{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:24:30Z","timestamp":1762993470754,"version":"3.45.0"},"reference-count":41,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"abstract":"Zusammenfassung<\/jats:title>\n Zyklische Brechattacken unter chronischem Cannabis waren bis vor 25 Jahren\n nahezu unbekannt. Nach Legalisierung von Cannabis f\u00fcr den Freizeitgebrauch\n in Nordamerika und dem konsekutiven Anstieg des hochpotenten Cannabiskonsums\n nimmt die Pr\u00e4valenz von cannabis-bezogenem zyklischem Erbrechen in den\n dortigen Notaufnahmen besorgniserregend zu. In den ROME-IV Kriterien ist das\n cannabis-induzierte zyklische Erbrechen nun als Cannabinoid Hyperemesis\n Syndrom (CHS) definiert. Diese \u00dcbersichtsarbeit soll \u00fcber den aktuellen\n Wissensstand zu CHS informieren, da nach der Teillegalisierung von Cannabis\n zum Freizeitgebrauch auch in Deutschland mit einem Anstieg der CHS-F\u00e4lle zu\n rechnen ist.<\/jats:p>\n Scoping Review bez\u00fcglich der Diagnostik, Komplikationen,\n Behandlungsm\u00f6glichkeiten und Prognose des CHS.<\/jats:p>\n Cannabis-bezogene zyklische Brechattacken sind in der Notfallmedizin besser\n bekannt als in der Allgemein- und Suchtmedizin. Oft sind junge Erwachsene\n betroffen. Eine sichere Differenzierung zwischen CHS und dem nosologisch\n verwandten Cyclic Vomiting Syndrom (CVS) \u2013 bei dem 30% der Betroffenen\n ebenfalls chronisch Cannabis konsumieren \u2013 ist nur durch Feststellung einer\n Remission w\u00e4hrend einer mindestens 6-monatigen Abstinenz m\u00f6glich. Deshalb\n werden in den Notaufnahmen meistens Mischformen aus CVS und CHS gesehen\n (suspektes CHS), manchmal mit maskierten vital bedrohlichen Komorbidit\u00e4ten.\n Durch das schwere Erbrechen k\u00f6nnen ebenfalls gravierende Komplikationen\n entstehen. \u00dcbliche Antiemetika sind oft wirkungslos. Hei\u00dfes Duschen und\n Baden (diagnostisches Nebenkriterium in ROM-IV) sowie Haloperidol (bis 5 mg\n i.m.) k\u00f6nnen das schwere Erbrechen akut linderen. Auch eine Einreibung des\n Abdomens mit 0,075-0,1%er Capsaicin-Creme hilft, jedoch weniger schnell.\n Nach mehreren zyklischen CHS-Clustern, sinkt die individuelle Schwelle f\u00fcr\n deren Auftreten fortlaufend (Chronifizierung): Cannabis R\u00fcckf\u00e4lle f\u00fchren\n schon bei niedrigen Dosen zu st\u00e4rkeren und l\u00e4ngeren zyklischen CHS-Clustern\n als davor erlebt (Sensitisierung).<\/jats:p>\n Das CHS wird nosologisch in ROME-IV als spezielle Variante des CVS\n eingeordnet, aber es ist auch eine spezifische und meistens schwere\n cannabis-bezogene Erkrankung. Da eine Vollremission und Heilung\n (Vollremission mindestens 5 Jahre lang) nur durch eine anhaltende\n Cannabis-Abstinenz zu erreichen ist, liefert das suspekte CHS eine\n interdisziplin\u00e4re Herausforderung f\u00fcr verschiedene medizinische Disziplinen,\n der Konsiliar-\/ Liaisonpsychiatrie und der Suchthilfe.<\/jats:p>","DOI":"10.1055\/a-2704-5465","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:21:49Z","timestamp":1762993309000},"source":"Crossref","is-referenced-by-count":0,"title":["Das Cannabinoid Hyperemesis Syndrom: Ein Scoping\n Review"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2592-8337","authenticated-orcid":false,"given":"Udo","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Seelische Gesundheit, Evangelisches\n Krankenhaus Castrop-Rauxel, Castrop-Rauxel, Akademisches Lehrkrankenhaus der\n Universit\u00e4t Duisburg-Essen, Germany"},{"name":"LVR-Universit\u00e4tsklinik Essen, Klinik f\u00fcr Psychiatrie\n und Psychotherapie, Medizinische Fakult\u00e4t der Universit\u00e4t Duisburg-Essen, Essen,\n Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3238\/arztebl.2015.0271","article-title":"Risks associated with the non-medicinal use of cannabis","volume":"112","author":"E Hoch","year":"2015","journal-title":"Dtsch Arztebl