{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T23:11:19Z","timestamp":1760742679282,"version":"build-2065373602"},"reference-count":57,"publisher":"Georg Thieme Verlag KG","issue":"09","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation\n                        of China","doi-asserted-by":"crossref","award":["81102125"],"award-info":[{"award-number":["81102125"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aims to clarify the relationship between body mass index, body\n                    composition indices, and the risk of insulin resistance. From November 2019 to\n                    January 2020, 573 employees aged 40\u201360 years from Anhui Hong Sifang Co., Ltd,\n                    underwent physical and biochemical assessments. We analyzed fasting glucose,\n                    serum insulin, and homeostasis model assessment of insulin resistance\n                    differences across body mass index and body composition, and examined\n                    associations with insulin resistance risk. Among 573 participants (mean age 48.3\n                    years, 67.4% men), 20.8% had insulin resistance. Overweight\/obesity, central\n                    obesity, high visceral adipose index, high fat mass%, limb\/trunk fat%, and\n                    elevated fat-muscle-ratio were significantly associated with higher fasting\n                    serum insulin, homeostasis model assessment of insulin resistance, and insulin\n                    resistance prevalence (all p&lt;0.05). The increase in these factors\n                    corresponded with increased insulin resistance risk, with odds ratios and 95%\n                    confidence intervals of 4.71 (2.88\u20137.72), 5.80 (3.60\u20139.35), 4.88 (3.07\u20137.74),\n                    4.25 (2.71\u20136.69), 3.48 (2.19\u20135.52), 5.72 (3.45\u20139.47), and 4.41 (2.73\u20137.13).\n                    Conversely, lower muscle mass%, limb\/trunk muscle%, bone mineral content%, total\n                    body water%, extracellular water%, and intracellular water% were linked to\n                    higher fasting serum insulin and homeostasis model assessment of insulin\n                    resistance, indicating a protective effect against insulin resistance with odds\n                    ratios and 95% confidence intervals of 4.34 (2.67\u20137.08), 3.53 (2.21\u20135.62), 3.49\n                    (2.20\u20135.53), 5.35 (3.24\u20138.85), 4.73 (2.91\u20137.70), 4.99 (3.06\u20138.16), and 4.98\n                    (3.04\u20138.14). The findings suggest a significant association between body\n                    composition indices and insulin resistance risk. Increased fat mass raises the\n                    risk of insulin resistance, while higher muscle mass, bone mineral content, and\n                    body water content have a protective effect. Additionally, the balance between\n                    fat and muscle influences insulin resistance levels.<\/jats:p>","DOI":"10.1055\/a-2691-0442","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T22:46:49Z","timestamp":1760741209000},"page":"520-528","source":"Crossref","is-referenced-by-count":0,"title":["Association of Body Composition with Insulin Resistance in a\n                    Middle-Aged Population"],"prefix":"10.1055","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3551-4306","authenticated-orcid":false,"given":"Ke","family":"Zhou","sequence":"first","affiliation":[{"name":"School of Public Health, Anhui Medical University,\n                    Hefei, China"},{"name":"Key Laboratory of Population Health Across Life Cycle, Ministry of\n                    Education of the People\u2019s Republic of China, Hefei, China"},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract,\n                    Hefei, China"},{"name":"Anhui Provincial Key Laboratory of Population Health and Aristogenics,\n                    Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyan","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Public Health, Anhui Medical University,\n                    Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengru","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Public Health, Anhui Medical University,\n                    Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingfang","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Public Health, Anhui Medical University,\n                    Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Kang","sequence":"additional","affiliation":[{"name":"School of Public Health, Anhui Medical University,\n                    Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangping","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health, Anhui Medical University,\n                    Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufan","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Public Health, Anhui Medical University,\n                    Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hongguang Street Community Health Service Center, Hefei,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaojiao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Hongguang Street Community Health Service Center, Hefei,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zheng","sequence":"additional","affiliation":[{"name":"Hongguang Street Community Health Service Center, Hefei,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aixia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hongguang Street Community Health Service Center, Hefei,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Sheng","sequence":"additional","affiliation":[{"name":"School of Public Health, Anhui Medical University,\n                    Hefei, China"},{"name":"Key Laboratory of Population Health Across Life Cycle, Ministry of\n                    Education of the People\u2019s Republic of China, Hefei, China"},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract,\n                    Hefei, China"},{"name":"Anhui Provincial Key Laboratory of Population Health and Aristogenics,\n                    Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Liu","sequence":"additional","affiliation":[{"name":"Hongguang Street Community Health Service Center, Hefei,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2503-961X","authenticated-orcid":false,"given":"Sufang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health, Anhui Medical University,\n                    Hefei, China"},{"name":"Key Laboratory of Population Health Across Life Cycle, Ministry of\n                    Education of the People\u2019s Republic of China, Hefei, China"},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract,\n                    Hefei, China"},{"name":"Anhui Provincial Key Laboratory of Population Health and Aristogenics,\n                    Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/hep.30429","article-title":"Modulation of insulin resistance in nonalcoholic fatty liver disease","volume":"70","author":"R S Khan","year":"2019","journal-title":"Hepatology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.2147\/DMSO.S275898","article-title":"Obesity, insulin resistance, and type 2 diabetes: associations and therapeutic\n                    implications","volume":"13","author":"Y T Wondmkun","year":"2020","journal-title":"Diabetes Metab Syndr Obes"},{"key":"ref3","first-page":"36","article-title":"Obesity- insulin resistance and diabetes. 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Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2691-0442.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T22:47:07Z","timestamp":1760741227000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2691-0442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":57,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2025,10,17]]},"published-print":{"date-parts":[[2025,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2691-0442","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]}}}