{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:22:06Z","timestamp":1771550526466,"version":"3.50.1"},"reference-count":85,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die Implantation eines transjugul\u00e4ren intrahepatischen portosystemischen Shunts (TIPS) hat sich als etabliertes interventionelles Verfahren zur Behandlung der dekompensierten Leberzirrhose und ihrer Komplikationen bew\u00e4hrt und wurde in den letzten Jahren kontinuierlich weiterentwickelt. Aktuelle Forschungsfragen konzentrieren sich darauf, die Patientenselektion und den Zeitpunkt der Intervention weiter zu optimieren. Eine TIPS-Anlage senkt effektiv den Druck in der Pfortader, wodurch die bakterielle Translokation und die systemische Entz\u00fcndung bei Zirrhosepatienten gemindert werden. Diese Reduktion der Entz\u00fcndung konnte mit einer Verringerung von Dekompensationsereignissen und einer Verbesserung der \u00dcberlebensraten in Verbindung gebracht werden. Dennoch bleiben Herausforderungen bei der pr\u00e4zisen Anpassung des portosystemischen Gradienten (PSG), um Symptome zu kontrollieren und Risiken wie hepatische Enzephalopathie oder kardiale Komplikationen zu minimieren.  Die Hauptindikationen f\u00fcr TIPS umfassen Varizenblutungen (insbesondere bei Hochrisikopatienten mit pr\u00e4emptivem TIPS innerhalb von 72 Stunden), rezidivierendem Aszites und das Budd-Chiari-Syndrom. Eine strenge Patientenselektion ist entscheidend, um den Nutzen zu maximieren und Risiken zu minimieren. Zusammenfassend stellt die TIPS-Anlage einen effektiven Ansatz zur Behandlung von Komplikationen der Leberzirrhose dar, welcher das \u00dcberleben und die Lebensqualit\u00e4t der Patienten verbessert.<\/jats:p>","DOI":"10.1055\/a-2700-9816","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T23:32:11Z","timestamp":1769470331000},"page":"37-49","source":"Crossref","is-referenced-by-count":0,"title":["Der Transjugul\u00e4re Intrahepatische Portosystemische Shunt (TIPS): aktuelle und innovative Konzepte"],"prefix":"10.1055","volume":"64","author":[{"given":"Dominik","family":"Bettinger","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin II, Universit\u00e4tsklinikum Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Sturm","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin II, Universit\u00e4tsklinikum Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlene","family":"Reincke","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin II, Universit\u00e4tsklinikum Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1417-4135","authenticated-orcid":false,"given":"Robert","family":"Thimme","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin II, Universit\u00e4tsklinikum Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schulthei\u00df","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin II, Universit\u00e4tsklinikum Freiburg, Freiburg, Germany"},{"name":"Berta-Ottenstein-Programm, Albert-Ludwigs-Universit\u00e4t Freiburg Medizinische Fakult\u00e4t, Freiburg, 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