{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:58:54Z","timestamp":1780419534496,"version":"3.54.1"},"reference-count":102,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diabetic neuropathy, a debilitating complication of diabetes, arises from chronic\n                    hyperglycemia-induced inflammation and oxidative stress, leading to progressive\n                    nerve damage. Current therapeutic strategies often focus on symptomatic relief\n                    rather than addressing the underlying pathophysiology. Emerging evidence\n                    highlights the therapeutic potential of phytobioactives with robust\n                    anti-inflammatory and antioxidant properties as promising alternatives for\n                    diabetic neuropathy management. Phytobioactives such as flavonoids, polyphenols,\n                    alkaloids, and terpenoids demonstrate significant potential by mitigating\n                    oxidative stress, inhibiting pro-inflammatory cytokines, and promoting\n                    neuroprotection. Furthermore, combination approaches utilizing the synergistic\n                    effects of these phytobioactives have shown enhanced efficacy in preclinical\n                    models, targeting multiple pathways involved in the progression of diabetic\n                    neuropathy. However, clinical translation is hindered by challenges including\n                    low bioavailability, chemical instability, and suboptimal dosage. This review\n                    explores the mechanistic roles, preclinical evidence, and clinical challenges of\n                    phytobioactives in diabetic neuropathy therapy, emphasizing the need for\n                    advanced formulation strategies and well-designed clinical trials to optimize\n                    their therapeutic potential. Leveraging these phytobioactives could pave the way\n                    for more effective and holistic diabetic neuropathy treatments.<\/jats:p>","DOI":"10.1055\/a-2706-7255","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T22:41:27Z","timestamp":1760740887000},"page":"462-472","source":"Crossref","is-referenced-by-count":1,"title":["An Insight into the Therapeutic Potential of Phytobioactives for\n                    Diabetic Neuropathy"],"prefix":"10.1055","volume":"133","author":[{"given":"Asif","family":"Eqbal","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Integral University, Lucknow,\n                    India"},{"name":"Hygia Institute of Pharmacy, Lucknow,\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam","family":"Kushwaha","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Integral University, Lucknow,\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Hygia Institute of Pharmaceuticals Education and\n                    Research, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashmun","family":"Nisha","sequence":"additional","affiliation":[{"name":"Hygia Institute of Pharmacy, Lucknow,\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabiya","family":"Ahsan","sequence":"additional","affiliation":[{"name":"Hygia Institute of Pharmacy, Lucknow,\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md","family":"Asif","sequence":"additional","affiliation":[{"name":"Hygia Institute of Pharmacy, Lucknow,\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2337\/dc16-2042","article-title":"Diabetic neuropathy: a position statement by the American Diabetes\n                    Association","volume":"40","author":"R Pop-Busui","year":"2016","journal-title":"Diabetes Care"},{"key":"ref2","volume-title":"The papyrus Ebers","author":"B Ebbell","year":"1937"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-319-93521-8_1","volume-title":"A Historical Overview of Diabetic Nephropathy","author":"G Eknoyan","year":"2019"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"671257","DOI":"10.3389\/fendo.2021.671257","article-title":"Advances in screening, early diagnosis and accurate staging of diabetic\n                    neuropathy","volume":"12","author":"J 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