{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T23:55:06Z","timestamp":1764374106072,"version":"3.46.0"},"reference-count":57,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Bei einer 6-j\u00e4hrigen Lagotto Romagnolo-H\u00fcndin aus Deutschland wurde im Rahmen\n                    einer Vorsorgeuntersuchung in der sonografischen Untersuchung des Abdomens eine\n                    Splenomegalie mit diffusem, heterogenem Parenchym festgestellt. Die zytologische\n                    Untersuchung eines Milzaspirates ergab eine reaktive lymphoide Hyperplasie und\n                    extramedull\u00e4re H\u00e4matopoese. Im Laufe der weiterf\u00fchrenden Aufarbeitung konnte\n                    eine Babesiose mit hohem Babesia-Antik\u00f6rperspiegel und dem Nachweis von\n                        Babesia canis als Ursache der parenchymalen Milzver\u00e4nderungen\n                    diagnostiziert werden. Zu keiner Zeit zeigte die H\u00fcndin eine klinische\n                    Symptomatik oder labordiagnostische Auff\u00e4lligkeit im Rahmen ihrer Erkrankung,\n                    obwohl eine aktive Babesiose diagnostiziert wurde. Aufgrund des hohen\n                    Antik\u00f6rperspiegels kann ein bereits zu einem fr\u00fcheren Zeitpunkt stattgefundener\n                    Erregerkontakt oder ein subakuter Verlauf postuliert werden.<\/jats:p>\n                  <jats:p>Dies ist, soweit den Autoren bekannt ist, eine der wenigen Beschreibungen einer\n                    Babesiose mit einer strukturellen Splenopathie mit nachgewiesener\n                    extramedull\u00e4rer H\u00e4matopoese als einziger Hinweis auf das Vorliegen der\n                    Infektionserkrankung ohne entsprechende h\u00e4matologische Befunde.<\/jats:p>","DOI":"10.1055\/a-2712-8982","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T23:50:07Z","timestamp":1764373807000},"page":"362-371","source":"Crossref","is-referenced-by-count":0,"title":["Splenopathie bei einer autochthon mit Babesia canis\n                    infizierten H\u00fcndin aus Deutschland ohne klinische und h\u00e4matologische\n                    Auff\u00e4lligkeiten"],"prefix":"10.1055","volume":"53","author":[{"given":"Alina","family":"Kanstinger","sequence":"additional","affiliation":[{"name":"Kleintierklinik Ettlingen, Ettlingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Dinkel","sequence":"additional","affiliation":[{"name":"Kleintierklinik Ettlingen, Ettlingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"von Magnis","sequence":"additional","affiliation":[{"name":"Kleintierzentrum Iffezheim, Iffezheim"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothee","family":"Dahlem","sequence":"additional","affiliation":[{"name":"Kleintierklinik Ettlingen, Ettlingen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1186\/s13071-023-06005-7","article-title":"Molecular detection of Babesia spp. in dogs in Germany (2007\u20132020) and\n                    identification of potential risk factors for infection","volume":"16","author":"I Sch\u00e4fer","year":"2023","journal-title":"Parasit Vectors"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/jvim.16611","article-title":"Autochthonous Babesia canis infections in 49 dogs in Germany","volume":"37","author":"C Weingart","year":"2023","journal-title":"J Vet Intern Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1055\/a-1704-6604","article-title":"Vorkommen von kaniner Babesiose bei Hunden im Rhein-Main-Gebiet in Hessen \u2013 eine\n                    Fallstudie mit 81 Hunden","volume":"50","author":"S Seibert","year":"2022","journal-title":"Tier\u00e4rztl Prax Ausg K Kleintiere Heimtiere"},{"key":"ref4","first-page":"119","article-title":"Canine babesiosis: a perspective on clinical complications, biomarkers, and\n                    treatment","volume":"6","author":"L S K\u00f6ster","year":"2015","journal-title":"Vet Med Res Rep"},{"key":"ref5","first-page":"100471","article-title":"Global distribution of canine Babesia species identified by a commercial\n                    diagnostic laboratory","volume":"22","author":"A J Birkenheuer","year":"2020","journal-title":"Vet Parasitol Reg Stud Rep"},{"key":"ref6","volume-title":"Protozoa. In: Lehrbuch der Parasitologie f\u00fcr die Tiermedizin. 