Int"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.52778\/9783804743892","volume-title":"Hrsg. Cannabis. Ein Handbuch f\u00fcr Wissenschaft und Praxis. Auflage 1","author":"A Ziegler","year":"2022"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.2147\/SAR.S109576","article-title":"The cannabis withdrawal syndrome: current insights","volume":"8","author":"U Bonnet","year":"2017","journal-title":"Subst Abuse Rehabil"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1136\/gut.2003.036350","article-title":"Cannabinoid hyperemesis: cyclical hyperemesis in association with chronic\n cannabis abuse","volume":"53","author":"J H Allen","year":"2004","journal-title":"Gut"},{"key":"ref5","first-page":"466","volume-title":"Chapter 48: Cannabis Hyperemesis Syndrome. In:Handbook of Cannabis and Related\n Pathologies \u2013 Biology, Pharmacology, Diagnosis, and Treatment Reviews. 1st\n Edition. Editor: Victor Preedy","author":"U Bonnet","year":"2017"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1136\/gut.2003.036350","article-title":"A Comprehensive Review and Update on Cannabis Hyperemesis Syndrome","volume":"17","author":"P Loganathan","year":"2024","journal-title":"Pharmaceuticals (Basel)"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1053\/j.gastro.2024.01.040","article-title":"AGA Clinical Practice Update on Diagnosis and Management of Cannabinoid\n Hyperemesis Syndrome: Commentary","volume":"166","author":"A Rubio-Tapia","year":"2024","journal-title":"Gastroenterology"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1097\/WNF.0000000000000118","article-title":"An Overlooked Victim of Cannabis: Losing Several Years of Well-being and Inches\n of Jejunum on the Way to Unravel Her Hyperemesis Enigma","volume":"39","author":"U Bonnet","year":"2016","journal-title":"Clin Neuropharmacol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1159\/000524746","article-title":"A Case Report on Cannabinoid Hyperemesis Syndrome in Palliative Care: How Good\n Intentions Can Go Wrong","volume":"45","author":"H Senderovich","year":"2022","journal-title":"Oncol Res Treat"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1016\/j.mayocp.2014.06.013","article-title":"Synthetic cannabinoid leading to cannabinoid hyperemesis syndrome","volume":"89","author":"B L Bick","year":"2014","journal-title":"Mayo Clin Proc"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"e280","DOI":"10.1097\/PG9.0000000000000280","article-title":"A Rare Case of Cannabinoid Hyperemesis Syndrome Secondary to Cannabidiol for\n Refractory Epilepsy","volume":"4","author":"D T Katz","year":"2022","journal-title":"JPGN Rep"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e077908","DOI":"10.1136\/bmjopen-2023-077908","article-title":"Adverse outcomes of cannabis use in Canada, before and after legalisation of\n non-medical cannabis: cross-sectional analysis of the International Cannabis\n Policy Study","volume":"14","author":"A Marquette","year":"2024","journal-title":"BMJ Open"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1111\/fcp.12580","article-title":"Cannabinoid hyperemesis syndrome in two French emergency departments: a\n prospective cohort","volume":"35","author":"J Weiss","year":"2021","journal-title":"Fundam Clin Pharmacol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1055\/s-0031-1273372","article-title":"Cannabis-Hyperemesis-Syndrom [Cannabis hyperemesis syndrome]","volume":"80","author":"U Bonnet","year":"2012","journal-title":"Fortschr Neurol Psychiatr"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e14574","DOI":"10.1111\/nmo.14574","article-title":"The national prevalence of disorders of gut brain interaction in the United\n Kingdom in comparison to their worldwide prevalence: Results from the Rome\n foundation global epidemiology study","volume":"35","author":"H Jaafari","year":"2023","journal-title":"Neurogastroenterol Motil"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1007\/s00101-020-00850-2","article-title":"Cannabinoidhyperemesis