{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T22:56:10Z","timestamp":1775861770791,"version":"3.50.1"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"06","funder":[{"name":"PI: B.A.S.","award":["K23 HD097254"],"award-info":[{"award-number":["K23 HD097254"]}]},{"name":"Co-PIs K.D.F. and B.A.S., Co-I: D.E.L.","award":["R01 HD072071"],"award-info":[{"award-number":["R01 HD072071"]}]},{"name":"PI: Z.A.V.","award":["K23NS111086"],"award-info":[{"award-number":["K23NS111086"]}]},{"name":"PI: C.P.T.","award":["K23HL157618"],"award-info":[{"award-number":["K23HL157618"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Late-onset neonatal sepsis (LOS) in very low birth weight (VLBW) preterm infants varies in severity from mild to fatal and often presents with cardiorespiratory instability. We hypothesized that heart rate (HR) and systemic oxygenation (SpO2) patterns would differ based on pathogen type and mortality.<\/jats:p>\n                  <jats:p>We analyzed HR and SpO2 changes before LOS diagnosis for Gram-negative, Coagulase-negative Staphylococcus, and other Gram-positive bacteria (GN, CONS, OGP) and compared survivors and nonsurvivors. Using continuous every-2-second vital sign data from 365 VLBW infants in four neonatal intensive care units, we calculated nine HR and SpO2 metrics over a 96-hour window.<\/jats:p>\n                  <jats:p>GN LOS was associated with a slightly higher HR, more negative skewness of HR, and higher cross correlation of HR-SpO2. Mortality was highest in GN LOS (22.7 vs. 4.6% CONS, 8.8% OGP). Nonsurvivors had distinct HR and SpO2 patterns.<\/jats:p>\n                  <jats:p>These findings highlight critical cardiorespiratory differences at LOS diagnosis associated with mortality risk.<\/jats:p>","DOI":"10.1055\/a-2693-0426","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T23:45:07Z","timestamp":1757720707000},"page":"794-799","source":"Crossref","is-referenced-by-count":0,"title":["Organism- and Mortality-Specific Cardiorespiratory Patterns in Late-Onset Neonatal Sepsis: A Four-Neonatal Intensive Care Unit Study of Very Low Birth Weight Infants"],"prefix":"10.1055","volume":"43","author":[{"given":"Sherry L.","family":"Kausch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brynne A.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Sahni","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary A.","family":"Vesoulis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colm P.","family":"Travers","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas E.","family":"Lake","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen D.","family":"Fairchild","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Predictive Monitoring Consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"e2022058813","DOI":"10.1542\/peds.2022-058813","article-title":"Late-onset sepsis among very preterm infants","volume":"150","author":"D D 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