{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:13:57Z","timestamp":1758932037367,"version":"3.44.0"},"reference-count":8,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":261,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J Pediatr Surg Rep."],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Kaposiform hemangioendothelioma (KHE) is a rare, aggressive vascular tumor frequently complicated by Kasabach\u2013Merritt phenomenon (KMP), a life-threatening consumptive coagulopathy. Neonatal KHE-KMP management requires urgent intervention but is complicated by immunosuppression risks, especially in Bacillus Calmette\u2013Gu\u00e9rin (BCG)-vaccinated infants.<\/jats:p><jats:p>A full-term male neonate with prenatal right upper limb thickening presented postnatally with a violaceous, firm mass. Laboratory findings confirmed KMP. Due to recent BCG vaccination, sirolimus was initially withheld. First-line therapies failed, prompting sirolimus initiation on day 3, supplemented by fibrinogen transfusions.<\/jats:p><jats:p>Platelets normalized by day 13 (283\u2009\u00d7\u2009109\/L) with marked tumor regression. Transient fever\/diarrhea resolved with supportive care. At discharge (day 27), platelets stabilized (183\u2009\u00d7\u2009109\/L). Three-month follow-up showed sustained platelet recovery (268\u2013532\u2009\u00d7\u2009109\/L), near-complete tumor resolution, and age-appropriate development. Prophylactic trimethoprim-sulfamethoxazole prevented infections.<\/jats:p><jats:p>Sirolimus is a critical salvage therapy for refractory neonatal KHE-KMP, even in BCG-vaccinated infants. Timely initiation reverses life-threatening coagulopathy and achieves favorable outcomes, necessitating multidisciplinary monitoring to balance immunosuppression risks.<\/jats:p>","DOI":"10.1055\/a-2699-8104","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T23:13:37Z","timestamp":1758323617000},"page":"e55-e58","source":"Crossref","is-referenced-by-count":0,"title":["Kaposiform Hemangioendothelioma with Kasabach\u2013Merritt Phenomenon in a Neonate: A Case Report"],"prefix":"10.1055","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4758-1433","authenticated-orcid":false,"given":"Yuyang","family":"Zheng","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongjie","family":"Wu","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qilin","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyu","family":"Xiong","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialu","family":"Yun","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jpeds.2012.06.044","article-title":"Kaposiform hemangioendothelioma: atypical features and risks of Kasabach-Merritt phenomenon in 107 referrals","volume":"162","author":"S E Croteau","year":"2013","journal-title":"J Pediatr"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13023-020-1320-1","article-title":"Kaposiform hemangioendothelioma: current knowledge and future perspectives","volume":"15","author":"Y Ji","year":"2020","journal-title":"Orphanet J Rare Dis"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jpeds.2013.03.080","article-title":"Consensus-derived practice standards plan for 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