3. Auflage","author":"P Deplazes","year":"2013"},{"key":"ref8","first-page":"107","article-title":"Einige seltene Zeckenfunde im mittleren Teil der DDR","volume":"5","author":"V P Negrobov","year":"1964","journal-title":"Angew Parasitol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ijmm.2006.01.013","article-title":"Evidence for an increased geographical distribution of Dermacentor\n                        reticulatus in Germany and detection of Rickettsia sp","volume":"296","author":"H Dautel","year":"2006","journal-title":"Int J Med Microbiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/BF00260280","article-title":"Zum Vorkommen der Zecke Dermacentor pictus (Herm. 1804) in\n                    Deutschland","volume":"18","author":"K Enigk","year":"1958","journal-title":"Z F\u00fcr Parasitenkd"},{"key":"ref11","first-page":"116","article-title":"Babesia canis and Dermacentor reticulatus in Munich: a new endemic\n                    focus in Germany","volume":"28","author":"M Zahler","year":"2000","journal-title":"Tierarztl Prax Ausg K Kleintiere Heimtiere"},{"key":"ref12","first-page":"170","article-title":"Babesiosis of dogs in Germany: epidemiologic case analysis","volume":"19","author":"R Gothe","year":"1991","journal-title":"Tierarztl Prax"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"578220","DOI":"10.3389\/fvets.2020.578220","article-title":"The Spatial Distribution of Dermacentor Ticks (Ixodidae) in\n                    Germany\u2013Evidence of a Continuing Spread of Dermacentor reticulatus","volume":"7","author":"M Drehmann","year":"2020","journal-title":"Front Vet Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1044597","DOI":"10.3389\/fvets.2022.1044597","article-title":"Update and prognosis of Dermacentor distribution in Germany: Nationwide\n                    occurrence of Dermacentor reticulatus","volume":"9","author":"A Springer","year":"2022","journal-title":"Front Vet Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/s13071-016-1599-x","article-title":"Dermacentor reticulatus: a vector on the rise","volume":"9","author":"G F\u00f6ldv\u00e1ri","year":"2016","journal-title":"Parasit Vectors"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"500","DOI":"10.5604\/12321966.1120590","article-title":"The first evidence for vertical transmission of Babesia canis in a litter\n                    of Central Asian Shepherd dogs","volume":"21","author":"E Mierzejewska","year":"2014","journal-title":"Ann Agric Environ Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"959","DOI":"10.2460\/javma.2003.222.959","article-title":"Transfusion-associated Babesia gibsoni infection in a dog","volume":"222","author":"J R Stegeman","year":"2003","journal-title":"J Am Vet Med Assoc"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.vetpar.2011.04.023","article-title":"Babesiosis in dogs and cats\u2013Expanding parasitological and clinical spectra","volume":"181","author":"L Solano-Gallego","year":"2011","journal-title":"Vet Parasitol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1756-3305-2-S1-S4","article-title":"Canine babesiosis: from molecular taxonomy to control","volume":"2","author":"P J Irwin","year":"2009","journal-title":"Parasit Vectors"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1751-0813.1991.tb03194.x","article-title":"Clinical and pathological findings of Babesia infection in dogs","volume":"68","author":"P J Irwin","year":"1991","journal-title":"Aust Vet J"},{"key":"ref21","first-page":"V03","article-title":"H\u00e4matologische Befunde bei mit Babesia canis infizierten Hunden in\n                    Deutschland (2018\u20132024)","volume":"53","author":"C Eisenecker","year":"2025","journal-title":"Tier\u00e4rztl Prax Ausg K Kleintiere Heimtiere"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.vetpar.2015.05.028","article-title":"Classification of Babesia canis strains in Europe based on polymorphism\n                    of the Bc28.1-gene from the Babesia canis Bc28 multigene family","volume":"211","author":"B Carcy","year":"2015","journal-title":"Vet Parasitol"},{"key":"ref23","first-page":"310","article-title":"Canine haemobartonellosis and babesiosis","volume":"23","author":"A C Kraje","year":"2001","journal-title":"Compend Contin Educ Pract Vet"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.vetpar.2008.07.024","article-title":"Babesia canis canis and Babesia canis vogeli clinicopathological\n                    findings and DNA detection by means of PCR-RFLP in blood from Italian dogs\n                    suspected of tick-borne disease","volume":"157","author":"L Solano-Gallego","year":"2008","journal-title":"Vet Parasitol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.vetpar.2006.01.046","article-title":"Canine babesiosis in France","volume":"138","author":"G Bourdoiseau","year":"2006","journal-title":"Vet Parasitol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.vetpar.2005.07.016","article-title":"Clinicopathological findings in naturally occurring cases of babesiosis caused\n                    by large form Babesia from dogs of northeastern Italy","volume":"134","author":"T Furlanello","year":"2005","journal-title":"Vet Parasitol"},{"key":"ref27","first-page":"P02","article-title":"Blutbefunde bei Hunden mit akuter Babesia canis Infektion im Verlauf der\n                    Therapie","volume":"53","author":"I von