{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T23:41:55Z","timestamp":1765496515577,"version":"3.48.0"},"reference-count":70,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Handchir Mikrochir Plast Chir"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Wunden an den Extremit\u00e4ten werden heute h\u00e4ufig zun\u00e4chst durch eine lokale\n                        Unterdrucktherapie (Vakuumtherapie) behandelt, bevor eine Knochen- und\n                        Weichteilrekonstruktion erfolgt. Angestrebte Effekte sind hierbei unter\n                        anderem eine aktive Wundkonditionierung, mit dem \u00fcbergeordneten Ziel des\n                        Erhalt der Extremit\u00e4t sowie der Wiederherstellung von Funktionalit\u00e4t und\n                        Lebensqualit\u00e4t. Die interdisziplin\u00e4re Zusammenarbeit bei der Behandlung\n                        oss\u00e4rer sowie vaskul\u00e4rer Pathologien, der Rekonstruktion und Rehabilitation\n                        wird als Ortho-Plastische Rekonstruktion bezeichnet.<\/jats:p>\n                  <jats:p>Die vorliegende Arbeit beschreibt zum einen wegweisende Meilensteine, die zur\n                        Entwicklung des orthoplastischen Konzeptes im Bereich der\n                        Extremit\u00e4ten-Rekonstruktion gef\u00fchrt haben. Zudem werden im folgenden\n                        grundlegende Prinzipien der modernen Versorgungsstrategien, einschlie\u00dflich\n                        der Wundbettkonditionierung mittels Vakuumtherapie, basierend auf der\n                        pertinenten Literatur, herausgearbeitet und anhand repr\u00e4sentativer Beispiele\n                        erl\u00e4utert.<\/jats:p>\n                  <jats:p>Eine \u00dcbersicht der Literatur zeigt, dass sich die orthoplastische Chirurgie\n                        in verschiedenen L\u00e4ndern zeitlich versetzt entwickelte. Erst durch moderne\n                        Techniken zur Skelettstabilisierung und Weichteilrekonstruktion fanden\n                        interdisziplin\u00e4re Konzepte, einschlie\u00dflich der topischen Vakuumtherapie,\n                        Eingang in den klinischen Alltag. Die Vorteile des ortho-plastischen\n                        Ansatzes liegen in einer schnelleren Stabilisierung, fr\u00fchzeitigen\n                        Weichteildeckung, verk\u00fcrzter Hospitalisierungsdauer, reduzierten\n                        Komplikationsraten und besseren funktionellen Langzeitergebnissen.<\/jats:p>\n                  <jats:p>Die lokale Unterdrucktherapie ist heute ein unverzichtbares Instrument im\n                        orthoplastischen Ansatz. Entscheidend ist die koordinierte Zusammenarbeit\n                        von plastisch-rekonstruktiver und unfallchirurgisch-orthop\u00e4discher Chirurgie\n                        zur zeitnahen Behandlung rekonstruktiver Extremit\u00e4tenverletzungen. An\n                        spezialisierten Zentren hat sich dieses Vorgehen bew\u00e4hrt, um den optimalen\n                        Rekonstruktionszeitpunkt zu bestimmen und die Ergebnisse zu verbessern. Die\n                        fr\u00fchere Annahme, eine Amputation sei oft vorteilhafter, wurde durch\n                        erfolgreiche orthoplastische Rekonstruktionen mit langfristigem\n                        Extremit\u00e4tenerhalt widerlegt. Ein Erhalt der Extremit\u00e4t wird heute, wenn\n                        immer m\u00f6glich, angestrebt.<\/jats:p>","DOI":"10.1055\/a-2706-0291","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T23:39:37Z","timestamp":1765496377000},"page":"455-464","source":"Crossref","is-referenced-by-count":0,"title":["Die Rolle von topischer Unterdrucktherapie\/Vakuumtherapie in der\n                    orthoplastischen Chirurgie \u2013 NPWT, NPWTi-d und ciNPT"],"prefix":"10.1055","volume":"57","author":[{"given":"Simon M","family":"Kratzer","sequence":"additional","affiliation":[{"name":"Plastisch- und Handchirurgische Klinik, Universit\u00e4tsklinikum Erlangen,\n                    Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"K\u00fcmmerl","sequence":"additional","affiliation":[{"name":"Plastisch- und Handchirurgische Klinik, Universit\u00e4tsklinikum Erlangen,\n                    Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Arkudas","sequence":"additional","affiliation":[{"name":"Plastisch- und Handchirurgische Klinik, Universit\u00e4tsklinikum Erlangen,\n                    Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymund E","family":"Horch","sequence":"additional","affiliation":[{"name":"Plastisch- und Handchirurgische Klinik, Universit\u00e4tsklinikum Erlangen,\n                    Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1080\/17434440.2020.1714434","article-title":"Topical negative-pressure wound therapy: emerging devices and techniques","volume":"17","author":"R E Horch","year":"2020","journal-title":"Expert Rev Med 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Steinberger","year":"2021","journal-title":"Clin Plast Surg"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00402-016-2600-z","article-title":"Bacterial reduction and shift with NPWT after surgical debridements: a\n                    retrospective cohort study","volume":"137","author":"T Jentzsch","year":"2017","journal-title":"Arch Orthop Trauma Surg"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.jccw.2014.02.001","article-title":"Negative Pressure Wound Therapy With Instillation (NPWTi) Better Reduces\n                    Post-debridement Bioburden in Chronically Infected Lower Extremity Wounds Than\n                    NPWT Alone","volume":"4","author":"S G