{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T14:29:54Z","timestamp":1783434594516,"version":"3.54.6"},"reference-count":174,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":34,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Respir Crit Care Med"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Poor repair following lung injury is a significant cause of morbidity and mortality. Clearance of apoptotic cells, termed efferocytosis, has emerged as a key process that can influence repair outcomes and facilitate successful repair. Although prior literature has focused on efferocytosis by macrophages, evidence is emerging that nonprofessional phagocytes, including fibroblasts and epithelial cells, may play critical roles in efferocytosis during tissue repair. This review summarizes existing knowledge of different lung phagocytes that can participate in efferocytosis, evidence linking efferocytosis to lung health and tissue repair, and discusses factors that may inhibit or redirect efferocytosis to promote mis-repair. A deeper understanding of how the integrated landscape of lung phagocytes participates in efferocytosis will likely provide significant insight into repair and mis-repair processes.<\/jats:p>","DOI":"10.1055\/a-2675-2564","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T22:52:25Z","timestamp":1757026345000},"page":"311-321","source":"Crossref","is-referenced-by-count":3,"title":["Heterogeneity of Lung Phagocytes and Clearance of Apoptotic Cells in Lung Injury and Repair"],"prefix":"10.1055","volume":"46","author":[{"given":"Stephanie M.","family":"Bersie","sequence":"additional","affiliation":[{"name":"Toxicology Graduate Program, University of Colorado Denver Skaggs School of Pharmacy, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra L.","family":"McCubbrey","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Jewish Health, Denver, Colorado"},{"name":"Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/0140-6736(91)91443-X","article-title":"Neutrophil apoptosis and clearance from neonatal lungs","volume":"338","author":"J M Grigg","year":"1991","journal-title":"Lancet"},{"issue":"03","key":"ref2","first-page":"845","article-title":"Apoptosis is a major pathway responsible for the resolution of type II pneumocytes in acute lung injury","volume":"149","author":"R H Bardales","year":"1996","journal-title":"Am J Pathol"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/S0002-9440(10)64455-0","article-title":"Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress 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