{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:31:40Z","timestamp":1783607500301,"version":"3.55.0"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nuklearmedizin"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to assess the diagnostic performance of 99mTc-sestamibi SPECT\/CT and 18F-choline PET\/CT in detecting hyperfunctioning parathyroid glands in patients undergoing surgery for primary hyperparathyroidism (PHPT).<\/jats:p><jats:p>A retrospective analysis was conducted on patients who underwent PHPT-related surgery between April 2019 and May 2022. The study focused on patients undergoing either 99mTc-sestamibi SPECT\/CT (81 patients) or 18F-choline PET\/CT (33 patients) scans before surgery to pinpoint hyperfunctioning parathyroid gland(s). In the majority of patients, 18F-choline PET\/CT was performed after negative or inconclusive findings on 99mTc-sestamibi SPECT\/CT. Pathohistological reports were utilized as the reference standard for evaluating the accuracy of the imaging findings.<\/jats:p><jats:p>The study encompassed 83 patients (70 females, 84.3 %) with an average age of 57.2 years (24\u201380 years). The pathohistological analysis identified a total of 98 glands. In a per-lesion analysis, the detection rate of 99mTc-sestamibi SPECT\/CT was 57 % (95 % CI 45.3\u201368.1), while the detection rate of 18F-choline PET\/CT was 90.3 % (95 % CI 74.3\u201398.0).<\/jats:p><jats:p>The results of our study showed the significant usefulness of 18F-choline PET\/CT in patients with negative or inconclusive results of 99mTc-sestamibi SPECT\/CT in accurately locating hyperfunctioning parathyroid glands in PHPT patients.<\/jats:p>","DOI":"10.1055\/a-2694-8426","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T23:00:24Z","timestamp":1758927624000},"page":"308-312","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic Performance of 99 mTc-Sestamibi SPECT\/CT and 18F-Choline PET\/CT in Locating Hyperfunctioning Parathyroid Glands in Patients with Primary Hyperparathyroidism"],"prefix":"10.1055","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4300-5154","authenticated-orcid":false,"given":"Ante","family":"Mandic","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Kraljevic","sequence":"additional","affiliation":[{"name":"University of Zagreb School of Medicine, Zagreb, Croatia"},{"name":"Department of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Skoric Polovina","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Zibar Tomsic","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Dusek","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia"},{"name":"University of Zagreb School of Medicine, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"Balasko","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirsala","family":"Solak","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3034-5598","authenticated-orcid":false,"given":"Darko","family":"Kastelan","sequence":"additional","affiliation":[{"name":"University of Zagreb School of Medicine, Zagreb, Croatia"},{"name":"Department of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.beem.2018.09.013","article-title":"Primary hyperparathyroidism","volume":"32","author":"BC Silva","year":"2018","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1007\/s00423-009-0533-5","article-title":"Positional statement of the European Society of Endocrine Surgeons (ESES) on modern techniques in pHPT 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