{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:04:24Z","timestamp":1783127064472,"version":"3.54.6"},"reference-count":72,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Venous thromboembolism is often underestimated in transfusion-dependent thalassemia (TDT) patients, as arterial thrombotic events are more commonly observed. Although therapeutic advancements have transformed this disease from a once-fatal childhood disease into a manageable chronic condition, some treatments may contribute to an increased risk of thrombosis. Additionally, the prolonged life expectancy of these patients further contributes to the overall thrombotic risk. Patients with thalassemia major present multiple challenges when considering anticoagulation therapy. The decision-making process is complicated by a delicate balance between thrombotic risk\u2014driven by disease-related and treatment-associated factors\u2014and potential bleeding tendencies, particularly in the presence of comorbid conditions such as liver dysfunction, hypersplenism, or thrombocytopenia. Therefore, ongoing assessment of both thrombotic and bleeding risk and the implementation of appropriate preventive strategies are essential to optimize patient outcomes. This document presents a consensus statement from the Steering Committee of the Hemostasis Working Group of the Hellenic Society of Hematology, offering guidance on thromboprophylaxis and anticoagulation management in adult TDT patients.<\/jats:p>","DOI":"10.1055\/a-2669-7739","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T23:48:21Z","timestamp":1753832901000},"page":"174-185","source":"Crossref","is-referenced-by-count":1,"title":["Transfusion-Dependent Thalassemia and Venous Thromboembolism Management: Position Statement from the Steering Committees of Hemostasis and Erythrocyte and Hemoglobinopathies Study Groups\u2014Hellenic Society of Haematology"],"prefix":"10.1055","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6967-9785","authenticated-orcid":false,"given":"Vasiliki","family":"Danilatou","sequence":"additional","affiliation":[{"name":"School of Medicine, European University Cyprus, Nicosia, Cyprus"},{"name":"Research 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Sickle Cell Unit, Expertise Center of Hemoglobinopathies and Their Complications, Hippokrateio General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotios","family":"Girtovitis","sequence":"additional","affiliation":[{"name":"Blood Center, AHEPA University General Hospital of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"ref1","volume-title":"Management of Transfusion Dependent Thalassemia (TDT)","author":"D Farmakis","year":"2022","edition":"2nd ed."},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1182\/asheducation-2007.1.74","article-title":"Coagulation in the pathophysiology of hemolytic anemias","volume":"2007","author":"M D Cappellini","year":"2007","journal-title":"Hematology (Am Soc Hematol Educ 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