{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T23:08:47Z","timestamp":1776208127703,"version":"3.50.1"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg A Cent Eur Neurosurg"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The aim of this experimental study was to investigate the effects of autologous plasma used as an alternative to duraplasty.<\/jats:p>\n                  <jats:p>We operated 21 patients and 8 New Zealand Rabbits and performed duraplasty with autologous blood. First, heparin was added to autologous blood withdrawn from the patient\/rabbit. The sample was then centrifuged to obtain plasma. Protamine sulfate was added to the plasma. This mixture was then applied to the dural space and tumor cavity, resulting in fibrin formation within 2 to 3\u2009minutes. All 21 patients had magnetic resonance imaging (MRI) scans 1 month after surgery to show neodura formation. Three of our patients and all rabbits were operated at least a month later, and the biopsy was taken to show the neodura formation microsopically.<\/jats:p>\n                  <jats:p>In MRI scans, as well as in biopsies, we have detected the neodura formation. In rabbits that underwent experimental craniotomy and duratomy, neodura had formed as a weak, thin membrane that did not show continuity into the defect area after one month. In the control group, the distribution of collagen fibers appeared relatively normal in areas close to the intact dura. However, further from this area, the regular structure was disrupted, edematous areas had formed in the fibrous layers, and bone fragments were separated from the endosteal layer<\/jats:p>\n                  <jats:p>The hypothesis of this study was that plasma obtained from the patient's own arterial blood could serve as an alternative to traditional duraplasty materials. Plasma possesses many of the properties required for duraplasty material and can be a cost-effective, readily available option. Results demonstrate that autologous plasma does not induce significant histological changes and shows excellent biocompatibility with brain parenchyma. Therefore, autologous plasma can be considered a reliable and safe tissue sealant. It is easy to prepare and apply, remains stable in the operating room for 1 to 2\u2009hours, and can be adjusted in size and thickness according to the dural defect and tumor cavity dimensions.<\/jats:p>","DOI":"10.1055\/a-2705-2876","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T23:04:39Z","timestamp":1758323079000},"page":"169-175","source":"Crossref","is-referenced-by-count":1,"title":["Duraplasty with Autologous Blood: A Cost-Effective and Efficient Alternative to Medical Products"],"prefix":"10.1055","volume":"87","author":[{"given":"Ersin","family":"Haciyakupoglu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Heinrich-Braun-Klinikum Zwickau, Zwickau, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evren","family":"Y\u00fcvr\u00fck","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, VM Medical Park Maltepe, Maltepe, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dervis Mansuri","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Cukurova University, School of Medicine, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sait","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Medical Pathology, Cukurova University, School of Medicine, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebahattin","family":"Haciyakupo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Ac\u0131badem University School of Medicine, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1038\/s41598-020-80448-1","article-title":"Biomechanical characterization of human temporal muscle fascia in uniaxial tensile tests for graft purposes in duraplasty","volume":"11","author":"J Zwirner","year":"2021","journal-title":"Sci Rep"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"520","DOI":"10.3390\/medicina56100520","article-title":"What is considered a variation of biomechanical parameters in tensile tests of collagen-rich human soft tissues? 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An experimental study","volume":"126","author":"M Camlar","year":"2019","journal-title":"World Neurosurg"},{"key":"ref6","first-page":"17","article-title":"Endosal dural teparir: techniques and results","volume":"1","author":"B Schick","year":"1998","journal-title":"Saudi J Otorhinolaryngol Head Neck Surg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/b-006-149705","volume-title":"Hemostasin and Fleece- Bound Sealing in Neurosurgery","author":"C W Matulla","year":"2005"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3349\/ymj.1991.32.1.53","article-title":"Neurosurgical application of fibrin adhesive","volume":"32","author":"K C Lee","year":"1991","journal-title":"Yonsei Med J"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"508","DOI":"10.3171\/jns.1996.84.3.0508","article-title":"Ovine pericardium: a new material for duraplasty","volume":"84","author":"J Par\u00edzek","year":"1996","journal-title":"J Neurosurg"},{"issue":"02","key":"ref10","first-page":"90","article-title":"Technical nuances of autologous pericranium harvesting for dural closure in Chiari malformation surgery","volume":"76","author":"P Perrini","year":"2015","journal-title":"J Neurol Surg B Skull Base"},{"issue":"09","key":"ref11","first-page":"426","article-title":"Posterior cranial fossa surgery in 454 children. Comparison of results obtained in pre-CT and CT era and after various types of management of