{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:49:41Z","timestamp":1787168981853,"version":"build-2736575974"},"reference-count":52,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Facial Plast Surg"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The infraorbital region is challenging to treat due to complex anatomy and issues like skin laxity, malar edema, and malar mounds. This study evaluates micro focused ultrasound with visualization (MFU-V) as a non-invasive treatment for infraorbital rejuvenation, hypothesizing improved skin tightening and contouring.<\/jats:p>\n                  <jats:p>A case series with anatomical analysis and literature review.<\/jats:p>\n                  <jats:p>Five female patients (aged 42\u201354) with mild-to-moderate skin laxity underwent MFU-V treatment using 1.5, 3.0, and 4.5\u2009mm transducers. Standardized photos and assessment scales (Merz Infraorbital Hollow Scale, GAIS) were used at baseline and 6 months.<\/jats:p>\n                  <jats:p>MFU-V led to visible improvements in periorbital skin tightening and reduction of malar mounds, especially in more pronounced cases. No adverse effects occurred.<\/jats:p>\n                  <jats:p>MFU-V is a safe, effective, and non-invasive option for periorbital rejuvenation. It may serve as an alternative to surgical treatment for infraorbital skin laxity and malar deformities. Larger studies are needed to confirm efficacy.<\/jats:p>","DOI":"10.1055\/a-2666-5719","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T22:56:16Z","timestamp":1754434576000},"page":"367-376","source":"Crossref","is-referenced-by-count":2,"title":["First Clinical Experiences with Microfocused Ultrasound in Infraorbital Rejuvenation: A Clinically and Scientifically Grounded Perspective"],"prefix":"10.1055","volume":"42","author":[{"given":"Wolfram","family":"Heitzmann","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, Hand Surgery, Burn Center, Cologne-Merheim Medical Center (CMMC), University of Witten, Herdecke, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Lynn","family":"Schiefer","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, Hand Surgery, Burn Center, Cologne-Merheim Medical Center (CMMC), University of Witten, Herdecke, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Lanckohr","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hand Surgery, Burn Center, Cologne-Merheim Medical Center (CMMC), University of Witten, Herdecke, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Visnovska","sequence":"additional","affiliation":[{"name":"Department of Dermatology \u2013 Section of Aesthetic Dermatology \u2013 Division of Outpatient Services, Concept Clinic, Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Schulz","sequence":"additional","affiliation":[{"name":"University of Witten, Herdecke, Germany"},{"name":"We Are Beautiful, Alexandra Schulz - Privatpraxis f\u00fcr Plastische Chirurgie, Kempten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/1090820X13517897","article-title":"Malar mounds and festoons: Review of current management","volume":"34","author":"D S Kpodzo","year":"2014","journal-title":"Aesthet Surg J"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.jaad.2023.12.047","article-title":"A comparison of 1550-nm fractional photothermolysis versus intense focused ultrasound for treatment of periorbital wrinkles: A randomized control trial","volume":"90","author":"E Koza","year":"2024","journal-title":"J Am Acad Dermatol"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"214","DOI":"10.5999\/aps.2017.01193","article-title":"Definitions of groove and hollowness of the infraorbital region and clinical treatment using soft-tissue filler","volume":"45","author":"J-H Lee","year":"2018","journal-title":"Arch Plast Surg"},{"issue":"08","key":"ref4","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1111\/j.1524-4725.2009.01213.x","article-title":"Infraorbital dark circles: Definition, causes, and treatment options","volume":"35","author":"M R Roh","year":"2009","journal-title":"Dermatol Surg"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.anplas.2017.09.007","article-title":"Anatomy of lower eyelid and eyelid-cheek junction","volume":"62","author":"A Mojallal","year":"2017","journal-title":"Ann Chir Plast Esthet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.2147\/CCID.S311017","article-title":"Consensus on the use of hyaluronic acid fillers from the cohesive polydensified matrix range: Best practice in specific facial indications","volume":"14","author":"J van Loghem","year":"2021","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2147\/CCID.S106551","article-title":"Hyaluronic acid fillers with cohesive polydensified matrix for soft-tissue augmentation and rejuvenation: A literature review","volume":"9","author":"A D Prasetyo","year":"2016","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"540e","DOI":"10.1097\/PRS.0000000000003716","article-title":"Facial assessment and injection guide for botulinum toxin and injectable hyaluronic acid fillers: Focus on the midface","volume":"140","author":"M de Maio","year":"2017","journal-title":"Plast Reconstr Surg"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.25056\/JCM.2017.1.1.1","article-title":"The troublesome triad: Festoons, malar mounds, and palpebral bags","volume":"1","author":"L KW Phoebe","year":"2017","journal-title":"Journal of Cosmetic Medicine."},{"issue":"05","key":"ref10","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1097\/01.PRS.0000157016.49072.61","article-title":"What causes eyelid bags? 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