{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:58:33Z","timestamp":1785283113130,"version":"3.55.0"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Was ist neu?<\/jats:title>\n                  <jats:p>Im Jahr 2025 verabschiedete die Weltgesundheitsorganisation (WHO) eine Resolution zur St\u00e4rkung der Nierengesundheit; im selben Jahr erkannten die Vereinten Nationen (UN) die chronische Nierenkrankheit (CKD) erstmals offiziell als eine der h\u00e4ufigsten und folgenschwersten nicht\u00fcbertragbaren Erkrankungen an. Angesichts weltweit steigender Pr\u00e4valenz und Mortalit\u00e4t fordern die UN verst\u00e4rkte Ma\u00dfnahmen zur Pr\u00e4vention, Fr\u00fcherkennung und Versorgung der CKD.<\/jats:p>\n                  <jats:p>Weltweit leben rund 800 Millionen Erwachsene mit CKD, was einer altersstandardisierten Pr\u00e4valenz von etwa 14% entspricht. Der \u00fcberwiegende Teil der Betroffenen befindet sich in fr\u00fchen Krankheitsstadien, fortgeschrittene Stadien betreffen vor allem \u00e4ltere und klinisch vulnerable Populationen. CKD verursachte 2023 etwa 1,5 Millionen Todesf\u00e4lle und geh\u00f6rt zu den wenigen gro\u00dfen Krankheitsentit\u00e4ten mit weiter steigender altersstandardisierter Mortalit\u00e4t. Die CKD-assoziierte Krankheitslast wird \u00fcberwiegend durch metabolische Risikofaktoren bestimmt, insbesondere arterielle Hypertonie, Diabetes mellitus und Adipositas. In ressourcen\u00e4rmeren Regionen tragen zus\u00e4tzlich Umwelt-, Berufs- und Versorgungsfaktoren wesentlich zur Krankheitsentstehung und -progression bei.<\/jats:p>\n                  <jats:p>CKD im Kindesalter ist selten, geht jedoch aufgrund der langen Krankheitsdauer mit einer erheblichen lebenslangen Krankheitslast einher. Registerbasierte Daten untersch\u00e4tzen vermutlich die tats\u00e4chliche Pr\u00e4valenz, da fr\u00fche Stadien h\u00e4ufig unerkannt bleiben. H\u00e4ufigste Ursachen sind angeborene Fehlbildungen der Nieren und ableitenden Harnwege sowie heredit\u00e4re Nephropathien. Perinatale Faktoren und fr\u00fchkindliche Nierensch\u00e4digungen erh\u00f6hen das Risiko einer sp\u00e4teren CKD.<\/jats:p>\n                  <jats:p>Die CKDu stellt ein relevantes globales Gesundheitsproblem dar, insbesondere in landwirtschaftlich gepr\u00e4gten Regionen von L\u00e4ndern niedrigen Einkommens. Betroffen sind vor allem j\u00fcngere Erwachsene ohne klassische Risikofaktoren; als m\u00f6gliche Ursachen werden Hitzestress, Dehydration und Umwelttoxine diskutiert.<\/jats:p>\n                  <jats:p>werden voraussichtlich zu einer Pr\u00e4valenzabnahme von CKD-Stadien 4 und 5 sowie des Anteils der dialysepflichtigen Patientinnen und Patienten f\u00fchren. Ausschlaggebend f\u00fcr die Verringerung fr\u00fcherer CKD-Stadien werden pr\u00e4ventive Ma\u00dfnahmen sein.<\/jats:p>","DOI":"10.1055\/a-2687-3360","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:38:29Z","timestamp":1780094309000},"page":"639-644","source":"Crossref","is-referenced-by-count":0,"title":["Die Endemie der chronischen Nierenkrankheit"],"prefix":"10.1055","volume":"151","author":[{"given":"Elke","family":"Schaeffner","sequence":"additional","affiliation":[{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Institute of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"ref3","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1016\/S0140-6736(24)00685-8","article-title":"Burden of disease scenarios for 204 countries and territories, 2022\u20132050: a forecasting analysis for the Global Burden of Disease Study 2021","volume":"403","author":"Global Burden of Diseases 2021 Forecasting Collaborators","year":"2024","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1016\/S0140-6736(25)01853-7","article-title":"Global, regional, and national burden of chronic kidney disease in adults, 1990\u20132023, and its attributable risk factors: a systematic analysis for the Global Burden of Disease Study 2023","volume":"406","author":"Global Burden of Diseases CKD Collaborators","year":"2025","journal-title":"Lancet"},{"issue":"04","key":"ref5","doi-asserted-by":"publisher","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","article-title":"KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease","volume":"105","author":"Kidney Disease: Improving Global Outcomes, CKD Work Group","year":"2024","journal-title":"Kidney Int"},{"issue":"03","key":"ref6","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/nrneph.2017.181","article-title":"Sex and gender disparities in the epidemiology and outcomes of chronic kidney disease","volume":"14","author":"JJ Carrero","year":"2018","journal-title":"Nat Rev Nephrol"},{"issue":"10","key":"ref7","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1681\/ASN.2019030238","article-title":"CKD: A Call for an Age-Adapted Definition","volume":"30","author":"P Delanaye","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"395","author":"Global Burden of Diseases CKD Collaborators","year":"2020","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/S0140-6736(20)30752-2","article-title":"Global burden of 87 risk factors in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","author":"Global Burden of Diseases Risk Factors Collaborators","year":"2020","journal-title":"Lancet"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1016\/S0140-6736(24)00933-4","article-title":"Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990\u20132021: a systematic analysis for the Global Burden of Disease Study 2021","volume":"403","author":"Global Burden of Diseases Risk Factors Collaborators","year":"2024","journal-title":"Lancet"},{"issue":"01","key":"ref12","first-page":"15","article-title":"Overweight and obesity among children and adolescents in Germany. 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