{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:32:29Z","timestamp":1777955549023,"version":"3.51.4"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Sensorineurale H\u00f6rst\u00f6rungen (SNH) sind einer der h\u00e4ufigsten Gr\u00fcnde von Schwerh\u00f6rigkeit. Eine besondere Form der SNH ist die versteckte Schwerh\u00f6rigkeit (HHL) bei subjektiver Normakusis. Aktuelle Forschungsergebnisse deuten darauf hin, dass bei diesen Patienten eine reduzierte Welle I im gemittelten Signal der Hirnstammaudiometrie (ABR) vorliegt. Da die Mittelungstechnik f\u00fcr Latenzjitter und Amplitudenh\u00f6henvariation unempfindlich ist, wird zur Beantwortung einer weitergehenden Fragestellung eine Single-Sweep-Analyse ben\u00f6tigt.<\/jats:p>\n                  <jats:p>Insgesamt wurden 14 M\u00e4use mit signifikant unterschiedlichen Kalziumstr\u00f6men in den IHC bei normvarianter H\u00f6rschwelle f\u00fcr die Analyse genutzt, um im Zeitfenster der Welle I 4 neue Parameter aus den Single Sweeps zu berechnen. Diese dienten gleichzeitig zur Beschreibung einer neuralen Aktivierungsfunktion (NAV).<\/jats:p>\n                  <jats:p>Alle neuen Parameter zeigen im Stimulus-abh\u00e4ngigen Vergleich beim Wildtyp signifikante bzw. hoch signifikante Unterschiede auf. Bei der transgenen Maus sind es signifikante bzw. nicht signifikante Unterschiede. In der neuralen Aktivit\u00e4t des Ruhe-EEGs zwischen der Wildtypmaus und der Mutante gibt es einen signifikanten Unterschied. Die Mittelwerte der Wellenamplituden bei der Wildtypmaus verhalten sich dabei kontrovers.<\/jats:p>\n                  <jats:p>Unter Ausnutzung von Single Sweeps werden innovative Ergebnisse dargestellt, die bis dato so nicht bekannt sind. Offensichtlich ist nicht die Amplitudenh\u00f6he der Welle I f\u00fcr die Funktion der IHC alleinig verantwortlich, sondern besonders noch die neuen Parameter. F\u00fcr die Diagnose von H\u00f6rst\u00f6rungen mit normvarianter H\u00f6rschwelle scheinen die neuen Parameter hervorragend geeignet zu sein.<\/jats:p>","DOI":"10.1055\/a-2681-5401","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:59:29Z","timestamp":1760137169000},"page":"304-314","source":"Crossref","is-referenced-by-count":0,"title":["Neuartige Analysemethode zur Bestimmung der neuralen Aktivierungsfunktion der inneren Haarzelle"],"prefix":"10.1055","volume":"105","author":[{"given":"Dietmar","family":"Hecker","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum des Saarlandes, SL, Germany","place":["Homburg"],"department":["Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Pillong","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum des Saarlandes, SL, Germany","place":["Homburg"],"department":["Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Reuss","sequence":"additional","affiliation":[{"name":"Universit\u00e4t des Saarlandes Medizinische Fakult\u00e4t, SL, Germany","place":["Homburg"],"department":["Fachbereich f\u00fcr HNO"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian Heiko","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Universit\u00e4t des Saarlandes Medizinische Fakult\u00e4t, SL, Germany","place":["Homburg"],"department":["Fachbereich f\u00fcr HNO"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Alexandersson","sequence":"additional","affiliation":[{"name":"Deutsches Forschungszentrum f\u00fcr K\u00fcnstliche Intelligenz GmbH Standort Saarbr\u00fccken, SL, Germany","place":["Saarbr\u00fccken"],"department":["Ambient Assisted Living"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice","family":"Rekrut","sequence":"additional","affiliation":[{"name":"Deutsches Forschungszentrum f\u00fcr K\u00fcnstliche Intelligenz GmbH Standort Saarbr\u00fccken, SL, Germany","place":["Saarbr\u00fccken"],"department":["BCI-Lab"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Linxweiler","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum des Saarlandes, SL, Germany","place":["Homburg"],"department":["Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Bozzato","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum des Saarlandes, SL, Germany","place":["Homburg"],"department":["Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Schick","sequence":"additional","affiliation":[{"name":"Universit\u00e4t des Saarlandes Medizinische Fakult\u00e4t, SL, Germany","place":["Homburg"],"department":["Fachbereich f\u00fcr HNO"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Metzler","sequence":"additional","affiliation":[{"name":"Hochschule RheinMain, HE, Germany","place":["Wiesbaden"],"department":["Ingenieurwissenschaften"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"5647","DOI":"10.3390\/ijms22115647","volume-title":"Molecular mechanisms of sensorineural hearing loss and development of inner ear therapeutics. 