{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:53:25Z","timestamp":1762905205522,"version":"3.45.0"},"reference-count":49,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aktuelle Urol"],"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die strahleninduzierte Zystitis ist eine h\u00e4ufige Komplikation nach Strahlentherapien bei Beckenkarzinomen (z.B. Prostata, Blase, Zervix). Ihre Akuttoxizit\u00e4t betr\u00e4gt bis zu 50%, Sp\u00e4ttoxizit\u00e4t 5\u201311%. Zu den Ausl\u00f6sern z\u00e4hlen die Strahlendosis, Therapieplanung und patientenabh\u00e4ngige Faktoren wie Strahlensensibilit\u00e4t, Vorerkrankungen und Tabakkonsum. Die Erkrankung f\u00fchrt zu inflammatorischen und fibrotischen Ver\u00e4nderungen der Blasenschleimhaut, welche Symptome wie Dysurie und H\u00e4maturie verursachen.<\/jats:p>\n                  <jats:p>Dieser Review gibt einen \u00dcberblick \u00fcber die verf\u00fcgbaren Therapieoptionen zur Behandlung der strahleninduzierten Zystitis. Dabei werden konservative, medikament\u00f6se, interventionelle und chirurgische Ans\u00e4tze beschrieben und hinsichtlich ihrer Effektivit\u00e4t, Sicherheit und Indikationen bewertet.<\/jats:p>\n                  <jats:p>Bei der Akuttoxizit\u00e4t steht eine symptomorientierte konservativ-medikament\u00f6se Behandlung im Vordergrund. Intravesikale Optionen wie Hyalurons\u00e4ure und Alaunl\u00f6sung zeigen in Studien moderate Ansprechraten. Die hyperbare Oxygenierung erzielt mit 64\u2013100% partieller Remission und geringen Nebenwirkungen vielversprechende Ergebnisse. Invasivere Optionen wie Embolisation und Zystektomie bleiben Ultima Ratio, da sie mit hohen perioperativen Risiken verbunden sind.<\/jats:p>\n                  <jats:p>Die Therapie der strahleninduzierten Zystitis erfordert ein multimodales Vorgehen. Durch Standardisierung des Therapiealgorithmus k\u00f6nnen Wege gefunden werden, um Patientenergebnisse zu verbessern.<\/jats:p>","DOI":"10.1055\/a-2687-7722","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:49:43Z","timestamp":1762904983000},"source":"Crossref","is-referenced-by-count":0,"title":["Folgen der Strahlentherapie an der Harnblase: Therapieoptionen"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1166-7778","authenticated-orcid":false,"given":"Simon","family":"Gloger","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Urologie, Augusta-Kranken-Anstalt gGmbH, Bochum, Germany"},{"name":"Fakult\u00e4t f\u00fcr Gesundheit, Universit\u00e4t Witten\/Herdecke, Witten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4960-7498","authenticated-orcid":false,"given":"Andreas","family":"Wiedemann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Urologie, Ev. Krankenhaus Witten gGmbh, Witten, Germany"},{"name":"Lehrstuhl f\u00fcr Geriatrie, Universitat Witten\/Herdecke Department fur Humanmedizin, Witten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burkhard","family":"Ubrig","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Urologie, Augusta-Kranken-Anstalt gGmbH, Bochum, Germany"},{"name":"Fakult\u00e4t f\u00fcr Gesundheit, Universit\u00e4t Witten\/Herdecke, Witten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/NRUROL.2010.23","article-title":"Management of radiation cystitis","volume":"7","author":"SG Smit","year":"2010","journal-title":"Nat Rev Urol"},{"issue":"S 3","key":"ref2","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/BJU.14145","article-title":"Radiotherapy-related complications presenting to a 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