{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T10:15:59Z","timestamp":1764324959736,"version":"3.46.0"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Im Rahmen eines vom Bundesministerium f\u00fcr Ern\u00e4hrung und Landwirtschaft (BMEL)\n                    (jetzt: Bundesministerium f\u00fcr Landwirtschaft, Ern\u00e4hrung und Heimat [BMLEH])\n                    gef\u00f6rderten Verbundprojekts (\u201eHKP-Mon\u201c) hatten wir die M\u00f6glichkeit, auf einen\n                    gro\u00dfen Datensatz von Resistenztestungen des Veterin\u00e4rdiagnostikunternehmens\n                    Laboklin zuzugreifen. Insgesamt standen uns zur Auswertung 175\u2009171 Ergebnisse\n                    aus den Jahren 2019 bis 2021 zur Verf\u00fcgung. Dieser Datensatz wurde zur\n                    Auswertung von bei Hund und Katze pathogenen bakteriellen Erregern und deren\n                    Resistenzsituation genutzt. Es werden Ergebnisse zu Methicillin-resistenten\n                        Staphylococcus (S.) aureus (MRSA), S. pseudintermedius\n                    (MRSP), Drittgeneration-Cephalosporin-resistenten (3GCR) Escherichia (E.)\n                        coli, 3GCR Klebsiella (K.) pneumoniae und\n                        Pseudomonas (P.) aeruginosa vorgestellt. Etwa 15% (Katzen) bis 20%\n                    (Hunde) der S. aureus-Isolate wurden als MRSA charakterisiert. Bei S.\n                        pseudintermedius lag die MRSP-Pr\u00e4valenz bei etwa 7% bei Hunden und bei\n                    Katzen mit etwa 16% deutlich h\u00f6her. Bei circa 12% (vergleichbar bei Hund und\n                    Katze) der E. coli-St\u00e4mme zeigte sich eine Resistenz gegen ein\n                    Cephalosporin der 3. Generation, und die 3GCR K. pneumoniae-Pr\u00e4valenz lag\n                    bei Hunden bei 15% und bei Katzen bei 26%. Aufgrund der nat\u00fcrlichen\n                    (intrinsischen) Resistenzen von P. aeruginosa gegen\u00fcber einer Vielzahl\n                    von Antibiotikaklassen stehen in der Tiermedizin neben Colistin\/Polymyxin B\n                    lediglich Aminoglykoside und Fluorchinolone als therapeutische Wirkstoffgruppen\n                    zur Verf\u00fcgung.<\/jats:p>\n                  <jats:p>Die hier beschriebenen multiresistenten Bakterien stellen somit in\n                    therapeutischer Hinsicht eine erhebliche Herausforderung dar. Oft bleiben in\n                    Abh\u00e4ngigkeit vom Infektionsort nur wenige Behandlungsm\u00f6glichkeiten \u00fcbrig. Daher\n                    sind eine sorgf\u00e4ltige Diagnostik und korrekte Interpretation der\n                    mikrobiologischen Ergebnisse essenziell, um die Wirksamkeit der Antibiotika zu\n                    erhalten und die Entwicklung von weiteren Antibiotikaresistenzen zu\n                    minimieren.<\/jats:p>","DOI":"10.1055\/a-2685-0834","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T22:34:36Z","timestamp":1760567676000},"page":"288-297","source":"Crossref","is-referenced-by-count":0,"title":["Resistenzlage einiger kleintierpathogener Bakterien und prudent use\n                    of antibiotics \u2013 wie bringe ich dies zusammen?"],"prefix":"10.1055","volume":"53","author":[{"given":"Wolfgang","family":"B\u00e4umer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pharmakologie und Toxikologie, Fachbereich\n                    Veterin\u00e4rmedizin, Freie Universit\u00e4t Berlin"},{"name":"Tiermedizinisches Zentrum f\u00fcr Resistenzforschung, Fachbereich\n                    Veterin\u00e4rmedizin, Freie Universit\u00e4t Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roswitha","family":"Merle","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Epidemiologie und Biometrie, Fachbereich Veterin\u00e4rmedizin,\n                    Freie Universit\u00e4t Berlin"},{"name":"Tiermedizinisches Zentrum f\u00fcr Resistenzforschung, Fachbereich\n                    Veterin\u00e4rmedizin, Freie Universit\u00e4t Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonie","family":"Feuer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pharmakologie und Toxikologie, Fachbereich\n                    Veterin\u00e4rmedizin, Freie Universit\u00e4t Berlin"},{"name":"Tiermedizinisches Zentrum f\u00fcr Resistenzforschung, Fachbereich\n                    Veterin\u00e4rmedizin, Freie Universit\u00e4t Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Frenzer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Epidemiologie und Biometrie, Fachbereich Veterin\u00e4rmedizin,\n                    Freie Universit\u00e4t Berlin"},{"name":"Tiermedizinisches Zentrum f\u00fcr Resistenzforschung, Fachbereich\n                    Veterin\u00e4rmedizin, Freie Universit\u00e4t Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antina","family":"L\u00fcbke-Becker","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Mikrobiologie und Tierseuchen, Fachbereich\n                    Veterin\u00e4rmedizin, Freie Universit\u00e4t Berlin"},{"name":"Tiermedizinisches Zentrum f\u00fcr Resistenzforschung, Fachbereich\n                    Veterin\u00e4rmedizin, Freie Universit\u00e4t Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"ref4","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1128\/CMR.10.3.505","article-title":"Nasal carriage of Staphylococcus aureus: epidemiology, underlying\n                    mechanisms, and associated risks","volume":"10","author":"J Kluytmans","year":"1997","journal-title":"Clin Microbiol Rev"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1146\/annurev.mi.34.100180.003015","article-title":"Natural Populations of the Genus Staphylococcus","volume":"34","author":"W E Kloos","year":"1980","journal-title":"Annu Rev Microbiol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.3390\/antibiotics12071137","article-title":"Multi-Host Pathogen Staphylococcus aureus\u2013Epidemiology, Drug Resistance\n                    and Occurrence in Humans and Animals in Poland","volume":"12","author":"A Tro\u015bcia\u0144czyk","year":"2023","journal-title":"Antibiotics"},{"volume-title":"Staphylococcus. 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