{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:11:24Z","timestamp":1773324684497,"version":"3.50.1"},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Myasthenia gravis (MG) ist eine durch belastungsabh\u00e4ngige Muskelschw\u00e4che\ngekennzeichnete, chronische neuromuskul\u00e4re Autoimmunerkrankung, bei der\nsowohl genetische als auch Umweltfaktoren eine Rolle spielen. F\u00fcr einige\nAutoimmunerkrankungen konnte ein positiver Einfluss der mediterranen\nErn\u00e4hrung (MedE) nachgewiesen werden. Ob ein solcher Zusammenhang auch bei\nMG besteht, wurde bislang nicht untersucht.<\/jats:p>\n                  <jats:p>In einer monozentrischen, retrospektiven Kohortenstudie wurden\nanthropometrische Daten von 200 MG-Patienten erhoben. Zus\u00e4tzlich wurde die\nAdh\u00e4renz an eine MedE mithilfe des validierten Fragebogens \u201eMediterranean\nDiet Adherence Screener\u201c (MEDAS) bei einer Teilgruppe (n=43) erfasst. Die\nMG-Kohorte wurde in eine Therapie-refrakt\u00e4re (\u22653 Immunsuppressiva im\nVerlauf; n=23) und eine nicht-refrakt\u00e4re Gruppe (n=177) unterteilt. Die\nstatistische Auswertung erfolgte mittels SPSS.<\/jats:p>\n                  <jats:p>31,6\u202f% der Patienten waren adip\u00f6s, der mittlere BMI lag bei 27,2\u202fkg\/m\u00b2. Der\nmediane MEDAS-Score der Gesamtgruppe betrug 7,0 Punkte. In der\nTherapie-refrakt\u00e4ren Gruppe lag der Median bei 8,0 Punkten, in der\nnicht-refrakt\u00e4ren bei 6,0 Punkten. Ein signifikanter Unterschied zwischen\nden Gruppen konnte nicht festgestellt werden (p=0,69). Die ermittelten Werte\nzum MEDAS-Score lagen im Bereich bisheriger Vergleichsstudien zu anderen\nAutoimmunerkrankungen.<\/jats:p>\n                  <jats:p>MG-Patienten zeigten eine moderate Adh\u00e4renz an die MedE. Die Beobachtung\neines h\u00f6heren MEDAS-Scores in der refrakt\u00e4ren Gruppe bedarf weiterer\nUntersuchung. Die Ergebnisse unserer Studie konnten keine statistischen\nHinweise auf einen positiven Effekt der MedE auf den Verlauf der MG\nzeigen.<\/jats:p>","DOI":"10.1055\/a-2698-6039","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T23:00:41Z","timestamp":1759791641000},"page":"101-106","source":"Crossref","is-referenced-by-count":0,"title":["Adh\u00e4renz an die mediterrane Ern\u00e4hrung und anthropometrische Merkmale bei Patienten mit Myasthenia gravis: Eine retrospektive Kohortenstudie"],"prefix":"10.1055","volume":"94","author":[{"given":"Felix Maximilian Xaver","family":"Lorenz","sequence":"additional","affiliation":[{"name":"LMU Klinikum Friedrich-Baur-Institut, Munich,\nGermany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Seethaler","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Ern\u00e4hrungsmedizin, Universit\u00e4t Hohenheim,\nStuttgart, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2757-8131","authenticated-orcid":false,"given":"Benedikt","family":"Schoser","sequence":"additional","affiliation":[{"name":"Friedrich-Baur-Institut, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen,\nM\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3892\/mmr.2021.12151","article-title":"Clinical Genomic, phenotype and epigenetic insights into the pathology,\nautoimmunity and weight management of patients with Myasthenia Gravis\n(Review)","volume":"24","author":"R Golfinopoulou","year":"2021","journal-title":"Mol Med Rep"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1056\/NEJMoa1800389","article-title":"Primary Prevention of Cardiovascular Disease with a Mediterranean Diet\nSupplemented with Extra-Virgin Olive Oil or Nuts","volume":"378","author":"R Estruch","year":"2018","journal-title":"New England Journal of Medicine"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1136\/bmj.a1344","article-title":"Adherence to Mediterranean diet and health status: Meta-analysis","volume":"337","author":"F Sofi","year":"2008","journal-title":"BMJ."