{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T23:42:10Z","timestamp":1763509330278,"version":"3.45.0"},"reference-count":45,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acne vulgaris, a prevalent inflammatory skin condition, impacts both\n                        appearance and quality of life, especially in adolescents. This study\n                        explores a novel treatment combining black seed oil, rosehip oil, and\n                        retinol within a nanoemulsion to improve therapeutic efficacy, drug\n                        delivery, and patient compliance while minimizing side effects.<\/jats:p>\n                  <jats:p>A nanoemulsion incorporating black seed oil, rosehip oil, and retinol was\n                        developed and characterized. Antimicrobial activity was evaluated via in\n                        vitro assays, while anti-inflammatory potential was assessed using standard\n                        models. HaCaT cell lines were used to determine cell viability. The\n                        formulation\u2019s performance was compared with commercially available Retino AC\n                        gel, focusing on stability, penetration, and overall effectiveness.<\/jats:p>\n                  <jats:p>The nanoemulsion showed strong antimicrobial effects against acne-related\n                        microbes, reduced inflammatory markers, and preserved high cell viability,\n                        confirming its biocompatibility. The combined action of black seed oil\u2019s\n                        anti-inflammatory and antioxidant properties, rosehip oil\u2019s sebum-regulating\n                        effects, and retinol\u2019s ability to promote cell turnover enhanced overall\n                        therapeutic outcomes. Compared to Retino AC gel, the nanoemulsion\n                        demonstrated superior efficacy, stability, and potential for better patient\n                        adherence.<\/jats:p>\n                  <jats:p>This study presents a synergistic, nature-based, and nano-enabled approach to\n                        treating acne and scars. The nanoemulsion offers a promising alternative to\n                        conventional therapies by improving effectiveness and safety. These results\n                        support further clinical development and highlight the potential of\n                        combining natural ingredients with advanced delivery systems for managing\n                        acne vulgaris.<\/jats:p>","DOI":"10.1055\/a-2698-0138","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T22:44:15Z","timestamp":1761173055000},"page":"367-378","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of a Retinol Nanoemulsion Gel Enriched with Black Seed and\n                    Rosehip Oils for Acne Management"],"prefix":"10.1055","volume":"75","author":[{"given":"Aishwarya","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Acharya and BM Reddy\n                    College of Pharmacy, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwin","family":"Ravichandran","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Acharya and BM Reddy\n                    College of Pharmacy, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sai Varshini","family":"Magham","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Vignan College of Pharmacy, Guntur,\n                    India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.12865\/CHSJ.46.02.02","article-title":"Myths, Perceptions and Practices in Acne: A Study on Adolescents and Young\n                    Adults","volume":"46","author":"A Yorulmaz","year":"2020","journal-title":"Curr Health Sci 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