{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T15:16:18Z","timestamp":1769786178067,"version":"3.49.0"},"reference-count":44,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"name":"National Natural Science Foundation Incubation Project of the Second Affiliated Hospital of Nanchang University","award":["2022YNFY12039"],"award-info":[{"award-number":["2022YNFY12039"]}]},{"name":"Jiangxi Province Key Laboratory of Precision Cell Therapy","award":["2024SSY06241"],"award-info":[{"award-number":["2024SSY06241"]}]},{"name":"Science and Technology Plan Projects of Jiangxi Administration of Traditional Chinese Medicine","award":["2023A0362"],"award-info":[{"award-number":["2023A0362"]}]},{"name":"Science and Technology Plan Project of Jiangxi Provincial Health Commission","award":["202310536"],"award-info":[{"award-number":["202310536"]}]},{"name":"General Program of Jiangxi Provincial Natural Science Foundation","award":["20224BAB206105"],"award-info":[{"award-number":["20224BAB206105"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sinopodophyllum hexandrum (\u201cTaoerqi\u201d) is a traditional Tibetan medicine used for treating inflammation and arthralgia, but its therapeutic basis against rheumatoid arthritis (RA) remains unclear. This study aimed to identify its active anti-RA fraction, analyse its chemical composition, and explore its mechanisms of action. Using a CFA-induced arthritis rat model, the dichloromethane fraction of S. hexandrum (SHD) was evaluated for anti-RA activity. UHPLC-Q-TOF-MS\/MS identified 57 compounds, mainly prenylated flavonoids and arylnaphthalene lignans. Network pharmacology predicted their targets, and in vitro assays on TNF-\u03b1-induced fibroblast-like synoviocytes confirmed the anti-RA effects of 15 isolates. Enzyme inhibition, molecular docking, surface plasmon resonance, and Western blot validated their interactions with TNF-\u03b1 and JAK1. Oral administration of SHD significantly reduced paw swelling and neutrophil infiltration in RA rats. These\n          findings suggest that prenylated flavonoids and arylnaphthalene lignans are key active components exerting anti-RA effects, respectively, via TNF-\u03b1 and JAK1 inhibition, highlighting their potential for further drug development.<\/jats:p>","DOI":"10.1055\/a-2706-8264","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T22:39:58Z","timestamp":1760999998000},"page":"123-138","source":"Crossref","is-referenced-by-count":0,"title":["Active Components and Multi-target Mechanism of Tibetan Sinopodophyllum hexandrum Medicine Against Rheumatoid Arthritis Using a CFA-induced Arthritis Rat Model"],"prefix":"10.1055","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8553-3882","authenticated-orcid":false,"given":"Bao-Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Affiliated Hospital of Nanchang University, Nanchang, China"},{"name":"Jiangxi Province Key Laboratory of Precision Cell Therapy, The Second Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Nanchang Hongdu Hospital of Traditional Chinese Medicine, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Gen","family":"Ao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Peng","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Ran","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Qiang","family":"Qian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Ke","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Fang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Long","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"J S Smolen","year":"2016","journal-title":"The Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2478\/rir-2021-0002","article-title":"2018 Chinese guidelines for the diagnosis and treatment of rheumatoid arthritis","volume":"2","author":"X Tian","year":"2021","journal-title":"Rheumatol Immunol Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","article-title":"The pathogenesis of rheumatoid arthritis","volume":"365","author":"L B McInnes","year":"2011","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1159\/000493390","article-title":"Rheumatoid arthritis: 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