{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:38:48Z","timestamp":1760747928240,"version":"build-2065373602"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n               68Ga-Pentixafor positron emission tomography\/computed tomography has\n                    shown potential in primary aldosteronism subtyping, but analysis of its\n                    diagnostic accuracy based on contrast-enhanced computed tomography concordance\n                    and positron emission tomography\/computed tomography avidity patterns is\n                    lacking. The objective of this study was to evaluate the diagnostic accuracy of\n                        68Ga-Pentixafor positron emission tomography\/computed tomography\n                    for subtyping primary aldosteronism and to assess its performance based on\n                    concordance with contrast-enhanced computed tomography and positron emission\n                    tomography\/computed tomography avidity patterns. Clinical, biochemical,\n                    radiological, functional imaging, treatment, histopathological, and follow-up\n                    details of 30 patients with primary aldosteronism who underwent positron\n                    emission tomography\/computed tomography over 2 years at a tertiary center in\n                    India were retrospectively analyzed. Diagnostic accuracy of positron emission\n                    tomography\/computed tomography for primary aldosteronism subtyping was evaluated\n                    in the whole cohort and in subgroups based on contrast-enhanced computed\n                    tomography\u2013positron emission tomography\/computed tomography concordance and\n                    positron emission tomography\/computed tomography avidity patterns. Out of the 30\n                    patients, final subtype classification was achieved in 15 (9 unilateral and 6\n                    bilateral) based on surgical outcomes and\/or adrenal venous sampling. Positron\n                    emission tomography\/computed tomography correctly subtyped 14\/15 (93.3%)\n                    patients. Contrast-enhanced computed tomography and positron emission\n                    tomography\/computed tomography concordance was seen in 10 patients, and positron\n                    emission tomography\/computed tomography accuracy was 100% (10\/10) in this\n                    subgroup. Contrast-enhanced computed tomography and positron emission\n                    tomography\/computed tomography discordance (contrast-enhanced computed\n                    tomography bilateral and positron emission tomography\/computed tomography\n                    unilateral) was seen in five patients, and positron emission tomography\/computed\n                    tomography accuracy in this subgroup was 80% (4\/5). Positron emission\n                    tomography\/computed tomography avidity patterns in the 15 patients having final\n                    subtype classification were unilateral avid (n=10), bilateral avid\n                        (n=2), and bilateral nonavid (n=3). Diagnostic accuracy of\n                    positron emission tomography\/computed tomography was 90% (9\/10) in patients with\n                    unilateral avidity, and 100% in those with bilateral avidity or nonavidity.\n                    Preliminary analysis suggests that positron emission tomography\/computed\n                    tomography demonstrates higher accuracy in certain subgroups, potentially\n                    guiding the triage for adrenal venous sampling.<\/jats:p>","DOI":"10.1055\/a-2700-7598","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T23:06:44Z","timestamp":1757632004000},"page":"499-504","source":"Crossref","is-referenced-by-count":0,"title":["68Ga-Pentixafor Positron Emission Tomography\/Computed\n                    Tomography in Primary Aldosteronism: Preliminary Analysis on Contrast-Enhanced\n                    Computed Tomography Concordance and Positron Emission Tomography\/Computed\n                    Tomography Avidity Patterns"],"prefix":"10.1055","volume":"57","author":[{"given":"Anuj","family":"Ban","sequence":"additional","affiliation":[{"name":"Endocrinology, King Edward Memorial Hospital and Seth\n                    Gordhandas Sunderdas Medical College, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anurag Ranjan","family":"Lila","sequence":"additional","affiliation":[{"name":"Endocrinology, King Edward Memorial Hospital and Seth\n                    Gordhandas Sunderdas Medical College, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjiri","family":"Karlekar","sequence":"additional","affiliation":[{"name":"Endocrinology, King Edward Memorial Hospital and Seth\n                    Gordhandas Sunderdas Medical College, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit","family":"Barnabas","sequence":"additional","affiliation":[{"name":"Endocrinology, King Edward Memorial Hospital