dura mater","volume":"14","author":"J Par\u00edzek","year":"1998","journal-title":"Childs Nerv Syst"},{"issue":"04","key":"ref12","first-page":"173","article-title":"Spinal dural closure without suture: Minimizing the risk of CSF leakage with a flat non-penetrating titanium U-clip","volume":"30","author":"F M Marin Laut","year":"2019","journal-title":"Neurocirugia (Astur Engl Ed)"},{"issue":"03","key":"ref13","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1590\/S0102-86502007000300004","article-title":"Biosynthetic cellulose induces the formation of a neoduramater following pre-natal correction of meningomyelocele in fetal sheep","volume":"22","author":"RdeC Sanchez e Oliveira","year":"2007","journal-title":"Acta Cir Bras"},{"issue":"03","key":"ref14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0090-3019(03)00380-X","article-title":"Usefulness of acellular dermal graft as a dural substitute in experimental model","volume":"61","author":"S Islam","year":"2004","journal-title":"Surg Neurol"},{"issue":"02","key":"ref15","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/SCS.0b013e31819b968f","article-title":"Duraplasty using autologous fascia lata reenforced by on-site pedicled muscle flap: technical note","volume":"20","author":"B Abuzayed","year":"2009","journal-title":"J Craniofac Surg"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"110677","DOI":"10.1016\/j.msec.2020.110677","article-title":"Design and evaluation of a biosynthesized cellulose drug releasing duraplasty","volume":"110","author":"T R Stumpf","year":"2020","journal-title":"Mater Sci Eng C"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"105033","DOI":"10.1016\/j.neuint.2021.105033","article-title":"Natural biomaterials in brain repair: a focus on collagen","volume":"146","author":"B Ucar","year":"2021","journal-title":"Neurochem Int"},{"issue":"01","key":"ref18","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s00701-010-0718-2","article-title":"Use of a collagen biomatrix (TissuDura) for dura repair: a long-term neuroradiological and neuropathological evaluation","volume":"153","author":"C Parlato","year":"2011","journal-title":"Acta Neurochir (Wien)"},{"issue":"03","key":"ref19","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/ajh.2830140304","article-title":"Interaction of protamine sulfate with thrombin","volume":"14","author":"R J Cobel-Geard","year":"1983","journal-title":"Am J Hematol"},{"issue":"02","key":"ref20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1055\/s-0038-1645207","article-title":"Neutralization of enoxaparine-induced bleeding by protamine sulfate","volume":"63","author":"J Van Ryn-McKenna","year":"1990","journal-title":"Thromb Haemost"},{"issue":"03","key":"ref21","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3171\/JNS-07\/09\/0642","article-title":"Application of a hydrogel sealant improves watertight closures of duraplasty onlay grafts in a canine craniotomy model","volume":"107","author":"M C Preul","year":"2007","journal-title":"J Neurosurg"},{"issue":"03","key":"ref23","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3171\/2018.3.PEDS17550","article-title":"Autologous cervical fascia duraplasty in 123 children and adults with Chiari malformation type I: surgical technique and complications","volume":"22","author":"B J Dlouhy","year":"2018","journal-title":"J Neurosurg Pediatr"},{"issue":"04","key":"ref25","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s00701-014-2021-0","article-title":"Autologous bone flap cranioplasty following decompressive craniectomy is combined with a high complication rate in pediatric traumatic brain injury patients","volume":"156","author":"K D Martin","year":"2014","journal-title":"Acta Neurochir (Wien)"},{"issue":"09","key":"ref26","first-page":"819","article-title":"A novel biomimetic composite substitute of PLL\/ gelatin nanofiber membrane for dura repairing, Neurological Research A. J Progress Neurosurg","volume":"39","author":"K Deng","year":"2017","journal-title":"Neurol Neurosci"},{"issue":"02","key":"ref27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2217\/nnm.10.132","article-title":"Dura mater regeneration with a novel synthetic, bilayered nanofibrous dural substitute: an experimental study","volume":"6","author":"K Kurpinski","year":"2011","journal-title":"Nanomedicine (Lond)"},{"issue":"04","key":"ref28","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1097\/SCS.0b013e318175f50b","article-title":"Dural repair with grafts using the gastrointestinal anastomosis stapler","volume":"19","author":"N D Banks","year":"2008","journal-title":"J Craniofac Surg"},{"key":"ref29","first-page":"634","volume-title":"Dorsaly exophytic brain stem gliomas","author":"P Narayan","year":"2005"}],"container-title":["Journal of Neurological Surgery Part A: Central European Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2705-2876.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:30:37Z","timestamp":1776205837000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2705-2876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,19]]},"references-count":27,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2026,4,14]]},"published-print":{"date-parts":[[2026,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2705-2876","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6315","2193-6323"],"issn-type":[{"value":"2193-6315","type":"print"},{"value":"2193-6323","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,9,19]]},"published":{"date-parts":[[2025,9,19]]}}}