Goss","year":"2012","journal-title":"J Am Coll Clin Wound Spec"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.1111\/iwj.14072","article-title":"Effects of negative pressure wound therapy with instillation and dwell time\n             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             With Instillation and Dwell Time","volume":"147","author":"Y F Diehm","year":"2021","journal-title":"Plast Reconstr Surg"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1111\/iwj.13428","article-title":"Limb salvage procedure in immunocompromised patients with therapy-resistant leg\n                    ulcers-The value of ultra-radical debridement and instillation negative-pressure\n                    wound therapy","volume":"17","author":"A Geierlehner","year":"2020","journal-title":"Int Wound J"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1111\/iwj.12958","article-title":"Negative pressure wound treatment with computer-controlled\n                    irrigation\/instillation decreases bacterial load in contaminated wounds and\n                    facilitates wound closure","volume":"15","author":"I Ludolph","year":"2018","journal-title":"Int Wound 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skin\n                    explants","volume":"10","author":"P L Phillips","year":"2013","journal-title":"Int Wound J"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1016\/j.athoracsur.2020.04.037","article-title":"Negative Pressure Wound Therapy Combined With Instillation for Sternoclavicular\n                    Joint Infection","volume":"110","author":"W Schreiner","year":"2020","journal-title":"Ann Thorac Surg"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/iwj.12452","article-title":"Clinical recommendations and practical guide for negative pressure wound therapy\n                    with instillation","volume":"13","author":"S Gupta","year":"2016","journal-title":"Int Wound J"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"61S","DOI":"10.1097\/PRS.0000000000007613","article-title":"Sacral and Ischial Pressure Ulcer Management With Negative-Pressure Wound\n                    Therapy With Instillation and Dwell","volume":"147","author":"O A Arowojolu","year":"2021","journal-title":"Plast Reconstr Surg"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"21","DOI":"10.12968\/jowc.2015.24.Sup4b.21","article-title":"Incisional negative pressure wound therapy for high-risk wounds","volume":"24","author":"R E Horch","year":"2015","journal-title":"J Wound Care"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3233\/ch-180450","article-title":"Changes of perfusion patterns of surgical wounds under application of closed\n                    incision negative pressure wound therapy in postbariatric patients1","volume":"72","author":"I Renno","year":"2019","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1111\/iwj.13683","article-title":"Response to the letter to the editor &apos;Novel imaging methods reveal\n                    positive impact of topical negative pressure application on tissue 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Surg"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/iwj.12612","article-title":"Closed incision negative pressure therapy: international multidisciplinary\n                    consensus recommendations","volume":"14","author":"C Willy","year":"2017","journal-title":"Int Wound J"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.jcot.2019.07.015","article-title":"Orthoplastic surgery: Need of the hour","volume":"10","author":"P Agarwal","year":"2019","journal-title":"J Clin Orthop Trauma"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1055\/s-0043-115730","article-title":"[Plastic reconstructive microsurgery in the elderly patient \u2013 Consensus\n                    statement of the German Speaking Working Group for Microsurgery of the\n                    Peripheral Nerves and Vessels]","volume":"50","author":"I Ludolph","year":"2018","journal-title":"Handchir Mikrochir Plast Chir"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1055\/s-0042-108806","article-title":"[Perioperative Management in Microsurgery \u2013 Consensus Statement of the German\n                    Speaking Society for Microsurgery of Peripheral Nerves and Vessels]","volume":"48","author":"T Kremer","year":"2016","journal-title":"Handchir Mikrochir Plast Chir"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1002\/micr.22405","article-title":"Combined free flaps with arteriovenous loops for reconstruction of extensive\n                    thoracic defects after sternal osteomyelitis","volume":"36","author":"C D Taeger","year":"2016","journal-title":"Microsurgery"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3390\/bioengineering9020075","article-title":"The History and Innovations of Blood Vessel Anastomosis","volume":"9","author":"W R Moritz","year":"2022","journal-title":"Bioengineering (Basel)"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1007\/s00776-005-0984-7","article-title":"Internal plate fixation of fractures: short history and recent developments","volume":"11","author":"H K Uhthoff","year":"2006","journal-title":"J Orthop Sci"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-2-8178-0391-3_1","volume-title":"History of Microsurgery","author":"Y Ikuta","year":"2013"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s00064-024-00870-w","article-title":"[Microsurgery]","volume":"36","author":"A Arkudas","year":"2024","journal-title":"Oper Orthop Traumatol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1007\/s00064-024-00868-4","article-title":"[Mechanical vascular anastomoses]","volume":"36","author":"P Pour Farid","year":"2024","journal-title":"Oper