2021, MDPI","author":"SM Vlajkovic"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/scientificamerican0815-48","article-title":"Hidden hearing loss","volume":"313","author":"MC Liberman","year":"2015","journal-title":"Scientific American"},{"issue":"01","key":"ref3","doi-asserted-by":"publisher","first-page":"14487","DOI":"10.1038\/ncomms14487","article-title":"Transient auditory nerve demyelination as a new mechanism for hidden hearing loss","volume":"8","author":"G Wan","year":"2017","journal-title":"Nature communications"},{"issue":"04","key":"ref4","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.disamonth.2013.01.005","article-title":"Clinical measures of auditory function: the cochlea and beyond","volume":"59","author":"RR Baiduc","year":"2013","journal-title":"Disease-a-Month"},{"issue":"34","key":"ref5","doi-asserted-by":"publisher","first-page":"13686","DOI":"10.1523\/JNEUROSCI.1783-13.2013","article-title":"Age-related cochlear synaptopathy: an early-onset contributor to auditory functional decline","volume":"33","author":"Y Sergeyenko","year":"2013","journal-title":"Journal of Neuroscience"},{"issue":"03","key":"ref6","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1152\/jn.00164.2013","article-title":"Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates","volume":"110","author":"AC Furman","year":"2013","journal-title":"Journal of neurophysiology"},{"issue":"09","key":"ref7","doi-asserted-by":"publisher","first-page":"e0162726","DOI":"10.1371\/journal.pone.0162726","article-title":"Toward a differential diagnosis of hidden hearing loss in humans","volume":"11","author":"MC Liberman","year":"2016","journal-title":"PloS one"},{"issue":"02","key":"ref8","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1152\/jn.00016.2020","article-title":"Electrophysiological markers of cochlear function correlate with hearing-in-noise performance among audiometrically normal subjects","volume":"124","author":"KJ Grant","year":"2020","journal-title":"Journal of neurophysiology"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"778197","DOI":"10.3389\/fnins.2021.778197","article-title":"Detecting noise-induced cochlear synaptopathy by auditory brainstem response in tinnitus patients with normal hearing thresholds: A meta-analysis","volume":"15","author":"F Chen","year":"2021","journal-title":"Frontiers in neuroscience"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0092-8674(00)00013-1","article-title":"Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channels","volume":"102","author":"J Platzer","year":"2000","journal-title":"Cell"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1142\/9789814532785","volume-title":"Neural regeneration and recovery in the cochlea after excitotoxic injury. In Advances In Hearing Research-Proceedings Of The 10th International Symposium On Hearing. World Scientific","author":"JL Puel","year":"1995"},{"issue":"01","key":"ref12","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/j.1749-6632.1999.tb08646.x","article-title":"Excitotoxicity, synaptic repair, and functional recovery in the mammalian cochlea: a review of recent findings","volume":"884","author":"R Pujol","year":"1999","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"04","key":"ref13","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/S0959-4388(03)00098-9","article-title":"The afferent synapse of cochlear hair cells","volume":"13","author":"PA Fuchs","year":"2003","journal-title":"Current opinion in neurobiology"},{"issue":"45","key":"ref14","doi-asserted-by":"publisher","first-page":"14077","DOI":"10.1523\/JNEUROSCI.2845-09.2009","article-title":"Adding insult to injury: cochlear nerve degeneration after \u201ctemporary\u201d noise-induced hearing loss","volume":"29","author":"SG Kujawa","year":"2009","journal-title":"Journal of Neuroscience"},{"issue":"23","key":"ref15","doi-asserted-by":"publisher","first-page":"e114587","DOI":"10.15252\/embj.2023114587","article-title":"Diversity matters \u2013 extending sound intensity coding by inner hair cells via heterogeneous synapses","volume":"42","author":"T Moser","year":"2023","journal-title":"The EMBO Journal"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.heares.2017.01.003","article-title":"Cochlear synaptopathy in acquired sensorineural hearing loss: Manifestations and mechanisms","volume":"349","author":"MC Liberman","year":"2017","journal-title":"Hearing research"},{"issue":"02","key":"ref17","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1097\/AUD.0000000000000107","article-title":"Auditory function in normal-hearing, noise-exposed human ears","volume":"36","author":"GC Stamper","year":"2015","journal-title":"Ear and hearing"},{"issue":"38","key":"ref18","doi-asserted-by":"publisher","first-page":"13452","DOI":"10.1523\/JNEUROSCI.2156-11.2011","article-title":"Tinnitus with a normal audiogram: physiological evidence for hidden hearing loss and computational model","volume":"31","author":"R Schaette","year":"2011","journal-title":"Journal of Neuroscience"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.heares.2015.02.009","article-title":"Synaptopathy in the noise-exposed and aging cochlea: Primary neural degeneration in acquired sensorineural hearing loss","volume":"330","author":"SG Kujawa","year":"2015","journal-title":"Hearing research"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.heares.2015.04.008","article-title":"No longer falling on deaf ears: mechanisms of degeneration and regeneration of cochlear ribbon synapses","volume":"329","author":"G Wan","year":"2015","journal-title":"Hearing research"},{"key":"ref21","volume-title":"New handbook of auditory evoked