{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T14:43:30Z","timestamp":1769697810163,"version":"3.49.0"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Systemic immune-inflammatory indices derived from routine complete blood counts\n                    are useful markers of systemic inflammation across various conditions.\n                    Currently, double filtration plasmapheresis is used to lower lipid levels and\n                    remove pro-inflammatory mediators; however, its effects on systemic\n                    immune-inflammatory indices are underreported. A retrospective analysis of\n                    patients undergoing two double filtration plasmapheresis sessions for\n                    hypercholesterolemia or hyperlipoproteinemia(a) at a single center was conducted\n                    between April and July 2025. Complete blood count-derived immune-inflammatory\n                    indices and lipid profiles were measured immediately before and after the first\n                    and second double filtration plasmapheresis sessions, respectively.\n                    Intra-individual comparisons were performed using the Wilcoxon signed-rank test.\n                    Double filtration plasmapheresis performed with the Inuspheresis System\n                    significantly reduced the neutrophil-to-lymphocyte ratio (p=0.040),\n                    platelet-to-lymphocyte ratio (p=&lt;0.001), systemic immune-inflammatory\n                    index (p=0.008), and aggregate index of systemic inflammation\n                    (p=0.048), while significantly increasing lymphocyte-to-monocyte ratio\n                        (p=&lt;0.001); systemic inflammation response index did not change\n                    significantly. Expected reductions were also observed in total cholesterol, LDL\n                    cholesterol, HDL cholesterol, triglycerides, and lipoprotein(a), all with\n                        p &lt;0.001. In addition to its lipid-lowering effects, double\n                    filtration plasmapheresis modulated short-term systemic immune-inflammatory\n                    indices, indicating potential utility for these metrics as surrogate markers of\n                    acute systemic inflammation and immunomodulation. Given their availability from\n                    routine complete blood counts, monitoring these indices could aid individualized\n                    patient assessment during double filtration plasmapheresis. These results may\n                    also help refine personalized care in patients with low-grade inflammation and\n                    aging-related immune dysfunction.<\/jats:p>","DOI":"10.1055\/a-2715-1126","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T23:44:22Z","timestamp":1763163862000},"page":"639-645","source":"Crossref","is-referenced-by-count":1,"title":["Modulating Systemic Immune-Inflammatory Indices via Double Filtration\n                    Plasmapheresis: Implications for Aging and Low-Grade\n                    Inflammation"],"prefix":"10.1055","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8169-9914","authenticated-orcid":false,"given":"Yandy Marx","family":"Castillo-Aleman","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC), Abu Dhabi, United\n                    Arab Emirates"},{"name":"Yas Clinic Khalifa City (YCKC) Hospital, Abu Dhabi,\n                    United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Agustin","family":"Villegas-Valverde","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC), Abu Dhabi, United\n                    Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yendry","family":"Ventura-Carmenate","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC), Abu Dhabi, United\n                    Arab Emirates"},{"name":"Yas Clinic Khalifa City (YCKC) Hospital, Abu Dhabi,\n                    United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maysoon","family":"Al-Karam","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC), Abu Dhabi, United\n                    Arab Emirates"},{"name":"Yas Clinic Khalifa City (YCKC) Hospital, Abu Dhabi,\n                    United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwag Shamkhi","family":"Al Dhuhaibat","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC), Abu Dhabi, United\n                    Arab Emirates"},{"name":"Yas Clinic Khalifa City (YCKC) Hospital, Abu Dhabi,\n                    United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinnette","family":"Lumame","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC), Abu Dhabi, United\n                    Arab Emirates"},{"name":"Yas Clinic Khalifa City (YCKC) Hospital, Abu Dhabi,\n                    United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay Mary","family":"Rose-Roque","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC), Abu Dhabi, United\n                    Arab Emirates"},{"name":"Yas Clinic Khalifa City (YCKC) Hospital, Abu Dhabi,\n                    United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charisma","family":"Castelo","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC), Abu Dhabi, United\n                    Arab Emirates"},{"name":"Yas Clinic Khalifa City (YCKC) Hospital, Abu Dhabi,\n                    United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Benedetti","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC), Abu Dhabi, United\n                    Arab Emirates"},{"name":"Yas Clinic Khalifa City (YCKC) Hospital, Abu Dhabi,\n                    United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatema Mohammed","family":"Al-Kaabi","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC), Abu Dhabi, United\n                    Arab Emirates"},{"name":"Yas Clinic Khalifa City (YCKC) Hospital, Abu Dhabi,\n                    United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene Antonio","family":"Rivero-Jimenez","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC), Abu Dhabi, United\n                    Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Alfonso","family":"Bencomo-Hernandez","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC), Abu Dhabi, United\n                    Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan R.","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC), Abu Dhabi, United\n                    Arab Emirates"},{"name":"Yas Clinic Khalifa City (YCKC) Hospital, Abu Dhabi,\n                    United Arab 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Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2715-1126.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T23:46:10Z","timestamp":1763768770000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2715-1126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":30,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,21]]},"published-print":{"date-parts":[[2025,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2715-1126","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]}}}