{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:30Z","timestamp":1787004870200,"version":"build-2736575974"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Epilepsy significantly impacts the health-related quality of life (HRQoL) of children and adolescents (CaA). This study aimed to assess HRQoL in pediatric epilepsy patients compared to their healthy peers, using both self- and proxy-reports, and to identify specific HRQoL domains affected by epilepsy.<\/jats:p>\n                  <jats:p>A single-center, cross-sectional study was conducted in Munich between October 2021 and June 2023. HRQoL was assessed in 139 patients aged 3 to 17 years with medically diagnosed epilepsy using age-adapted, validated KINDL\u00a9 questionnaires, completed by the patients and one caregiver. The questionnaire comprised six subscales: \u201cPhysical Well-being,\u201d \u201cEmotional Well-being,\u201d \u201cSelf-Esteem,\u201d \u201cFamily,\u201d \u201cFriends,\u201d and \u201cEveryday Functioning.\u201d Control values from healthy CaA aged 7 to 17 were drawn from the BELLA and KiGGS studies. Welch tests and Wilcoxon signed-rank tests were used for statistical comparisons.<\/jats:p>\n                  <jats:p>Compared to their healthy peers, CaA with epilepsy reported significantly lower HRQoL overall, particularly in the subscales \u201cPhysical Well-being,\u201d \u201cEmotional Well-being,\u201d and \u201cFriends.\u201d No significant differences were observed in the \u201cFamily\u201d subscale. Interestingly, self-reports revealed a trend toward higher \u201cSelf-Esteem\u201d scores among CaA with epilepsy, though this did not reach statistical significance. No significant differences emerged between self- and proxy-reported total HRQoL scores.<\/jats:p>\n                  <jats:p>Epilepsy in CaA is associated with reduced HRQoL, especially in physical, emotional, and social domains. Stable family support can cushion some negative effects. In particular, the unexpectedly high results in the area of self-confidence should be the subject of future research.<\/jats:p>","DOI":"10.1055\/a-2686-0818","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T23:11:01Z","timestamp":1755645061000},"page":"027-034","source":"Crossref","is-referenced-by-count":1,"title":["Quality of Life of Children and Adolescents with Epilepsy Compared to Their Healthy Peers: A Cross-Sectional Study"],"prefix":"10.1055","volume":"57","author":[{"given":"Robert","family":"Opitz","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Hospital, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Gerstner","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Hospital, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"M\u00fche","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Hospital, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7584-0811","authenticated-orcid":false,"given":"Malin","family":"Zaddach","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Hospital, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6277-3218","authenticated-orcid":false,"given":"Leonie","family":"Grosse","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Hospital, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1925-7538","authenticated-orcid":false,"given":"Katharina","family":"Vill","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Hospital, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2832-0156","authenticated-orcid":false,"given":"Astrid","family":"Bertsche","sequence":"additional","affiliation":[{"name":"Department of Neuropaediatrics, University Medicine Greifswald, Greifswald, Germany"},{"name":"German Center for Child and Adolescent Health (DZKJ), Partner Site Greifswald\/Rostock, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8484-5945","authenticated-orcid":false,"given":"Ingo","family":"Borggraefe","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Hospital, Munich, Germany"},{"name":"Comprehensive Epilepsy Center, Ludwig-Maximilians-University Hospital, Munich, 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Fisher","year":"2014","journal-title":"Epilepsia"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1367\/A03-178R.1","article-title":"Evidence that school-age children can self-report on their health","volume":"4","author":"A W Riley","year":"2004","journal-title":"Ambul Pediatr"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1111\/epi.12772","article-title":"Risk factors for health-related quality of life in children with epilepsy: a meta-analysis","volume":"55","author":"M A Ferro","year":"2014","journal-title":"Epilepsia"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.seizure.2014.09.003","article-title":"The perceived burden of epilepsy: Impact on the quality of life of children and adolescents and their families","volume":"24","author":"C