},{"key":"ref5","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/rheumatology\/keaa210","article-title":"Beneficial effect of Mediterranean diet on disease activity and cardiovascular\nrisk in systemic lupus erythematosus patients: A cross-sectional study","volume":"60","author":"G Pocovi-Gerardino","year":"2021","journal-title":"Rheumatology (United Kingdom)"},{"key":"ref6","first-page":"737","article-title":"et al. The effects of the Mediterranean diet on rheumatoid arthritis prevention and treatment: a systematic review of human prospective studies. Rheumatology International. Springer Verlagg; 2018: Vol.  38: p","author":"C Forsyth"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/art.41487","article-title":"Mediterranean Diet and Risk of Rheumatoid Arthritis: Findings From the French E3N-EPIC Cohort Study.","volume":"73","author":"Y Nguyen","year":"2021","journal-title":"Arthritis and Rheumatology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.3945\/jn.110.135566","article-title":"A Short screener is valid for assessing mediterranean diet adherence among older\nspanish men and women","volume":"141","author":"H Schr\u00f6der","year":"2011","journal-title":"Journal of Nutrition"},{"key":"ref13","first-page":"23","article-title":"et al. \u00dcbergewicht und Adipositas bei Erwachsenen in Deutschland. Journal of Health Monitoring [Internet]","author":"A Schienkiewitz","year":"2022"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.3945\/jn.112.164616","article-title":"Adherence to the mediterranean diet pattern has declined in Spanish adults","volume":"142","author":"L M Le\u00f3n-Mu\u00f1oz","year":"2012","journal-title":"Journal of Nutrition"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1177\/09612033231175289","article-title":"Beneficial effects associated to a healthy lifestyle in systemic lupus\nerythematosus: A cross-sectional study","volume":"32","author":"S Vordenb\u00e4umen","year":"2023","journal-title":"Lupus."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1080\/1028415X.2022.2034241","article-title":"Is Mediterranean diet associated with multiple sclerosis related symptoms and\nfatigue severity?","volume":"26","author":"Y Erta\u015f \u00d6zt\u00fcrk","year":"2023","journal-title":"Nutr Neurosci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"E207922","DOI":"10.1001\/jamanetworkopen.2020.7922","article-title":"Association of Low to Moderate Alcohol Drinking with Cognitive Functions from\nMiddle to Older Age among US Adults","volume":"3","author":"R Zhang","year":"2020","journal-title":"JAMA Netw Open"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"E236185","DOI":"10.1001\/jamanetworkopen.2023.6185","article-title":"Association between Daily Alcohol Intake and Risk of All-Cause Mortality: A\nSystematic Review and Meta-analyses","volume":"6","author":"J Zhao","year":"2023","journal-title":"JAMA Netw Open"},{"key":"ref24","first-page":"441","article-title":"Why Do Only Some Cohort Studies Find Health Bene\ufb01ts From Low-Volume Alcohol Use?\nA Systematic Review and Meta-Analysis of Study Characteristics That May Bias\nMortality Risk Estimates","volume":"85","author":"T Stockwell","year":"2024","journal-title":"J Stud Alcohol Drugs"},{"key":"ref25","first-page":"262","article-title":"Should we remove wine from the Mediterranean diet?: a narrative review. American Journal of Clinical Nutrition. Elsevier B.V. 2024; Vol.  119: p","author":"M A Mart\u00ednez-Gonz\u00e1lez"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.2174\/1570159X20666220830102628","article-title":"Ketogenic Diet: An Effective Treatment Approach for Neurodegenerative\nDiseases","volume":"20","author":"Y Tao","year":"2022","journal-title":"Curr Neuropharmacol"}],"container-title":["Fortschritte der Neurologie \u00b7 Psychiatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2698-6039.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:40:48Z","timestamp":1773272448000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2698-6039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,6]]},"references-count":16,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2026,3,11]]},"published-print":{"date-parts":[[2026,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2698-6039","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0720-4299","1439-3522"],"issn-type":[{"value":"0720-4299","type":"print"},{"value":"1439-3522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,6]]}}}