Hohnhorst","year":"2025","journal-title":"Tier\u00e4rztl Prax Ausg K Kleintiere Heimtiere"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1186\/s13071-025-06997-4","article-title":"Impact of levels of parasitemia and antibodies, acute-phase proteins, as well as\n                    stays abroad on hematological and biochemical parameters in 342 dogs with acute\n                        Babesia canis infection","volume":"18","author":"I von Hohnhorst","year":"2025","journal-title":"Parasit Vectors"},{"key":"ref29","first-page":"17","article-title":"Babesia canis infection in a splenectomized dog","volume":"95","author":"A T Camacho","year":"2002","journal-title":"Bull Soc Pathol Exot 1990"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13028-016-0189-4","article-title":"Fatal Babesia canis canis infection in a splenectomized Estonian dog","volume":"58","author":"V Ti\u0161kina","year":"2016","journal-title":"Acta Vet Scand"},{"key":"ref31","doi-asserted-by":"crossref","DOI":"10.1002\/9781119500537.ch51","volume-title":"Structure, Function, and Disorders of Lymphoid Tissue. In: Brooks MB, Harr KE,\n                    Seelig DM, Wardrop KJ, Weiss DJ, Herausgeber. Schalm\u2019s Veterinary Hematology.\n                    7th Edition","author":"A L Warren","year":"2022"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nri1669","article-title":"Structure and function of the spleen","volume":"5","author":"R E Mebius","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref33","volume-title":"The Hematopoietic System. In: Brooks MB, Harr KE, Seelig DM, Wardrop KJ, Weiss\n                    DJ, Herausgeber. Schalm\u2019s Veterinary Hematology. 7th Edition","author":"B D Car","year":"2022"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1556\/avet.54.2006.3.7","article-title":"Clinical manifestations of canine babesiosis in Hungary (63 cases)","volume":"54","author":"A M\u00e1th\u00e9","year":"2006","journal-title":"Acta Vet Hung"},{"key":"ref35","volume-title":"Babesiosis. In: Greene CE, Herausgeber. Clinical microbiology and infectious\n                    diseases ot the dog and cat","author":"E B Breitschwerdt","year":"1984"},{"key":"ref36","volume-title":"Babesiosis. In: Sykes JE, Herausgeber. Greene\u2019s Infectious Diseses of the Dog\n                    and Cat. Fifth Edition","author":"A J Birkenheuer","year":"2023"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e00186","DOI":"10.1016\/j.parepi.2020.e00186","article-title":"Prevalence of canine babesiosis and their risk factors among asymptomatic dogs\n                    in the federal capital territory, Abuja, Nigeria","volume":"11","author":"S S Obeta","year":"2020","journal-title":"Parasite Epidemiol Control"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"211","DOI":"10.19182\/remvt.8835","article-title":"Prevalence of antibodies against Babesia canis in dogs in an endemic\n                    area","volume":"42","author":"P A Bobade","year":"1989","journal-title":"Rev D\u2019\u00e9levage M\u00e9decine V\u00e9t Pays Trop"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1186\/s13071-016-1596-0","article-title":"A review of canine babesiosis: the European perspective","volume":"9","author":"L Solano-Gallego","year":"2016","journal-title":"Parasit Vectors"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2460\/javma.1994.204.01.94","article-title":"Hypotensive shock syndrome associated with acute Babesia canis infection\n                    in a dog","volume":"204","author":"M J Freeman","year":"1994","journal-title":"J Am Vet Med Assoc"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e1003387","DOI":"10.1371\/journal.ppat.1003387","article-title":"Babesia: an emerging infectious threat in transfusion medicine","volume":"9","author":"C A Lobo","year":"2013","journal-title":"PLoS Pathog"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/jvim.13823","article-title":"Update on Canine and Feline Blood Donor Screening for Blood-Borne Pathogens","volume":"30","author":"K J Wardrop","year":"2016","journal-title":"J Vet Intern Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"109140","DOI":"10.1016\/j.vetpar.2020.109140","article-title":"Evidence of acute phase reaction in asymptomatic dogs naturally infected with\n                        Babesia canis","volume":"282","author":"Z Milanovi\u0107","year":"2020","journal-title":"Vet Parasitol"},{"key":"ref44","volume-title":"Diseases of the Spleen. In: C\u00f4t\u00e9 E, Ettinger SJ, Feldman EC, Herausgeber.