{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T23:07:12Z","timestamp":1779318432239,"version":"3.51.4"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Crimean-Congo hemorrhagic fever (CCHF) is one of the most common viral\n                        hemorrhagic fevers. After entering the body, the virus replicates in\n                        regional lymph nodes and tissues, then spreads via lymph and monocytes,\n                        causing systemic inflammatory response syndrome, septic shock, and\n                        disseminated intravascular coagulation (DIC).<\/jats:p>\n                  <jats:p>Sociodemographic, clinical, and hematological data of children (0\u201318 years)\n                        diagnosed with CCHF at the Pediatric Infectious Diseases Clinic of Erzurum\n                        Training and Research Hospital between September 2018 and June 2020 were\n                        analyzed.<\/jats:p>\n                  <jats:p>Of 19 patients, 14 were male and 5 female, with a mean age of 14.2\u00b13.2 years.\n                        Common presenting symptoms included fever, fatigue, and myalgia. Initial lab\n                        results showed a white blood cell count of 3012\u00b11559\/mm\u00b3, platelet count of\n                        102.105 \u00b1 50.350\/mm\u00b3, and PT of 17.3\u00b13.5\u2009seconds. Two patients with\n                        persistent fever (&gt;5 days) developed CCHF-associated hemophagocytic\n                        syndrome and received intravenous immunoglobulin in addition to ribavirin.\n                        Eleven patients with severe thrombocytopenia and\/or bleeding received\n                        apheresis platelet concentrates; six received fresh frozen plasma.<\/jats:p>\n                  <jats:p>CCHF should be considered in patients\u2014regardless of tick exposure\u2014presenting\n                        with sudden fever, fatigue, leukopenia, thrombocytopenia, abnormal\n                        coagulation, and elevated liver enzymes.<\/jats:p>","DOI":"10.1055\/a-2669-8035","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:45:38Z","timestamp":1757976338000},"page":"164-168","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Clinical and Hematological Findings of Pediatric\n                    Patients with Crimean-Congo Hemorrhagic Fever"],"prefix":"10.1055","volume":"238","author":[{"given":"Emine Hafize","family":"Erdeniz","sequence":"additional","affiliation":[{"name":"Ondokuz Mayis University Faculty of Medicine, Division of Pediatric\n                    Infectious Diseases, Department of Pediatrics,Ondokuz Mayis University, Samsun,\n                    TURKEY"},{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics,\n                    Erzurum Training and Research Hospital, Erzurum, TURKEY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeter D\u00fczenli","family":"Kar","sequence":"additional","affiliation":[{"name":"Bursa Uluda\u011f University Faculty of Medicine, Division of Pediatric\n                    Hematology, Department of Pediatrics, Bursa Uluda\u011f University, Bursa,\n                    TURKEY"},{"name":"Division of Pediatric Hematology and Oncology, Department of\n                    Pediatrics, Erzurum Training and Research Hospital, Erzurum,\n                    TURKEY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.antiviral.2013.07.006","article-title":"Crimean-Congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical\n                    syndrome and genetic diversity","volume":"100","author":"D A Bente","year":"2013","journal-title":"Antiviral Res"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/s41579-023-00871-9","article-title":"Crimean-Congo haemorrhagic fever virus","volume":"21","author":"D W Hawman","year":"2023","journal-title":"Nat Rev Microbiol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.virs.2023.01.001","article-title":"Crimean-Congo hemorrhagic fever virus in Central, Eastern, and South-eastern\n                    Asia","volume":"38","author":"M Fereidouni","year":"2023","journal-title":"Virol Sin"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"106054","DOI":"10.1016\/j.micpath.2023.106054","article-title":"Crimean-Congo hemorrhagic fever: