{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:54:02Z","timestamp":1791978842992,"version":"4.4.0"},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gastrointestinal (GI) defects with inflamed, fibrotic edges are often refractory to traditional endoscopic treatments. This study evaluates the efficacy and safety of endoscopically delivered stromal vascular fraction from autologous adipose tissue (tSVFem), which promotes tissue regeneration in upper and lower GI defects without additional patient risk or cost.<\/jats:p>\n                  <jats:p>This pilot trial involved patients with GI defects accessible by endoscopy after traditional treatments had failed. The tSVFem was derived from harvested hip fat, which was processed and injected endoscopically into the defect margins. The primary outcome was complete defect resolution. Secondary outcomes included treatment frequency, procedure-related adverse events, and recurrence.<\/jats:p>\n                  <jats:p>30 patients were included: 15 with esophageal defects (median diameter 6 mm) and 15 with rectal defects (median diameter 5 mm). Of the 15 esophageal defects, 14 showed complete resolution after tSVFem injection (10 after one injection and 4 after two injections). The overall resolution rate for rectal defects was 60% (six after one treatment, one after two treatments, and two after three or four treatments). The resolution rate was 5\/9 for rectal defects communicating with the urinary tract and 4\/6 for those communicating with other organs. No intraprocedural or postprocedural adverse events or defect recurrence occurred.<\/jats:p>\n                  <jats:p>These results suggest that endoscopic injection of autologous tSVFem may treat complex esophageal and rectal defects, including those communicating with adjacent organs other than the urinary tract.<\/jats:p>","DOI":"10.1055\/a-2665-1777","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T23:36:29Z","timestamp":1753400189000},"page":"193-199","source":"Crossref","is-referenced-by-count":4,"title":["Regenerative endoscopy for the treatment of difficult gastrointestinal defects: results from a pilot trial"],"prefix":"10.1055","volume":"58","clinical-trial-number":[{"clinical-trial-number":"nct04670276","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Dania","family":"Nachira","sequence":"first","affiliation":[{"name":"Department of General Thoracic Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Pontecorvi","sequence":"first","affiliation":[{"name":"Digestive Endoscopy Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Trivisonno","sequence":"additional","affiliation":[{"name":"Unit of Plastic Surgery, Assunzione di Maria Santissima Clinic, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Papi","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienze, Universit\u00e0 Cattolica del Sacro Cuore, Roma, Italy"},{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Toietta","sequence":"additional","affiliation":[{"name":"Department of Research, Advanced Diagnostic, and Technological Innovation, Translational Research Area, IRCCS Regina Elena National Cancer Institute, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Fanfani","sequence":"additional","affiliation":[{"name":"Dipartimento per la Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"},{"name":"Dipartimento di Scienze della Vita e Sanit\u00e0 Pubblica, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Scambia","sequence":"additional","affiliation":[{"name":"Dipartimento per la Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica, Fondazione Policlinico Universitario Agostino 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