{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:31Z","timestamp":1787004871394,"version":"build-2736575974"},"reference-count":78,"publisher":"Georg Thieme Verlag KG","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Innovationsfonds des Gemeinsamen\n                        Bundesausschusses","award":["Projekt-Nr. 01VSF21030"],"award-info":[{"award-number":["Projekt-Nr. 01VSF21030"]}]},{"name":"Else-Kr\u00f6ner-Fresenius-Stiftung","award":["022_EKEA.133"],"award-info":[{"award-number":["022_EKEA.133"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die Alzheimer-Krankheit (AD) z\u00e4hlt zu den h\u00e4ufigsten neurodegenerativen\n                        Erkrankungen im Alter. Menschen mit Down-Syndrom (DS) haben aufgrund der\n                        Trisomie 21 und der \u00dcberexpression des Amyloid Precursor Protein ein\n                        deutlich erh\u00f6htes Risiko f\u00fcr eine Demenz durch AD mit Pr\u00e4valenzen von bis zu\n                        88% jenseits des 65. Lebensjahres. Dennoch fehlen strukturierte Leitlinien\n                        zur Diagnostik und Therapie der Down-Syndrom-assoziierten Alzheimer-Demenz\n                        (DSAD).<\/jats:p>\n                  <jats:p>Es wurde eine narrative \u00dcbersicht der relevanten Literatur zu \u00c4tiologie,\n                        Diagnostik, Therapie und Versorgung bei DSAD erstellt. Zudem erfolgte eine\n                        Evaluation bestehender Standards der allgemeinen Demenzdiagnostik bzgl. der\n                        Besonderheiten bei Menschen mit DS.<\/jats:p>\n                  <jats:p>Etablierte diagnostische Verfahren sind auch bei Menschen mit DS anwendbar,\n                        m\u00fcssen jedoch hinsichtlich Symptomwahrnehmung, Testdurchf\u00fchrung und\n                        Befundinterpretation angepasst werden. Die Sensibilisierung von Angeh\u00f6rigen\n                        und Versorgern sowie die fr\u00fchzeitige Anbindung an spezialisierte Zentren\n                        sind entscheidend f\u00fcr eine zielgerichtete Diagnostik und Therapie.<\/jats:p>\n                  <jats:p>Eine verbesserte Versorgung von Menschen mit DSAD erfordert eine enge\n                        Kooperation zwischen Regelversorgung und spezialisierten Einrichtungen.\n                        Dieses Review gibt einen \u00dcberblick \u00fcber die medizinischen, diagnostischen\n                        und strukturellen Anforderungen bei Verdacht auf DSAD und leitet praxisnahe\n                        Handlungsempfehlungen f\u00fcr die Versorgung ab. Der abschlie\u00dfende Leitfaden\n                        soll somit helfen, bestehende Unsicherheiten in der Praxis zu reduzieren und\n                        eine langfristige, bedarfsgerechte Versorgung sicherzustellen.<\/jats:p>","DOI":"10.1055\/a-2708-3648","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T23:37:31Z","timestamp":1762385851000},"source":"Crossref","is-referenced-by-count":1,"title":["Ein Review und Leitfaden f\u00fcr die ad\u00e4quate und interdisziplin\u00e4re\n                    (sozial-)medizinische Versorgung von Menschen mit einem Down-Syndrom und einer\n                    dementiellen Entwicklung"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3211-9105","authenticated-orcid":false,"given":"Olivia","family":"Wagemann","sequence":"additional","affiliation":[{"name":"Neurologie, LMU Klinikum Neurologische Klinik und\n                    Poliklinik, M\u00fcnchen, Germany"},{"name":"DZNE, Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen Standort\n                    M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina A.","family":"Tesky","sequence":"additional","affiliation":[{"name":"Goethe-Universit\u00e4t Frankfurt am Main Institut f\u00fcr\n                    Allgemeinmedizin, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Schall","sequence":"additional","affiliation":[{"name":"Goethe-Universit\u00e4t Frankfurt am Main Institut f\u00fcr\n                    Allgemeinmedizin, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4492-7302","authenticated-orcid":false,"given":"Georg","family":"N\u00fcbling","sequence":"additional","affiliation":[{"name":"Neurologie, LMU Klinikum Neurologische Klinik und\n                    Poliklinik, M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Wlasich","sequence":"additional","affiliation":[{"name":"Neurologie, LMU Klinikum Neurologische Klinik und\n                    Poliklinik, M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"H\u00fcer","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Duisburg-Essen Lehrstuhl f\u00fcr\n                    Medizinmanagement, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Walendzik","sequence":"additional","affiliation":[{"name":"Essener Forschungsinstitut f\u00fcr Medizinmanagement GmbH,\n                    Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Weitzel","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Duisburg-Essen Lehrstuhl f\u00fcr\n                    Medizinmanagement, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godwin D.","family":"Giebel","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Duisburg-Essen Lehrstuhl f\u00fcr\n                    Medizinmanagement, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Raszke","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Duisburg-Essen Lehrstuhl f\u00fcr\n                    Medizinmanagement, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Wasem","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Duisburg-Essen Lehrstuhl f\u00fcr\n                    Medizinmanagement, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Pantel","sequence":"additional","affiliation":[{"name":"Goethe-Universit\u00e4t Frankfurt am Main Institut f\u00fcr\n                    Allgemeinmedizin, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[{"name":"Neurologie, LMU Klinikum Neurologische Klinik und\n                    Poliklinik, M\u00fcnchen, Germany"},{"name":"DZNE, Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen Standort\n                    M\u00fcnchen, Munich, Germany"},{"name":"SyNergy, Munich Cluster for Systems Neurology, Munich,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/s1474-4422(16)00063-6","article-title":"Dementia in Down\u2019s syndrome","volume":"15","author":"C Ballard","year":"2016","journal-title":"Lancet Neurol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1111\/jir.12390","article-title":"A prospective 20-year longitudinal 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