{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T23:24:33Z","timestamp":1787095473658,"version":"build-2736575974"},"reference-count":61,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Respir Crit Care Med"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pulmonary alveolar microlithiasis (PAM) has been well characterized in terms of its description, genetic background, and diagnostic process for decades; however, no effective prevention or treatment has yet been established. PAM is classified as an ultrarare lung disease linked to mutations in the autosomal recessive sodium\u2013phosphate co-transporter gene SLC34A2, which may serve as a potential target for future therapies. As new variants of SLC34A2 mutations continue to be identified, a broader genetic understanding could help predict the variable clinical course among patients and guide the development of therapies beyond palliative care. The creation of a disease severity score would be valuable for assessing disease burden, stratifying patients, and designing research studies. Given the clinico-radiological dissociation and heterogeneity of PAM, such a score should be developed as a composite index. Coupled with objective severity measures and identification of factors underlying individual variability, this approach could enhance insight into preventive and therapeutic strategies. Clinical advances in PAM remain limited, underscoring the need for international registries and cohorts as an urgent priority. Systematic re-evaluation of diagnosed cases and structured follow-up, rather than arbitrary visits, would generate standardized data critical for future research. A standardized patient evaluation form may facilitate the collection of data in a shared database.<\/jats:p>","DOI":"10.1055\/a-2716-4930","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T23:37:22Z","timestamp":1761781042000},"page":"396-408","source":"Crossref","is-referenced-by-count":1,"title":["Pulmonary Alveolar Microlithiasis: A Review of a Rare Disease Through Rarely Discussed Perspectives"],"prefix":"10.1055","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6869-1301","authenticated-orcid":false,"given":"G\u00f6ksel","family":"Alt\u0131n\u0131\u015f\u0131k","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Faculty of Medicine, Pamukkale University, Denizli, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-6461","authenticated-orcid":false,"given":"Nil\u00fcfer","family":"Yi\u011fit","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Faculty of Medicine, Pamukkale University, Denizli, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9077-0580","authenticated-orcid":false,"given":"Nazl\u0131","family":"\u00c7etin","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Afyonkarahisar State Hospital, Afyonkarahisar, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"issue":"158","key":"ref1","doi-asserted-by":"crossref","first-page":"200024","DOI":"10.1183\/16000617.0024-2020","article-title":"Pulmonary alveolar microlithiasis","volume":"29","author":"P Kosciuk","year":"2020","journal-title":"Eur Respir Rev"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1055\/s-0040-1702211","article-title":"Pulmonary alveolar microlithiasis","volume":"41","author":"B M Shaw","year":"2020","journal-title":"Semin Respir Crit Care Med"},{"issue":"138","key":"ref3","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1183\/16000617.0036-2015","article-title":"Pulmonary alveolar microlithiasis: review of the 1022 cases reported worldwide","volume":"24","author":"G Castellana","year":"2015","journal-title":"Eur Respir Rev"},{"key":"ref4","volume-title":"Manoscritti, vol. 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