Immunopathogenesis and recent advances in the\n                    development of vaccines","volume":"177","author":"F Munir","year":"2023","journal-title":"Microb Pathog"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.medmal.2019.09.005","article-title":"Crimean-Congo hemorrhagic fever: An update","volume":"49","author":"P Fillatre","year":"2019","journal-title":"Med Mal Infect"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e43315","DOI":"10.7759\/cureus.43315","article-title":"Crimean-Congo Hemorrhagic Fever: An Emerging Viral Infection in India, Revisited\n                    and Lessons Learned","volume":"15","author":"A A Patel","year":"2023","journal-title":"Cureus"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"553","DOI":"10.5578\/mb.20239945","article-title":"[A New Score for Predicting Mortality in Crimean-Congo Hemorrhagic Fever\n                    Associating CURB-65 with Bleeding: CURB-65+B]","volume":"57","author":"R Inan Sarikaya","year":"2023","journal-title":"Mikrobiyol Bul"},{"key":"ref10","first-page":"209","article-title":"Erzurum ilinde K\u0131r\u0131m Kongo kanamal\u0131 ate\u015f sendromuyla izlenen \u00e7ocuk hastalar\u0131n\n                    geriye d\u00f6n\u00fck olarak de\u011ferlendirmesi","volume":"11","author":"S S Kara","year":"2018","journal-title":"Pamukkale Medical Journal"},{"key":"ref11","first-page":"13","article-title":"K\u0131r\u0131m-Kongo Kanamal\u0131 Ate\u015fi Nedeniyle \u00c7ocuk Yo\u011fun Bak\u0131m \u00dcnitesine Yat\u0131r\u0131lan\n                    Hastalarda Trombosit Aktivite Belirte\u00e7lerinin Etkisi: K\u0131r\u0131m-Kongo Kanamal\u0131 Ate\u015fi\n                    ve Trombosit Aktivite Belirte\u00e7leri","volume":"2","author":"R Yilmaz","year":"2021","journal-title":"Chronicles of Precision Medical Researchers"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"268","DOI":"10.3201\/eid2902.220976","article-title":"Changing Disease Course of Crimean-Congo Hemorrhagic Fever in Children,\n                    Turkey","volume":"29","author":"P D Oygar","year":"2023","journal-title":"Emerg Infect Dis"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"101","DOI":"10.47665\/tb.40.1.016","article-title":"Immature platelet fraction as a useful marker in Crimean-Congo hemorrhagic\n                    fever","volume":"40","author":"Z C Ozmen","year":"2023","journal-title":"Trop Biomed"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.jcv.2010.04.001","article-title":"Crimean-Congo hemorrhagic fever in children","volume":"48","author":"H Tezer","year":"2010","journal-title":"J Clin Virol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"e194","DOI":"10.1097\/INF.0000000000000281","article-title":"Evaluation of children with Crimean-Congo hemorrhagic fever in the central\n                    Blacksea region","volume":"33","author":"N Belet","year":"2014","journal-title":"Pediatr Infect Dis J"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.tmaid.2016.03.012","article-title":"Current situation of Crimean-Congo hemorrhagic fever in Southeastern Europe and\n                    neighboring countries: a public health risk for the European Union?","volume":"14","author":"S Dreshaj","year":"2016","journal-title":"Travel Med Infect Dis"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"252","DOI":"10.3201\/eid2902.220677","article-title":"Crimean-Congo Hemorrhagic Fever, Spain, 2013-2021","volume":"29","author":"H M Lorenzo Juanes","year":"2023","journal-title":"Emerg Infect Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4103\/0972-9062.213375","article-title":"A new perspective to determine the severity of cases with Crimean-Congo\n                    hemorrhagic fever","volume":"49","author":"M Bakir","year":"2012","journal-title":"J Vector Borne Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1089\/vbz.2024.0066","article-title":"A comparison of clinical and laboratory features of Crimean-Congo hemorrhagic\n                    fever in children and adults: a retrospective single-center cohort study and\n                    literature review","volume":"25","author":"I Bozkurt","year":"2025","journal-title":"Vector-Borne and Zoonotic Diseases"}],"container-title":["Klinische 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