responses. Hrsg. Pearson Education, Inc. 2007. ISBN: 978\u20130-205\u201336104\u20135","author":"JW Hall"},{"key":"ref22","doi-asserted-by":"publisher","volume-title":"Signaltheorie. Hrsg. Springer Vieweg Wiesbaden; 2023. ISBN: 978\u20133-658\u201341528\u20130","author":"A Mertins","DOI":"10.1007\/978-3-658-41529-7"},{"issue":"23","key":"ref23","doi-asserted-by":"publisher","first-page":"7124","DOI":"10.3390\/jcm11237124","article-title":"Identification of Neural Mechanisms in First Single-Sweep Analysis in oVEMPs and Novel Normative Data","volume":"11","author":"DJ Hecker","year":"2022","journal-title":"Journal of Clinical Medicine"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1055\/a-2520-3439","article-title":"Ver\u00e4nderte neuronale Verarbeitung von oVEMPs bei Patienten mit Multiple Sklerose","author":"L Schulte-G\u00f6bel","year":"2025","journal-title":"Laryngo-Rhino-Otologie"},{"issue":"01","key":"ref25","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1109\/TNSRE.2013.2252627","article-title":"Electromotive triggering and single sweep analysis of vestibular evoked myogenic potentials (VEMPs)","volume":"22","author":"DJ Hecker","year":"2013","journal-title":"IEEE Transactions on Neural Systems and Rehabilitation Engineering"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00225","article-title":"Cochlea-Specific Deletion of Cav1.3 Calcium Channels Arrests Inner Hair Cell Differentiation and Unravels Pitfalls of Conditional Mouse Models","volume":"13","author":"S Eckrich","year":"2019","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.heares.2016.05.004","article-title":"Loss of glycine receptors containing the \u03b13 subunit compromises auditory nerve activity, but not outer hair cell function","volume":"337","author":"J Dlugaiczyk","year":"2016","journal-title":"Hearing research"},{"key":"ref28","volume-title":"Taschenbuch der Mathematik. Vol. 6. Hrsg: Harri Deutsch 2005, ISBN: 978\u20133-8171\u20132006\u20132","author":"IN Bronstein"},{"issue":"05","key":"ref29","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1213\/ANE.0000000000002864","article-title":"Correlation coefficients: appropriate use and interpretation","volume":"126","author":"P Schober","year":"2018","journal-title":"Anesthesia & analgesia"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1109\/CNE.2007.369754","article-title":"Ultra-fast detection of hearing thresholds by single sweeps of auditory brainstem responses: A new novelty detection paradigm. in 2007 3rd International IEEE\/EMBS Conference on Neural Engineering","author":"FI Corona-Strauss","year":"2007","journal-title":"IEEE"},{"issue":"S 02","key":"ref31","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1728469","article-title":"Using intelligent algorithms on singlesweeps to evaluate thresholds and waveforms of brainstem evoked response audiometry (BERA)","volume":"100","author":"D Hecker","year":"2021","journal-title":"Laryngo-Rhino-Otologie"},{"issue":"11","key":"ref32","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1055\/a-1893-6992","article-title":"Bera and VEMPs \u2013 Is that it or can we do better?","volume":"41","author":"D Hecker","year":"2022","journal-title":"Nervenheilkunde"},{"issue":"01","key":"ref33","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1109\/TNSRE.2007.911086","article-title":"Objective quantification of the tinnitus decompensation by synchronization measures of auditory evoked single sweeps","volume":"16","author":"DJ Strauss","year":"2008","journal-title":"IEEE Transactions on Neural Systems and Rehabilitation Engineering"},{"issue":"10","key":"ref34","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1007\/s00439-023-02595-5","article-title":"The natural history, clinical outcomes, and genotype\u2013phenotype relationship of otoferlin-related hearing loss: a systematic, quantitative literature review","volume":"142","author":"CL Ford","year":"2023","journal-title":"Human Genetics"},{"issue":"02","key":"ref35","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1002\/hbm.25238","article-title":"Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus","volume":"42","author":"L Lan","year":"2021","journal-title":"Human Brain Mapping"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1007\/s10162-015-0539-3","article-title":"Towards a diagnosis of cochlear neuropathy with envelope following responses","volume":"16","author":"LA Shaheen","year":"2015","journal-title":"Journal of the Association for Research in Otolaryngology"}],"container-title":["Laryngo-Rhino-Otologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2681-5401.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:34:44Z","timestamp":1777934084000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2681-5401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,10]]},"references-count":36,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2026,5,4]]},"published-print":{"date-parts":[[2026,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2681-5401","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0935-8943","1438-8685"],"issn-type":[{"value":"0935-8943","type":"print"},{"value":"1438-8685","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,10]]}}}