{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T23:09:48Z","timestamp":1774998588391,"version":"3.50.1"},"reference-count":110,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nyctanthes arbor-tristis, commonly known as night-flowering jasmine or parijat, is a plant of notable importance in traditional medicine and cultural practices. It is characterized by its nocturnally blooming, fragrant flowers. Traditional medicinal systems have extensively utilized this species for its therapeutic properties, which modern clinical research has supported. This plant, renowned for its therapeutic potential, has been integral to folk medicine for addressing antibilious conditions, gynecological disorders, and liver protection, highlighting its historical significance.<\/jats:p>\n                  <jats:p>This review aims to conduct a comprehensive ethnopharmacological evaluation of Nyctanthes arbor-tristis, with a focus on its chemical composition and pharmacological properties. It seeks to explore its therapeutic potential while identifying gaps requiring further scientific investigation.<\/jats:p>\n                  <jats:p>The review draws on data from credible sources such as PubMed, Google Scholar, and related literature published from 2013 to 2024 using keywords such as Nyctanthes arbor-tristis, night-flowering jasmine, sorrow plant, harsingar, harasingaar, pavazha mattigai, paarijaata, parijathak, and parijatha.<\/jats:p>\n                  <jats:p>The literature reveals that Nyctanthes arbor-tristis contains several phytoconstituents, including steroids, terpenes, flavonoids, phenols, iridoid glycosides, and alkaloids. These compounds, distributed across its leaves, seeds, flowers, and stem bark, exhibit distinct pharmacological activities. Reported effects include anti-inflammatory, anti-oxidant, analgesic, anti-diabetic, anti-arthritic, cytotoxic, anti-microbial, anti-malarial, anthelmintic, larvicidal, bronchodilatory, hepatoprotective, immunomodulatory, neuroprotective, and wound healing activities. This plant is also widely recognized for its traditional uses and is used by various countries and communities for the treatment of sciatica, arthritis, fever, liver disorders, and parasitic infections. Additionally, various parts, such as leaves, roots, bark, and seeds, are used across cultures for their dermatological effects, sedative properties, and antispasmodic actions. Despite its potential, the existing\n          pharmacological and phytochemical data remain insufficient, necessitating further research to understand its mechanisms of action and therapeutic applications.<\/jats:p>\n                  <jats:p>With its diverse bioactive compounds, Nyctanthes arbor-tristis shows promise as a source of natural therapeutics. However, comprehensive studies are essential to validate its ethnomedicinal applications and understand its mechanisms of action. Such efforts could facilitate the development of effective, low-side-effect natural therapeutic products, addressing a growing demand for alternative medicines in contemporary healthcare.<\/jats:p>","DOI":"10.1055\/a-2706-7358","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:37:01Z","timestamp":1762821421000},"page":"440-464","source":"Crossref","is-referenced-by-count":0,"title":["Nyctanthes arbor-tristis: A Multifaceted Medicinal Plant in Traditional and Contemporary Medicine"],"prefix":"10.1055","volume":"92","author":[{"given":"Ayan","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"M.\u200aM. College of Pharmacy, Maharishi Markandeshwar (Deemed to be) University, Mullana, Ambala, HR, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh Kumar","family":"Mehta","sequence":"additional","affiliation":[{"name":"M.\u200aM. College of Pharmacy, Maharishi Markandeshwar (Deemed to be) University, Mullana, Ambala, HR, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"M.\u200aM. College of Pharmacy, Maharishi Markandeshwar (Deemed to be) University, Mullana, Ambala, HR, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2535-2729","authenticated-orcid":false,"given":"Rina","family":"Das","sequence":"additional","affiliation":[{"name":"M.\u200aM. College of Pharmacy, Maharishi Markandeshwar (Deemed to be) University, Mullana, Ambala, HR, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e0011","DOI":"10.1097\/pp9.0000000000000011","article-title":"Traditional knowledge-based medicine: A review of history, principles, and relevance in the present context of P4 systems medicine","volume":"2","author":"N Lemonnier","year":"2017","journal-title":"Prog Prev Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.jaim.2019.09.003","article-title":"Controversial identities of medicinal plants in classical literature of Ayurveda","volume":"11","author":"V Thomas","year":"2020","journal-title":"J Ayurveda Integr Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.20897\/ejeph.201703","article-title":"Traditional health care systems and herbal medicines","volume":"1","author":"C P Kala","year":"2017","journal-title":"Eur J Environ Public Health"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2500","DOI":"10.1002\/fsn3.3308","article-title":"Phytobioactive compounds as therapeutic agents for human diseases: A review","volume":"11","author":"M Riaz","year":"2023","journal-title":"Food Sci Nutr"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1177\/097206340500700208","article-title":"Medicinal plants and primary health care: The role of gender","volume":"7","author":"R Singhal","year":"2005","journal-title":"J Health Manag"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/B978-0-12-814619-4.00001-X","article-title":"Herbal medicine: Current trends and future prospects","volume":"1","author":"M S Khan","year":"2019","journal-title":"NLPM"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"95","DOI":"10.7324\/JABB.2020.80116","article-title":"Nyctanthes arbor-tristis: Comprehensive review on its pharmacological, antioxidant, and anticancer activities","volume":"8","author":"S Parekh","year":"2020","journal-title":"J Appl Biol Biotechnol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.47760\/ijpsm.2024.v09i07.001","article-title":"Phytochemicals and pharmacological properties of Nyctanthes arbor-tristis: A review","volume":"9","author":"P Thapa","year":"2024","journal-title":"Int J Pharm Sci Med"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"11","DOI":"10.47760\/ijpsm.2023.v08i12.002","article-title":"From ancient remedies to modern marvels: Unveiling the medicinal secrets of Nyctanthes Arbortristis and Piper Betle Linn. leaves-a comprehensive review","volume":"8","author":"P Kushwah","year":"2023","journal-title":"Int J Pharma Sci Med"},{"key":"ref11","first-page":"180","article-title":"Nyctanthes arbor-tristis: An important vulnerable medicinal plant","volume":"1","author":"D Upadhyay","year":"2018","journal-title":"Int J Adv Sci Res Management"},{"key":"ref12","first-page":"344","article-title":"Phcog rev.: Review article phytoconstituents and therapeutic potential of Nyctanthes arbortristis Linn","volume":"1","author":"D Sasmal","year":"2007","journal-title":"Pharmacogn Rev"},{"key":"ref13","first-page":"21","article-title":"Review of Nyctanthes Arbortristis as a medicinal plant","volume":"2022","author":"D M Kulkarni","year":"2022","journal-title":"Ind J Res Methods Pharm Sci"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1556\/ABot.53.2011.3-4.2","article-title":"Pharmacognostic studies on the leaf of Nyctanthes arbor-tristis","volume":"53","author":"I Biswas","year":"2011","journal-title":"Acta Bot Hung"},{"key":"ref15","first-page":"91","article-title":"Nyctanthes arbortristis: A pharmacognostic review","volume":"1","author":"A V Bhosale","year":"2009","journal-title":"Res J Pharm Phyto"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s40011-020-01213-y","article-title":"Nyctanthes arbor-tristis L.: \u201cAn unexplored plant of enormous possibilities for economic revenue\u201d","volume":"91","author":"L Sharma","year":"2021","journal-title":"PNAS,IS-B:BS"},{"key":"ref17","first-page":"9","article-title":"The wonder of Ayurvedic medicine-Nyctanthes arbortristis","volume":"4","author":"P K Jain","year":"2016","journal-title":"Int J Herb Med"},{"key":"ref18","first-page":"427","article-title":"Nyctanthes arbor-tristis Linn. 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