als Differenzialdiagnose von \u00dcbelkeit und Erbrechen in\n der Notaufnahme [Cannabinoid hyperemesis as a differential diagnosis of nausea\n and vomiting in the emergency department]","volume":"70","author":"F Korn","year":"2021","journal-title":"Anaesthesist"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1007\/s00101-020-00850-2","article-title":"Cannabis Hyperemesis Syndrome Recovers Completely When the Use of Cannabis or\n Synthetic Cannabinoids Is Permanently Discontinued-Cyclic Vomiting Syndrome Does\n Not","volume":"167","author":"U Bonnet","year":"2024","journal-title":"Gastroenterology."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ajem.2021.01.004","article-title":"Topical capsaicin for the treatment of cannabinoid hyperemesis syndrome, a\n systematic review and meta-analysis","volume":"43","author":"A Pourmand","year":"2021","journal-title":"Am J Emerg Med"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"267","DOI":"10.2147\/OAEM.S473627","article-title":"Droperidol Plus Diphenhydramine for Symptom Improvement in Suspected Cannabinoid\n Hyperemesis Syndrome: A Prospective Cohort Study","volume":"16","author":"Q Chopra","year":"2024","journal-title":"Open Access Emerg Med"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1111\/acem.14062","article-title":"A Pilot Trial of Topical Capsaicin Cream for Treatment of Cannabinoid\n Hyperemesis Syndrome","volume":"27","author":"D J Dean","year":"2020","journal-title":"Acad Emerg Med"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.annemergmed.2020.08.021","article-title":"Intravenous Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome\n (HaVOC): A Randomized, Controlled Trial","volume":"77","author":"A J Ruberto","year":"2021","journal-title":"Ann Emerg Med"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.annemergmed.2023.03.005","article-title":"Cannabis Use Patterns and Whole-Blood Cannabinoid Profiles of Emergency\n Department Patients With Suspected Cannabinoid Hyperemesis Syndrome","volume":"82","author":"R S Wightman","year":"2023","journal-title":"Ann Emerg Med"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/acem.14773","article-title":"Cannabinoid hyperemesis syndrome: Clinical trajectories and patterns of use\n three months following a visit to the emergency department","volume":"31","author":"R S Wightman","year":"2024","journal-title":"Acad Emerg Med"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1111\/1556-4029.13819","article-title":"Cannabinoid Hyperemesis Syndrome: Reports of Fatal Cases","volume":"64","author":"M Nourbakhsh","year":"2019","journal-title":"J Forensic Sci"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1002\/jpn3.12317","article-title":"Cannabinoid hyperemesis syndrome co-occurring with superior mesenteric artery\n syndrome in adolescents","volume":"79","author":"A I Shanker","year":"2024","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.mayocp.2011.10.005","article-title":"Cannabinoid hyperemesis: a case series of 98 patients","volume":"87","author":"D A Simonetto","year":"2012","journal-title":"Mayo Clin Proc"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"e13604","DOI":"10.1111\/nmo.13604","article-title":"Guidelines on management of cyclic vomiting syndrome in adults by the American\n Neurogastroenterology and Motility Society and the Cyclic Vomiting Syndrome\n Association","volume":"31","author":"T Venkatesan","year":"2019","journal-title":"Neurogastroenterol Motil"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1097\/MPG.0000000000003220","article-title":"Urinary Cannabis Metabolite Concentrations in Cannabis Hyperemesis Syndrome","volume":"73","author":"J Cordova","year":"2021","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1159\/000525991","article-title":"Cannabis-Related Cyclic\/Episodic Hyperemesis Conditions: From Suspected to\n Definitive Cannabinoid