{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T23:46:29Z","timestamp":1765410389247,"version":"3.46.0"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"01\/02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die Antiaggregation mit Thrombozytenfunktionshemmern (TFH) ist fester Bestandteil in der Sekund\u00e4rpr\u00e4vention bei Patienten mit manifesten atherosklerotischen Gef\u00e4\u00dferkrankungen. Die Rolle von TFH in der Prim\u00e4rpr\u00e4vention ist umstritten. Die Leitlinien zur peripheren arteriellen Verschlusskrankheit (PAVK) und zur Carotisstenose empfehlen, dass Patienten, die klinisch asymptomatisch sind, keine TFH einnehmen sollen. Die Datenlage, die dieser Entscheidung zu Grunde liegt, hat jedoch einen niedrigen Evidenzgrad und andere internationale Leitlinien empfehlen die Gabe von TFH bei allen Patienten mit Nachweis von Plaques in der Carotis.<\/jats:p>\n                  <jats:p>Die vorliegende Analyse der Literatur zeigt, dass die pauschale Aussage, dass Patienten mit asymptomatischer Atherosklerose der Carotis (Stenosegrad &lt;50%) und pAVK keine prophylaktische TFH ben\u00f6tigen, weder das Ausma\u00df noch die Morphologie der Atherosklerose ber\u00fccksichtigt. Die Indikation zur TFH-Gabe bei asymptomatischer Atherosklerose sollte stets individuell gestellt werden und dabei sowohl das Ausma\u00df der Atherosklerose als auch das pers\u00f6nliche Blutungs- und Isch\u00e4mierisiko einbeziehen.<\/jats:p>","DOI":"10.1055\/a-2712-9785","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T23:43:29Z","timestamp":1765410209000},"page":"41-46","source":"Crossref","is-referenced-by-count":0,"title":["Ist die Antiaggregation mit Thrombozytenfunktionshemmern bei asymptomatischen atherosklerotischen Plaques zur Prophylaxe indiziert?"],"prefix":"10.1055","volume":"151","author":[{"given":"Siamak","family":"Pourhassan","sequence":"additional","affiliation":[{"name":"Gemeinschaftspraxis f\u00fcr Gef\u00e4\u00dfmedizin und Gef\u00e4\u00dfchirurgie, POST-Praxen, Oberhausen,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitriy","family":"Dovzhanskiy","sequence":"additional","affiliation":[{"name":"Praxis f\u00fcr Gef\u00e4\u00dfchirurgie Bensheim, Venenzentrum Bergstra\u00dfe und Darmstadt,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Voshege","sequence":"additional","affiliation":[{"name":"Facharztzentrum Niederrhein, Dinslaken,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Gregor","sequence":"additional","affiliation":[{"name":"Gef\u00e4\u00dfmedizinische Schwerpunktpraxis, D\u00fcsseldorf,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Knauf","sequence":"additional","affiliation":[{"name":"Gef\u00e4\u00dfzentrum Gef\u00e4\u00df und Orthop\u00e4die Zentrum, Augsburg,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knut","family":"Kroeger","sequence":"additional","affiliation":[{"name":"HELIOS Klinikum Krefeld, Krefeld, GERMANY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1136\/bmj.324.7329.71","article-title":"Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high-risk patients","volume":"324","author":"Antithrombotic Trialists\u02bc Collaboration","year":"2002","journal-title":"BMJ"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1093\/eurheartj\/ehab484","article-title":"2021 ESC Guidelines on cardiovascular disease prevention in clinical practice","volume":"42","author":"FLJ Visseren","year":"2021","journal-title":"Eur Heart J"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1159\/000343145","article-title":"Mannheim carotid intima-media thickness and plaque consensus (2004\u20132006\u20132011). 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