Cianchetti","year":"2015","journal-title":"Seizure"},{"issue":"15","key":"ref7","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1212\/WNL.0b013e31826e25aa","article-title":"Quality of life in children with new-onset epilepsy: a 2-year prospective cohort study","volume":"79","author":"K N Speechley","year":"2012","journal-title":"Neurology"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S1525-5050(02)00601-7","article-title":"Quality of life in pediatric epilepsy: demographic and disease-related predictors and comparison with healthy controls","volume":"4","author":"V Miller","year":"2003","journal-title":"Epilepsy Behav"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1477-7525-7-77","article-title":"Measuring adolescents' HRQoL via self reports and parent proxy reports: an evaluation of the psychometric properties of both versions of the KINDL-R instrument","volume":"7","author":"M Erhart","year":"2009","journal-title":"Health Qual Life Outcomes"},{"issue":"S 01","key":"ref10","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s00787-008-1016-x","article-title":"Health-related quality of life in children and adolescents in Germany: results of the BELLA study","volume":"17","author":"U Ravens-Sieberer","year":"2008","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"ref11","first-page":"810","article-title":"[Health-related quality of life of children and adolescents in Germany. Norm data from the German Health Interview and Examination Survey (KiGGS)]","volume":"50","author":"U Ravens-Sieberer","year":"2007","journal-title":"Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz"},{"issue":"05","key":"ref12","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1023\/A:1008853819715","article-title":"Assessing health-related quality of life in chronically ill children with the German KINDL: first psychometric and content analytical results","volume":"7","author":"U Ravens-Sieberer","year":"1998","journal-title":"Qual Life Res"},{"issue":"04","key":"ref13","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1177\/0004563221992088","article-title":"Best practice in statistics: Use the Welch t-test when testing the difference between two groups","volume":"58","author":"R M West","year":"2021","journal-title":"Ann Clin Biochem"},{"issue":"04","key":"ref14","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/beheco\/ark016","article-title":"The unequal variance t-test is an underused alternative to Student's t-test and the Mann\u2013Whitney U test","volume":"17","author":"G D Ruxton","year":"2006","journal-title":"Behav Ecol"},{"issue":"03","key":"ref15","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/epi4.12765","article-title":"Assessment of self-stigma in epilepsy: Validation of the German version Epilepsy Self-Stigma Scale (ESSS-G)","volume":"8","author":"I Kuramochi","year":"2023","journal-title":"Epilepsia Open"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.yebeh.2016.04.011","article-title":"Attention and executive functions in the early course of pediatric epilepsy","volume":"60","author":"G Reuner","year":"2016","journal-title":"Epilepsy Behav"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.yebeh.2016.06.006","article-title":"Executive function and health-related quality of life in pediatric epilepsy","volume":"62","author":"W A Schraegle","year":"2016","journal-title":"Epilepsy Behav"},{"issue":"05","key":"ref18","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1469-8749.2008.03172.x","article-title":"Prevalence of psychopathology in childhood epilepsy: categorical and dimensional measures","volume":"51","author":"D W Dunn","year":"2009","journal-title":"Dev Med Child Neurol"},{"issue":"02","key":"ref19","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s11060-016-2113-1","article-title":"Executive dysfunction is associated with poorer health-related quality of life in pediatric brain tumor survivors","volume":"128","author":"K L Netson","year":"2016","journal-title":"J Neurooncol"},{"issue":"04","key":"ref20","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3102\/00346543063004449","article-title":"Exploring the link between giftedness and self-concept","volume":"63","author":"R D Hoge","year":"1993","journal-title":"Rev Educ Res"},{"issue":"09","key":"ref21","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1111\/epi.17006","article-title":"Self-esteem mediates mental health outcomes in young people with epilepsy","volume":"62","author":"P T Cahill","year":"2021","journal-title":"Epilepsia"},{"issue":"04","key":"ref22","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/nur.21725","article-title":"Family functioning and the well-being of children with chronic conditions: a meta-analysis","volume":"39","author":"J Leeman","year":"2016","journal-title":"Res Nurs Health"},{"issue":"11","key":"ref23","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s40273-022-01177-z","article-title":"Are we agreed? 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