and Seth\n                    Gordhandas Sunderdas Medical College, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saba Samad","family":"Memon","sequence":"additional","affiliation":[{"name":"Endocrinology, King Edward Memorial Hospital and Seth\n                    Gordhandas Sunderdas Medical College, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijaya","family":"Sarathi","sequence":"additional","affiliation":[{"name":"Endocrinology, Vydehi Institute of Medical Sciences and\n                    Research Centre, Bengaluru, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, Homi Bhabha National Institute,\n                    Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krantikumar","family":"Rathod","sequence":"additional","affiliation":[{"name":"Radiology, King Edward Memorial Hospital and Seth\n                    Gordhandas Sunderdas Medical College, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer","family":"Rege","sequence":"additional","affiliation":[{"name":"General Surgery, King Edward Memorial Hospital and Seth\n                    Gordhandas Sunderdas Medical College, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Padma","family":"Badhe","sequence":"additional","affiliation":[{"name":"Radiology, King Edward Memorial Hospital and Seth\n                    Gordhandas Sunderdas Medical College, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. V.","family":"Harinarayan","sequence":"additional","affiliation":[{"name":"Endocrinology, Sakra World Hospital, Bengaluru,\n                    India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tushar","family":"Bandgar","sequence":"additional","affiliation":[{"name":"Endocrinology, King Edward Memorial Hospital and Seth\n                    Gordhandas Sunderdas Medical College, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1210\/endrev\/bnad026","article-title":"Treating primary aldosteronism-induced hypertension: novel approaches and future\n                    outlooks","volume":"45","author":"N Mullen","year":"2024","journal-title":"Endocr Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1210\/jc.2013-2805","article-title":"Long-term cardio- and cerebrovascular events in patients with primary\n                    aldosteronism","volume":"98","author":"P Mulatero","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/ajh\/hpac079","article-title":"Primary aldosteronism: state-of-the-art review","volume":"35","author":"A Vaidya","year":"2022","journal-title":"Am J Hypertens"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/ajh\/hpab189","article-title":"Morphologically normal-appearing adrenal glands as a prevalent source of\n                    aldosterone production in primary aldosteronism","volume":"35","author":"W W Parksook","year":"2022","journal-title":"Am J Hypertens"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1210\/jc.2018-02089","article-title":"Discordance between imaging and adrenal vein sampling in primary aldosteronism\n                    irrespective of interpretation criteria","volume":"104","author":"D Sam","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The management of primary aldosteronism: case detection, diagnosis, and\n                    treatment: an endocrine society clinical practice guideline","volume":"101","author":"J W Funder","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41591-022-02114-5","article-title":"[11C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically\n                    curable primary aldosteronism: a prospective, within-patient trial","volume":"29","author":"X Wu","year":"2023","journal-title":"Nat Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1161\/HYPERTENSIONAHA.117.09975","article-title":"Targeting CXCR4 (CXC chemokine receptor type 4) for molecular imaging of\n                    aldosterone-producing adenoma","volume":"71","author":"B Heinze","year":"2018","journal-title":"Hypertension"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1291775","DOI":"10.3389\/fendo.2024.1291775","article-title":"A comparison of the performance of 68Ga-Pentixafor PET\/CT versus\n                    adrenal vein sampling for subtype diagnosis in primary aldosteronism","volume":"15","author":"X Yin","year":"2024","journal-title":"Front Endocrinol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1210\/clinem\/dgad421","article-title":"The value of targeting CXCR4 with 68Ga-Pentixafor PET\/CT for\n                    subtyping primary aldosteronism","volume":"109","author":"Y Zheng","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e2583","DOI":"10.1210\/clinem\/dgae747","article-title":"Comparison of different diagnostic criteria of 68Ga-Pentixafor PET\/CT\n                    for the classification of primary aldosteronism","volume":"110","author":"X Zhang","year":"2025","journal-title":"J Clin Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s11307-024-01976-0","article-title":"68Ga-pentixafor PET\/CT is a supplementary