{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T23:40:49Z","timestamp":1759362049183,"version":"build-2065373602"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":92,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP Rep"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fetal and neonatal alloimmune thrombocytopenia (FNAIT) occurs in the setting of maternal anti-human platelet antigen (anti-HPA) antibodies against paternally derived fetal platelet antigens. Recent studies have also demonstrated an association between chronic placental inflammation and FNAIT, specifically low-grade chronic histiocytic intervillositis (CHI). We present a neonate with profound thrombocytopenia after delivery with co-occurring CHI, whose platelet counts recovered rapidly with platelet transfusions, born to a primigravida mother with late-onset preeclampsia.<\/jats:p><jats:p>A male neonate was born at 40 weeks to a mother who had no known history of pregnancies, miscarriages, or transfusions. The mother developed severe preeclampsia during the induction of labor. Shortly after delivery, a physical exam of the infant showed inappropriate bruising on the heels of both feet, scattered petechiae on the hard palate, a hematoma on the left thigh after a vitamin K shot, and a bruise on the upper left abdomen. His platelet count was found to be 7,000. Platelet count rose to 94K by day 3 of life following transfusions. Placental pathology confirmed CHI. Maternal testing revealed anti-HPA-1 antibodies supporting FNAIT.<\/jats:p><jats:p>This case highlights a potential relationship between maternal alloimmune response and preeclampsia. It also highlights the importance of considering FNAIT as a diagnosis in a neonate presenting with thrombocytopenia regardless of maternal preeclampsia, and the importance of submitting the placenta for a pathology exam.<\/jats:p>","DOI":"10.1055\/a-2703-4068","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T23:08:11Z","timestamp":1759360091000},"page":"e163-e165","source":"Crossref","is-referenced-by-count":0,"title":["A Neonate with FNAIT Supported by Placental Chronic Histiocytic Intervillositis and Confounded by Maternal Preeclampsia: A Case Report"],"prefix":"10.1055","volume":"15","author":[{"given":"Hannah","family":"White","sequence":"additional","affiliation":[{"name":"Department of Medical, Larner College of Medicine at the University of Vermont, Burlington, Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelia","family":"Sybenga","sequence":"additional","affiliation":[{"name":"Department of Surgical\/Perinatal Pathology, University of Vermont Medical Center, Burlington, Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/bjh.15813","article-title":"Fetal and neonatal alloimmune thrombocytopenia: recommendations for evidence-based practice, an international approach","volume":"185","author":"L Lieberman","year":"2019","journal-title":"Br J Haematol"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/bjh.18173","article-title":"Anti-human platelet antigen-5b antibodies and fetal and neonatal alloimmune thrombocytopenia; incidental association or cause and effect?","volume":"198","author":"J Alm","year":"2022","journal-title":"Br J Haematol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.placenta.2021.07.291","article-title":"Platelet alloimmunization is associated with low grade chronic histiocytic intervillositis - a new link to a rare placental lesion?","volume":"112","author":"N H Nedberg","year":"2021","journal-title":"Placenta"},{"issue":"07","key":"ref4","first-page":"1241","article-title":"Pregnancy induced hypertension versus small weight for gestational age: cause of neonatal hematological disorders","volume":"64","author":"T O Bizerea","year":"2018","journal-title":"Clin Lab"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1309\/FK9D5WBA1UEPT5BB","article-title":"Quantitative standards for fetal and neonatal autopsy","volume":"126","author":"J G Archie","year":"2006","journal-title":"Am J Clin Pathol"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"e002490","DOI":"10.1136\/bmjopen-2012-002490","article-title":"Fetal intracranial haemorrhages caused by fetal and neonatal alloimmune thrombocytopenia: an observational cohort study of 43 cases from an international multicentre registry","volume":"3","author":"H Tiller","year":"2013","journal-title":"BMJ Open"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"102704","DOI":"10.1016\/j.transci.2019.102704","article-title":"Epidemiology and management of fetal and neonatal alloimmune thrombocytopenia","volume":"59","author":"T W de Vos","year":"2020","journal-title":"Transfus Apher Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"101038","DOI":"10.1016\/j.blre.2022.101038","article-title":"Fetal and neonatal alloimmune thrombocytopenia: current pathophysiological insights and perspectives for future diagnostics and treatment","volume":"59","author":"W Stam","year":"2023","journal-title":"Blood Rev"},{"issue":"02","key":"ref10","doi-asserted-by":"crossref","first-page":"e30131","DOI":"10.1002\/pbc.30131","article-title":"Thrombocytopenia and neonatal outcomes among extremely premature infants exposed to maternal hypertension","volume":"70","author":"J Delaney","year":"2023","journal-title":"Pediatr Blood Cancer"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12958-017-0245-6","article-title":"Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: a laboratory study using an in vitro model","volume":"15","author":"M Eksteen","year":"2017","journal-title":"Reprod Biol Endocrinol"}],"container-title":["American Journal of Perinatology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2703-4068.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T23:08:13Z","timestamp":1759360093000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2703-4068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":10,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2025,7,8]]},"published-print":{"date-parts":[[2025,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2703-4068","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2157-6998","2157-7005"],"issn-type":[{"value":"2157-6998","type":"print"},{"value":"2157-7005","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}