Hyperemesis Syndrome","volume":"31","author":"U Bonnet","year":"2022","journal-title":"Med Princ Pract"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e14895","DOI":"10.1111\/nmo.14895","volume-title":"Cannabis use patterns and association with hyperemesis: A comprehensive\n review","author":"W L Hasler","year":"2025"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1055\/s-0033-1360065","article-title":"Keine Opiate gegen das Cannabis-Hyperemesis-Syndrom [No opiates against cannabis\n hyperemesis syndrome]","volume":"139","author":"U Bonnet","year":"2014","journal-title":"Dtsch Med Wochenschr"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1089\/can.2020.0083","article-title":"Cannabidiol Interferes with Establishment of \u03949-Tetrahydrocannabinol-Induced\n Nausea Through a 5-HT1A Mechanism","volume":"7","author":"M V DeVuono","year":"2022","journal-title":"Cannabis Cannabinoid Res"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.17226\/24625","volume-title":"The health effects of cannabis and cannabinoids: the current state of evidence\n and recommendations for research","author":"National Academies of Sciences, Engineering, and Medicine\n [NASEM]","year":"2017"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1465728","DOI":"10.3389\/ftox.2024.1465728","article-title":"Cannabinoid hyperemesis syndrome: genetic susceptibility to toxic exposure","volume":"6","author":"E B Russo","year":"2024","journal-title":"Front Toxicol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"e14886","DOI":"10.1111\/nmo.14886","article-title":"Central mechanisms of emesis: A role for GDF15","volume":"6","author":"T Borner","year":"2024","journal-title":"Neurogastroenterol Motil"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1038\/s41586-023-06921-9.","article-title":"GDF15 linked to maternal risk of nausea and vomiting during pregnancy","volume":"625","author":"M Fejzo","year":"2024","journal-title":"Nature."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/s41574-021-00529-7","article-title":"GF15: emerging biology and therapeutic applications for obesity and\n cardiometabolic disease","volume":"7","author":"D Wang","year":"2021","journal-title":"Nat Rev Endocrinol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"102070","DOI":"10.1016\/j.molmet.2024.102070.","article-title":"GDNF family receptor alpha-like (GFRAL) expression is restricted to the caudal\n brainstem","volume":"91","author":"C Hes","year":"2025","journal-title":"Mol Metab"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"111653","DOI":"10.1016\/j.cellsig.2025.111653","article-title":"The role of cannabinoid-mediated signaling pathways and mechanisms in brain\n disorders","volume":"128","author":"S Liu","year":"2025","journal-title":"Cell Signal"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"4285","DOI":"10.1096\/fj.15-272526","article-title":"The sympathetic nervous system is controlled by transient receptor potential\n vanilloid 1 in the regulation of body temperature","volume":"29","author":"K M Alawi","year":"2015","journal-title":"FASEB J"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.cgh.2018.05.020","article-title":"Functional Nausea and Vomiting Disorders in Adults","volume":"17","author":"I Aziz","year":"2019","journal-title":"Clin Gastroenterol Hepatol"}],"container-title":["Fortschritte der Neurologie \u00b7 Psychiatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2704-5465.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:21:50Z","timestamp":1762993310000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2704-5465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,12]]},"references-count":41,"URL":"https:\/\/doi.org\/10.1055\/a-2704-5465","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0720-4299","1439-3522"],"issn-type":[{"value":"0720-4299","type":"print"},{"value":"1439-3522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,12]]}}}