method for primary\n                    aldosteronism subtyping compared with adrenal vein sampling","volume":"27","author":"T Yi","year":"2025","journal-title":"Mol Imaging Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"109156","DOI":"10.1016\/j.surg.2025.109156","article-title":"Evaluating the value of chemokine receptor type 4\u2013targeted PET imaging in\n                    diagnosing primary aldosteronism lateralization: a comparison with adrenal\n                    venous sampling","volume":"181","author":"N Lu","year":"2025","journal-title":"Surgery"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1533295","DOI":"10.3389\/fendo.2025.1533295","article-title":"The value of targeted CXCR4 18F-AlF-NOTA-pentixafor PET\/CT for subtyping primary\n                    aldosteronism","volume":"16","author":"Y Peng","year":"2025","journal-title":"Front Endocrinol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1530\/EC-19-0198","article-title":"Radiological differentiation of phaeochromocytoma from other malignant adrenal\n                    masses: importance of wash-in characteristics on multiphase CECT","volume":"8","author":"M Goroshi","year":"2019","journal-title":"Endocr Connect"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S2213-8587(16)30100-0","article-title":"Adrenal vein sampling versus CT scan to determine treatment in primary\n                    aldosteronism: an outcome-based randomised diagnostic trial","volume":"4","author":"T Dekkers","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s12020-024-04024-7","article-title":"Typing diagnostic value of 68Ga-pentixafor PET\/CT for patients with\n                    primary aldosteronism and unilateral nodules","volume":"87","author":"R Zuo","year":"2024","journal-title":"Endocrine"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4103\/ijem.ijem_177_22","article-title":"Adrenal venous sampling in primary aldosteronism: single-centre experience from\n                    Western India","volume":"27","author":"K Rathod","year":"2023","journal-title":"Indian J Endocrinol Metab"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"6476","DOI":"10.1038\/s41598-024-84096-7","article-title":"On the automated radiosynthesis of pharmaceutical grade\n                    [68Ga]Ga-Pentixafor, its pre-clinical evaluation, clinical\n                    application and radiation dosimetry aspects","volume":"15","author":"S R Menon","year":"2025","journal-title":"Sci Rep"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e2255609","DOI":"10.1001\/jamanetworkopen.2022.55609","article-title":"Accuracy of Gallium-68 Pentixafor positron emission tomography\u2013computed\n                    tomography for subtyping diagnosis of primary aldosteronism","volume":"6","author":"J Hu","year":"2023","journal-title":"JAMA Netw Open"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S2213-8587(17)30135-3","article-title":"Outcomes after adrenalectomy for unilateral primary aldosteronism: an\n                    international consensus on outcome measures and analysis of remission rates in\n                    an international cohort","volume":"5","author":"T A Williams","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41574-022-00730-2","article-title":"Primary aldosteronism \u2014 a multidimensional syndrome","volume":"18","author":"A F Turcu","year":"2022","journal-title":"Nat Rev Endocrinol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.jvir.2020.12.029","article-title":"\u201cDouble-Down\u201d adrenal vein sampling results in patients with apparent bilateral\n                    aldosterone suppression: utility of repeat sampling including super-selective\n                    sampling","volume":"32","author":"D M DePietro","year":"2021","journal-title":"J Vasc Interv Radiol"},{"key":"ref24","first-page":"4bvaa033","article-title":"Bilateral aldosterone suppression in patients with right unilateral primary\n                    aldosteronism and review of the literature","author":"SY T Tan","year":"2020","journal-title":"J Endocr Soc"},{"key":"ref25","first-page":"100384","article-title":"68Ga-pentixafor PET\/CT in guiding surgical management of primary\n                    aldosteronism","volume":"39","author":"G Zheng","year":"2025","journal-title":"J Clin Transl Endocrinol"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2700-7598.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T22:46:52Z","timestamp":1760741212000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2700-7598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":25,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2025,10,17]]},"published-print":{"date-parts":[[2025,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2700-7598","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"type":"print","value":"0018-5043"},{"type":"electronic","value":"1439-4286"}],"subject":[],"published-other":{"date-parts":[[2025,9,11]]},"published":{"date-parts":[[2025,9]]}}}