{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:15:24Z","timestamp":1788218124225,"version":"build-2803163510"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aktuelle Urol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die multiparametrische MRT-Ultraschall-Fusionsbiopsie erlaubt die gezielte Probenentnahme aus verd\u00e4chtigen Prostatal\u00e4sionen auf Basis der PI-RADS-Klassifikation. Ziel dieser retrospektiven Studie war die Evaluation der diagnostischen Leistungsf\u00e4higkeit der transperinealen multiparametrischen MRT-Fusionsbiopsie, stratifiziert nach dem PI-RADS-Score der L\u00e4sionen.<\/jats:p>\n                  <jats:p>476 Patienten, die zwischen Januar 2022 und Dezember 2024 sowohl eine systematische 12-fach-Stanzbiopsie als auch multiparametrische MRT-gest\u00fctzte Fusionsbiopsien aus mindestens einer Region of Interest erhielten, wurden eingeschlossen. Der prim\u00e4re Endpunkt dieser Studie war der Nachweis eines klinisch signifikanten Prostatakarzinoms (Gleason \u22653+4=7a). Die L\u00e4sionen wurden hierbei nach dem PI-RADS-Score klassifiziert. Die Histologie der einzelnen L\u00e4sionen, erfasst durch die multiparametrische MRT-Fusionsbiopsie, wurde separat analysiert. Statistische Auswertungen wurden mittels binomialer logistischer Regression durchgef\u00fchrt; p&lt;0,05 galt als signifikant.<\/jats:p>\n                  <jats:p>Die gezielte multiparametrische MRT-Fusionsbiopsie, basierend auf dem PI-RADS-Score, war ein signifikanter Pr\u00e4diktor f\u00fcr das Vorliegen eines klinisch relevanten Karzinoms (p&lt;0,001). Die Number Needed to Test f\u00fcr die kombinierte Biopsie (systematische + multiparametrische MRT-Fusion) betrug 2,4; f\u00fcr die systematische Biopsie allein lag die Number Needed to Test bei 3,6. Die Number Needed to Test zur Detektion eines klinisch relevanten Karzinoms betrug 13,7 f\u00fcr PI-RADS-3-L\u00e4sionen, 3,8 f\u00fcr PI-RADS-4-L\u00e4sionen und 1,7 f\u00fcr PI-RADS-5-L\u00e4sionen.<\/jats:p>\n                  <jats:p>L\u00e4sionen mit PI-RADS-Scores von 4 und 5 sollten konsequent biopsiert werden, w\u00e4hrend bei einem PI-RADS-Score von 3 durchaus eine individualisierte Abw\u00e4gung erforderlich sein kann, um beispielweise \u00dcberdiagnostik und unn\u00f6tige invasive Eingriffe zu vermeiden. Unsere Ergebnisse best\u00e4tigen die Empfehlungen der aktuellen Konsultationsfassung der S3-Leitlinie Prostatakarzinom (Version 8.01, AWMF-Registernummer: 043-022OL) und unterstreichen die klinische Relevanz eines risikoadaptierten diagnostischen Vorgehens.<\/jats:p>","DOI":"10.1055\/a-2707-3249","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:49:43Z","timestamp":1762904983000},"page":"487-493","source":"Crossref","is-referenced-by-count":0,"title":["Neue Prostatakarzinom-Leitlinie: Ist die Biopsie von PI-RADS-3-L\u00e4sionen sinnvoll? Stellenwert der multiparametrischen MRT-Fusionsbiopsie in der Detektion klinisch signifikanter Prostatakarzinome"],"prefix":"10.1055","volume":"57","author":[{"given":"Paul","family":"Schildhauer","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Schleswig-Holstein Campus L\u00fcbeck, Germany","place":["L\u00fcbeck"],"department":["Urologie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marten","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Schleswig-Holstein Campus L\u00fcbeck, Germany","place":["L\u00fcbeck"],"department":["Urologie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel S.","family":"Merseburger","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Schleswig-Holstein Campus L\u00fcbeck, Germany","place":["L\u00fcbeck"],"department":["Urologie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"F\u00fcrschke","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Schleswig-Holstein Campus L\u00fcbeck, Germany","place":["Lubeck"],"department":["Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannic","family":"Elser","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Schleswig-Holstein Campus L\u00fcbeck, Germany","place":["Lubeck"],"department":["Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Moderegger","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Schleswig-Holstein Campus L\u00fcbeck, Germany","place":["L\u00fcbeck"],"department":["Urologie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik Eike","family":"Fender","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Schleswig-Holstein Campus L\u00fcbeck, Germany","place":["L\u00fcbeck"],"department":["Urologie"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012663.pub2","article-title":"Prostate MRI, with or without MRI-targeted biopsy, and systematic biopsy for detecting prostate cancer","volume":"4","author":"F-JH Drost","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/jmri.27546","article-title":"Performance of Prostate Imaging Reporting and Data System Version 2.1 for Diagnosis of Prostate Cancer: A Systematic Review and Meta-Analysis","volume":"54","author":"KJ Park","year":"2021","journal-title":"J Magn Reson 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