Orthop Traumatol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1111\/j.1742-481X.2007.00361.x","article-title":"Evidence-based medicine: vacuum-assisted closure in wound care management","volume":"4","author":"J E Hunter","year":"2007","journal-title":"Int Wound J"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3233\/CH-180536","article-title":"Effects of topical negative pressure therapy on perfusion and microcirculation\n                    of human skin","volume":"72","author":"S Muenchow","year":"2019","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref56","first-page":"488","article-title":"[Vacuum sealing as treatment of soft tissue damage in open fractures]","volume":"96","author":"W Fleischmann","year":"1993","journal-title":"Unfallchirurg"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/00000637-199706000-00002","article-title":"Vacuum-assisted closure: a new method for wound control and treatment: clinical\n                    experience","volume":"38","author":"L C Argenta","year":"1997","journal-title":"Ann Plast Surg"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13032-015-0023-4","article-title":"Effects of a formalized collaboration between plastic and orthopedic surgeons in\n                    severe extremity trauma patients; a retrospective study","volume":"9","author":"P Sommar","year":"2015","journal-title":"J Trauma Manag Outcomes"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1097\/00006534-198609000-00001","article-title":"Early microsurgical reconstruction of complex trauma of the extremities","volume":"78","author":"M Godina","year":"1986","journal-title":"Plast Reconstr Surg"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1002\/jor.25488","article-title":"From replantation to transplantation: The evolution of orthoplastic extremity\n                    reconstruction","volume":"41","author":"L S Levin","year":"2023","journal-title":"J Orthop Res"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1097\/01.Ta.0000028859.26504.7c","article-title":"The orthoplastic approach for management of the severely traumatized foot and\n                    ankle","volume":"54","author":"C Heitmann","year":"2003","journal-title":"J Trauma"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0030-5898(20)31815-0","article-title":"The reconstructive ladder. An orthoplastic approach","volume":"24","author":"L S Levin","year":"1993","journal-title":"Orthop Clin North Am"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1097\/00006534-199904050-00010","article-title":"The rectus abdominis free flap as an emergency procedure in extensive upper\n                    extremity soft-tissue defects","volume":"103","author":"R E Horch","year":"1999","journal-title":"Plast Reconstr Surg"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.3390\/jcm14051436","article-title":"Optimizing Outcomes in Mangled Lower Extremity Reconstruction: Insights from a\n                    Retrospective Study of 93 Patients and Their Functional Scores","volume":"14","author":"S D\u00fczg\u00fcn","year":"2025","journal-title":"J Clin Med"},{"key":"ref65","first-page":"1194","article-title":"The free \u201cemergency\u201d rectus abdominis flap transfer for coverage of complex hand\n                    injuries","volume":"115","author":"R E Horch","year":"1998","journal-title":"Langenbecks Arch Chir Suppl Kongressbd"},{"key":"ref66","first-page":"S2","article-title":"Negative Pressure Wound Therapy With Instillation: Review of Evidence and\n                    Recommendations","volume":"27","author":"P J Kim","year":"2015","journal-title":"Wounds"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/iwj.12664","article-title":"A solution for complex wounds: the evidence for negative pressure wound therapy\n                    with instillation","volume":"13","author":"E L Anghel","year":"2016","journal-title":"Int Wound J"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"108920","DOI":"10.1016\/j.surg.2024.10.011","article-title":"The efficacy of negative-pressure wound therapy (NPWT) in the prevention of\n                    surgical site occurrences in open abdominal surgery: A randomized clinical\n                    trial","volume":"178","author":"M Moreno Gij\u00f3n","year":"2025","journal-title":"Surgery"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1016\/j.jvs.2017.06.084","article-title":"Randomized clinical trial of negative pressure wound therapy for high-risk groin\n                    wounds in lower extremity revascularization","volume":"66","author":"K Lee","year":"2017","journal-title":"J Vasc Surg"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1016\/j.cmi.2019.06.005","article-title":"Negative pressure wound therapy for surgical site infections: a systematic\n                    review and meta-analysis of randomized controlled trials","volume":"25","author":"H Z Li","year":"2019","journal-title":"Clin Microbiol Infect"}],"container-title":["Handchirurgie \u00b7 Mikrochirurgie \u00b7 Plastische Chirurgie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2706-0291.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T23:39:56Z","timestamp":1765496396000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2706-0291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":70,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2025,12,11]]},"published-print":{"date-parts":[[2025,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2706-0291","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0722-1819","1439-3980"],"issn-type":[{"value":"0722-1819","type":"print"},{"value":"1439-3980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]}}}