{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T08:40:21Z","timestamp":1771058421977,"version":"3.50.1"},"reference-count":115,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"DOI":"10.13039\/501100004571","name":"French Ministry of Social Affairs and Health","doi-asserted-by":"crossref","award":["P070128"],"award-info":[{"award-number":["P070128"]}],"id":[{"id":"10.13039\/501100004571","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Program d'Investissements d'Avenir","award":["ANR-18-RHUS-0004"],"award-info":[{"award-number":["ANR-18-RHUS-0004"]}]},{"name":"France 2030","award":["IAHU-0004-PROMETHEUS"],"award-info":[{"award-number":["IAHU-0004-PROMETHEUS"]}]},{"name":"ERA PerMed","award":["JTC_2021"],"award-info":[{"award-number":["JTC_2021"]}]},{"name":"Chinese National Scientific Foundation Committee","award":["82172154"],"award-info":[{"award-number":["82172154"]}]},{"name":"Shanghai \u201cRising Stars of Medical Talents\u201d Youth Development Program","award":["SHWSRS [2024]_70"],"award-info":[{"award-number":["SHWSRS [2024]_70"]}]},{"name":"Shanghai \u201cRising Stars of Medical Talents\u201d Youth Development Program","award":["GWVI-11.2-XD37"],"award-info":[{"award-number":["GWVI-11.2-XD37"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Respir Crit Care Med"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Septic shock, the most severe manifestation of sepsis, is characterized by profound circulatory failure and carries the highest mortality risk among sepsis-related conditions. Current therapeutic strategies remain primarily supportive, emphasizing empirical antimicrobial therapy and advanced organ system support. The immunomodulatory properties of corticosteroids in sepsis pathophysiology have been extensively investigated since the 1970s, though current guidelines recommend corticosteroid therapy for sepsis patients, albeit with a weak evidence base. In this review, we explore the molecular underpinnings of corticosteroid activity in septic shock and clinical evidence from randomized controlled trials, with a special emphasis on the stabilization of hemodynamics and the impact on mortality outcomes. Furthermore, we analyze recent advances in pharmacodynamic understanding that may inform more targeted corticosteroid administration in septic shock.<\/jats:p>","DOI":"10.1055\/a-2694-4823","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T23:38:11Z","timestamp":1758065891000},"page":"086-097","source":"Crossref","is-referenced-by-count":1,"title":["Corticosteroid Treatment in Septic Shock"],"prefix":"10.1055","volume":"47","author":[{"given":"Jiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Shanghai Jiao Tong University School of Medicine, Ruijin Hospital, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Fudan University Shanghai Cancer Center, Shanghai, China"},{"name":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Shanghai Jiao Tong University School of Medicine, Ruijin Hospital, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Shanghai Jiao Tong University School of Medicine, Ruijin Hospital, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dechang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Shanghai Jiao Tong University School of Medicine, Ruijin Hospital, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Djillali","family":"Annane","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, APHP University Versailles Saint Quentin, University Paris Saclay, Raymond Poincar\u00e9 Hospital, Garches, France"},{"name":"SEPSIS Institute, Institut Hospitalo Universitaire IHU-3, Garches, France"},{"name":"Laboratory of Infection and Inflammation, U1173, School of Medicine, INSERM, University Versailles Saint Quentin, University Paris Saclay, Garches, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"issue":"08","key":"ref1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"M Singer","year":"2016","journal-title":"JAMA"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","article-title":"Assessment of global incidence and mortality of hospital-treated sepsis. 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