\n                    Ettinger\u2019s Textbook of Veterniary Internal Medicine. Ninth Edition","author":"T A Donovan","year":"2024"},{"key":"ref45","volume-title":"Spleen. In: Pennick D, d\u2019Anjou MA, Herausgeber. Atlas of Small Animal\n                    Ultrasonography. Second Edition","author":"S Hecht","year":"2008"},{"key":"ref46","first-page":"2612","article-title":"Canine Babesiosis Caused by Large Babesia Species: Global Prevalence and\n                    Risk Factors-A Review","volume":"13","author":"W Zygner","year":"2023","journal-title":"Anim Open Access J MDPI"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3390\/parasitologia3010008","article-title":"Case Report of a Fatal Babesia vulpes Infection in a Splenectomised\n                    Dog","volume":"3","author":"M S Unterk\u00f6fler","year":"2023","journal-title":"Parasitologia"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"110032","DOI":"10.1016\/j.vetpar.2023.110032","article-title":"Experimental infection and co-infection with Chinese strains of Ehrlichia\n                        canis and Babesia vogeli in intact and splenectomized dogs:\n                    Insights on clinical, hematologic and treatment responses","volume":"323","author":"J Zhang","year":"2023","journal-title":"Vet Parasitol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1089\/sur.2008.001","article-title":"Babesiosis in the immediate postoperative period after splenectomy for\n                    trauma","volume":"10","author":"M E Semel","year":"2009","journal-title":"Surg Infect"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1740-8261.2010.01775.x","article-title":"Abdominal Ultrasonographic Findings in Dogs Naturally Infected with\n                    Babesiosis","volume":"52","author":"E Fraga","year":"2011","journal-title":"Vet Radiol Ultrasound"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s12639-014-0485-8","article-title":"Ultrasonographic changes in dogs naturally infected with tick borne\n                    intracellular diseases","volume":"40","author":"K Sarma","year":"2016","journal-title":"J Parasit Dis"},{"key":"ref52","volume-title":"Milz. In: du Plessis WM, Herausgeber. Sono-Grundkurs f\u00fcr Tiermediziner\n                    Ultraschalldiagnostik bei Hund und Katze \u2013 verstehen, erkennen, interpretieren.\n                    1. Auflage","author":"SAE B Boroffka","year":"2013"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.vetimm.2016.10.008","article-title":"Optimisation and validation of a PCR for antigen receptor rearrangement (PARR)\n                    assay to detect clonality in canine lymphoid malignancies","volume":"182","author":"E M Waugh","year":"2016","journal-title":"Vet Immunol Immunopathol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1292\/jvms.001673","article-title":"Sensitivity for the Detection of a Clonally Rearranged Antigen Receptor Gene in\n                    Endoscopically Obtained Biopsy Specimens from Canine Alimentary Lymphoma","volume":"71","author":"K Fukushima","year":"2009","journal-title":"J Vet Med Sci"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4322\/rbpv.01803007","article-title":"Comparison between a soluble antigen-based ELISA and IFAT in detecting\n                    antibodies against Babesia canis in dogs","volume":"18","year":"2009","journal-title":"Rev Bras Parasitol Veterin\u00e1ria"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"110197","DOI":"10.1016\/j.vetpar.2024.110197","article-title":"Age, sex and breed effect on laboratory parameters in natural Babesia\n                        canis infection","volume":"329","author":"F Janji\u0107","year":"2024","journal-title":"Vet Parasitol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1186\/s12917-019-2181-5","article-title":"A novel PCR-based point-of-care method enables rapid, sensitive and reliable\n                    diagnosis of Babesia gibsoni infection in dogs","volume":"15","author":"I L Liu","year":"2019","journal-title":"BMC Vet Res"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"101362","DOI":"10.1016\/j.ttbdis.2019.101362","article-title":"Rapid identification of Babesia canis and Babesia gibsoni (Asian\n                    genotype) in canine blood samples using a customized portable real-time PCR\n                    analyzer and TaqMan-based assay","volume":"11","author":"C Y Kuo","year":"2020","journal-title":"Ticks Tick-Borne Dis"}],"container-title":["Tier\u00e4rztliche Praxis Ausgabe K: Kleintiere \/ Heimtiere"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2712-8982.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T23:50:28Z","timestamp":1764373828000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2712-8982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":57,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2025,11,28]]},"published-print":{"date-parts":[[2025,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2712-8982","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1434-1239","2567-5842"],"issn-type":[{"value":"1434-1239","type":"print"},{"value":"2567-5842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,28]]}}}