{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T19:14:51Z","timestamp":1780773291027,"version":"3.54.1"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die Osteomyelitis des Felsenbeins (OF) ist eine seltene entz\u00fcndliche Erkrankung, die sich vom Geh\u00f6rgang auf angrenzende Weichteil- und Knochenstrukturen ausbreiten kann. Diese entz\u00fcndliche Affektion von Nachbarstrukturen stellt eine therapeutische Herausforderung dar und kann lebensbedrohlich verlaufen. Der Nachweis des zugrunde liegenden Erregers ist entscheidend f\u00fcr eine erfolgreiche Therapie. Aktuelle Studien haben ein breites Erregerspektrum bei der OF gezeigt. Unser Studienziel waren die Analyse des mikrobiologischen Spektrums in unserem Patientenkollektiv mit OF und ein Vergleich dieser Daten mit der aktuellen Literatur.<\/jats:p>\n                  <jats:p>In dieser retrospektiven, monozentrischen Studie wurden Patienten eingeschlossen, bei denen in einem 10-Jahres-Zeitraum eine OF diagnostiziert wurde (n=39). Wir analysierten das mikrobiologische Spektrum, die klinischen Symptome, die radiologischen Befunde und den Krankheitsverlauf.<\/jats:p>\n                  <jats:p>Die h\u00e4ufigsten Symptome waren Otalgie (n=29, 74,4%) und Otorrhoe (n=24, 61,5%). In mikrobiologischen Untersuchungen wurde am h\u00e4ufigsten P. aeruginosa (n=21, 53,8%) nachgewiesen. Der Nachweis dieses Erregers korrelierte mit erh\u00f6hten CRP-Werten (p&lt;0,05). In computertomografischen Untersuchungen lie\u00df sich bei 38 Patienten (97,4%) eine ausgewaschene Knochentextur des Felsenbeins nachweisen. W\u00e4hrend des Nachbeobachtungszeitraums berichteten 10 Patienten (25,6%) \u00fcber eine Verringerung, 23 Patienten (59,0%) hingegen \u00fcber eine Persistenz der Symptome. Vier Patienten (10,3%) verstarben.<\/jats:p>\n                  <jats:p>Im Gegensatz zu k\u00fcrzlich ver\u00f6ffentlichten Daten ist in unserer Patientenkohorte P. aeruginosa nach wie vor der h\u00e4ufigste und herausforderndste Erreger der OF. Daher sollte bei der Auswahl einer empirischen Therapie stets auf deren Wirksamkeit gegen diesen Erreger geachtet werden.<\/jats:p>","DOI":"10.1055\/a-2681-5314","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T23:34:40Z","timestamp":1758065680000},"page":"231-238","source":"Crossref","is-referenced-by-count":1,"title":["Pseudomonas aeruginosa bleibt der vorherrschende Erreger bei Osteomyelitis des Felsenbeins"],"prefix":"10.1055","volume":"105","author":[{"given":"Leon","family":"Guchlerner","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Kopf- und Hals- Chirurgie, Universit\u00e4tsmedizin Frankfurt, Goethe-Universit\u00e4t Frankfurt am Main, Frankfurt, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hogardt","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Mikrobiologie und Krankenhaushygiene, Universit\u00e4tsmedizin Frankfurt, Goethe-Universit\u00e4t Frankfurt am Main, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Ilievski","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Mikrobiologie und Krankenhaushygiene, Universit\u00e4tsmedizin Frankfurt, Goethe-Universit\u00e4t Frankfurt am Main, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Burck","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Radiologie und Nuklearmedizin, Universit\u00e4tsmedizin Frankfurt, Goethe-Universit\u00e4t Frankfurt am Main, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Kessel","sequence":"additional","affiliation":[{"name":"Zentrum der Inneren Medizin, Infektiologie, Universit\u00e4tsmedizin Frankfurt, Goethe-Universit\u00e4t Frankfurt am Main, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Leinung","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Kopf- und Hals- Chirurgie, Universit\u00e4tsmedizin Frankfurt, Goethe-Universit\u00e4t Frankfurt am Main, Frankfurt, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"St\u00f6ver","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Kopf- und Hals- Chirurgie, Universit\u00e4tsmedizin Frankfurt, Goethe-Universit\u00e4t Frankfurt am Main, Frankfurt, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Diensthuber","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Kopf- und Hals- Chirurgie, Universit\u00e4tsmedizin Frankfurt, Goethe-Universit\u00e4t Frankfurt am Main, Frankfurt, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1002\/lary.24440","article-title":"Central skull base osteomyelitis: an emerging clinical entity","volume":"124","author":"AK Johnson","year":"2014","journal-title":"The Laryngoscope"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1097\/00005537-199607000-00003","article-title":"James R. 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