionally, we discuss the potential contribution of RBC-EV-induced thromboinflammation in the pathogenesis of certain complications of sickle cell disease as a model of a severe hemolytic disorder.<\/jats:p>","DOI":"10.1055\/a-2664-0871","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T23:45:49Z","timestamp":1753400749000},"page":"537-549","source":"Crossref","is-referenced-by-count":1,"title":["Red Blood Cell Extracellular Vesicles as Key Players in Thromboinflammation"],"prefix":"10.1055","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1298-345X","authenticated-orcid":false,"given":"Denis F.","family":"Noubouossie","sequence":"additional","affiliation":[{"name":"Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel S.","family":"Key","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of North Carolina, Chapel Hill, North Carolina"},{"name":"UNC Blood Research Center, University of North Carolina, Chapel Hill, North Carolina"},{"name":"Division of Hematology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"issue":"16","key":"ref1","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1182\/blood-2017-03-745349","article-title":"Red blood cells in thrombosis","volume":"130","author":"J R Byrnes","year":"2017","journal-title":"Blood"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/MOH.0000000000000734","article-title":"Immunomodulatory roles of red blood cells","volume":"29","author":"J Dobkin","year":"2022","journal-title":"Curr Opin Hematol"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/jth.14360","article-title":"Red 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