{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:44:39Z","timestamp":1789908279644,"version":"4.0.1"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Achalasia, a rare esophageal motility disorder, is managed with medications, botulinum toxin, pneumatic dilation (PD), or surgery. In resource-limited settings like Pakistan, PD is preferred first-line non-surgical treatment due to its accessibility and cost-effectiveness so we aim to assess remission rates and clinical outcomes of PD.<\/jats:p>\n                  <jats:p>Between 2015 and 2024, 213 achalasia patients were diagnosed via HRM at Center for Liver &amp; Digestive Diseases, Holy Family Hospital, Rawalpindi. 191 patients opted for PD and completed follow-up interviews using Eckardt score and ASQ questionnaire. Data analysis was performed using SPSS.<\/jats:p>\n                  <jats:p>Among 191 patients (107 males, 84 females), 53% underwent one, 30% two, and 17% three PD session. Success rates were 58% for one, 78% for two, and 87.5% for three sessions, with no severe complications. The cumulative re-dilation rate was 20%, with a 76% success rate for repeat dilations. Multiple PDs significantly outperformed single PDs(p=0.01), reducing mean Eckardt score from 6.7 to 1.9. QoL improved with successful dilations but not in failed cases.<\/jats:p>\n                  <jats:p>PD provides sustained symptom relief for up to five years, with repeat sessions enhancing long-term success, reinforcing PD as an effective, durable, and accessible treatment option for achalasia in low-resource settings for evidence-based clinical decision-making.<\/jats:p>","DOI":"10.1055\/a-2707-1799","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T23:46:06Z","timestamp":1768261566000},"page":"147-156","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating Long-Term Functional and Symptomatic Outcomes of Pneumatic Dilatation in Achalasia: An Experience from Pakistan"],"prefix":"10.1055","volume":"64","author":[{"given":"Sameen","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanza","family":"Zahid","sequence":"additional","affiliation":[{"name":"Rawalpindi Medical University, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Rawalpindi Medical University, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayyab Saeed","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Center for Liver and Digestive Diseases, Holy Family Hospital, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Mushtaq","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China"},{"name":"Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Wahid","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amjad","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan"},{"name":"Department of Pharmacy, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China"},{"name":"Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000547354","article-title":"PATHOPHYSIOLOGY OF ACHALASIA","author":"A 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Pratap","year":"2011","journal-title":"J Neurogastroenterol Motil"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.giec.2014.07.001","article-title":"The Chicago classification of motility disorders: an update","volume":"24","author":"S Roman","year":"2014","journal-title":"Gastrointestinal Endoscopy Clinics"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"485","DOI":"10.5056\/jnm.2013.19.4.485","article-title":"Clinical characteristics and treatment outcomes of 3 subtypes of achalasia according to the chicago classification in a tertiary institute in Korea","volume":"19","author":"JY Lee","year":"2013","journal-title":"J Neurogastroenterol Motil"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-019-1104-z","article-title":"Durability of pneumatic dilation monotherapy in treatment-naive Achalasia patients","volume":"19","author":"AT Javed","year":"2019","journal-title":"BMC Gastroenterol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1136\/gutjnl-2015-310602","article-title":"Long-term results of the European achalasia trial: a multicentre randomised controlled trial comparing pneumatic dilation versus laparoscopic Heller myotomy","volume":"65","author":"A Moonen","year":"2016","journal-title":"Gut"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s10620-019-05784-3","article-title":"Updated systematic review of achalasia, with a focus on POEM therapy","volume":"65","author":"MS Cappell","year":"2020","journal-title":"Dig Dis Sci"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e70041","DOI":"10.1002\/jgh3.70041","article-title":"Optimizing achalasia diagnosis in the era of high\u2010resolution manometry: A Pakistani perspective","volume":"9","author":"S Abbas","year":"2025","journal-title":"JGH 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Lopushinsky","year":"2006","journal-title":"JAMA"}],"container-title":["Zeitschrift f\u00fcr 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