{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:05:23Z","timestamp":1788865523851,"version":"build-2803163510"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>The aim of this cross-sectional study was to compare and test associations\n                    between inflammatory profiles and liver steatosis\/fibrosis in individuals with\n                    different degrees of adiposity with or without metabolic syndrome. Forty-six\n                    patients (82.6% females, aged 38.3\u00b17.8 yr, body mass index of 32.6\u00b15.1\n                        kg\/m2) were allocated into three groups according to body\n                    adiposity and the presence or absence of metabolic syndrome: normal-weight\n                    controls, patients with obesity or with obesity and metabolic syndrome.\n                    Between-group comparisons were performed for clinical history, anthropometry,\n                    biochemical, metabolic, and inflammatory profiles, and degree of liver stiffness\n                    and steatosis by transient elastography. As expected, obesity and obesity and\n                    metabolic syndrome had greater body mass index and waist circumference than\n                    controls. No significant differences between groups in lipid profile, aspartate\n                    aminotransferase, ferritin, adiponectin, and retinol-binding protein-4 were\n                    noted. Obesity and metabolic syndrome had significantly higher fasting glucose\n                    levels compared to controls and obesity. A more significant proportion of\n                    patients with hypertension, higher insulinemia, HOMA-IR, glycated hemoglobin,\n                    aspartate aminotransferase, gamma-glutamyltransferase, tumor necrosis\n                    factor-alpha, interleukin-6, and leptin were observed in obesity and metabolic\n                    syndrome compared to controls. Obesity had higher alkaline phosphatase,\n                    interleukin-6, and leptin levels than controls. Liver stiffness and steatosis\n                    were higher in obesity and metabolic syndrome than in controls, while hepatic\n                    fibrosis degree F2 occurred more frequently in obesity and metabolic syndrome\n                        (p\u22640.03). No associations were detected between liver stiffness and\n                    steatosis and inflammatory biomarkers in the studied groups (p\u22650.07). Our\n                    findings highlight the impact of metabolic conditions on liver health but also\n                    suggest that systemic inflammation might not be directly linked to liver\n                    stiffness and steatosis.<\/jats:p>","DOI":"10.1055\/a-2712-8064","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T22:46:49Z","timestamp":1760741209000},"page":"529-534","source":"Crossref","is-referenced-by-count":1,"title":["Associations Between Inflammatory Adipokines, Liver Steatosis, and\n                    Fibrosis in Patients with Different Degrees of Adiposity with or Without\n                    Metabolic Syndrome"],"prefix":"10.1055","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3005-3889","authenticated-orcid":false,"given":"Karynne Grutter","family":"Lopes","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Clinical and Experimental\n                    Physiopathology (Fisclinex), Faculty of Medical Sciences, State University of\n                    Rio de Janeiro, Rio de Janeiro, RJ, Brazil"},{"name":"Laboratory for Clinical and Experimental Research on\n                    Vascular Biology (Biovasc), Biomedical Center, State University of Rio de\n                    Janeiro, Rio de Janeiro, RJ, Brazil"},{"name":"Obesity Unit, Multiuser Clinical Research Center\n                    (CePeM), Pedro Ernesto University Hospital (HUPE), State University of Rio de\n                    Janeiro, RJ, Brazil"},{"name":"Department of Physiological Sciences, Roberto Alcantara\n                    Gomes Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ,\n                    Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5512-2871","authenticated-orcid":false,"given":"Maria das Gra\u00e7as Coelho de","family":"Souza","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Clinical and Experimental\n                    Physiopathology (Fisclinex), Faculty of Medical Sciences, State University of\n                    Rio de Janeiro, Rio de Janeiro, RJ, Brazil"},{"name":"Laboratory for Clinical and Experimental Research on\n                    Vascular Biology (Biovasc), Biomedical Center, State University of Rio de\n                    Janeiro, Rio de Janeiro, RJ, Brazil"},{"name":"Obesity Unit, Multiuser Clinical Research Center\n                    (CePeM), Pedro Ernesto University Hospital (HUPE), State University of Rio de\n                    Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9092-321X","authenticated-orcid":false,"given":"Fernanda de Azevedo Marques","family":"Lopes","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Clinical and Experimental\n                    Physiopathology (Fisclinex), Faculty of Medical Sciences, State University of\n                    Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4958-898X","authenticated-orcid":false,"given":"Vicente Lopes","family":"da Silva Junior","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Clinical and Experimental\n                    Physiopathology (Fisclinex), Faculty of Medical Sciences, State University of\n                    Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3069-128X","authenticated-orcid":false,"given":"Carlos Antonio","family":"Terra","sequence":"additional","affiliation":[{"name":"Gastroenterology, Department of Internal Medicine,\n                    Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro,\n                    RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1127-0394","authenticated-orcid":false,"given":"Ana Teresa Pugas","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Gastroenterology, Department of Internal Medicine,\n                    Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro,\n                    RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9621-8252","authenticated-orcid":false,"given":"Eliete","family":"Bouskela","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Clinical and Experimental\n                    Physiopathology (Fisclinex), Faculty of Medical Sciences, State University of\n                    Rio de Janeiro, Rio de Janeiro, RJ, Brazil"},{"name":"Laboratory for Clinical and Experimental Research on\n                    Vascular Biology (Biovasc), Biomedical Center, State University of Rio de\n                    Janeiro, Rio de Janeiro, RJ, Brazil"},{"name":"Obesity Unit, Multiuser Clinical Research Center\n                    (CePeM), Pedro Ernesto University Hospital (HUPE), State University of Rio de\n                    Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3528-5881","authenticated-orcid":false,"given":"Luiz Guilherme","family":"Kraemer-Aguiar","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Clinical and Experimental\n                    Physiopathology (Fisclinex), Faculty of Medical Sciences, State University of\n                    Rio de Janeiro, Rio de Janeiro, RJ, Brazil"},{"name":"Laboratory for Clinical and Experimental Research on\n                    Vascular Biology (Biovasc), Biomedical Center, State University of Rio de\n                    Janeiro, Rio de Janeiro, RJ, Brazil"},{"name":"Obesity Unit, Multiuser Clinical Research Center\n                    (CePeM), Pedro Ernesto University Hospital (HUPE), State University of Rio de\n                    Janeiro, RJ, Brazil"},{"name":"Endocrinology, Department of Internal Medicine, Faculty\n                    of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, RJ,\n                    Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"ref3","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41574-019-0176-8","article-title":"Obesity: global epidemiology and pathogenesis","volume":"15","author":"M. 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