{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T23:43:34Z","timestamp":1776210214790,"version":"3.50.1"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Handchir Mikrochir Plast Chir"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Amyloidosen sind seltene, meist systemische Erkrankungen, die bei kardialer\nBeteiligung zu einer progredienten Herzinsuffizienz f\u00fchren k\u00f6nnen. Die beiden\nh\u00e4ufigsten Subtypen mit kardialer Beteiligung \u2013 AL- und ATTR-Amyloidose \u2013\nunterscheiden sich grundlegend in Diagnostik, Therapie und Prognose.\nRetrospektive Studien zeigen, dass muskuloskelettale Manifestationen wie das\nKarpaltunnelsyndrom, die Tendovaginitis stenosans, Morbus Dupuytren oder\nSehnenrupturen h\u00e4ufig bereits Jahre vor der Diagnose einer kardialen Amyloidose\nauftreten und potenziell als fr\u00fche klinische Marker dienen k\u00f6nnen. Die\nrisikoadaptierte gezielte histopathologische Abkl\u00e4rung, kombiniert mit einer\nstrukturierten interdisziplin\u00e4ren Weiterbehandlung kann wesentlich zur\nfr\u00fchzeitigen Erkennung bislang unentdeckter systemischer Amyloidosen beitragen.\nDiese \u00dcbersichtsarbeit hebt die zunehmende Bedeutung muskuloskelettaler\nManifestationen im handchirurgischen Kontext als m\u00f6gliche Fr\u00fchzeichen\nsystemischer Amyloidosen hervor und schl\u00e4gt einen strukturierten Handlungspfad\nf\u00fcr die interdisziplin\u00e4re Zusammenarbeit mit Kardiologie und H\u00e4matologie\nvor.<\/jats:p>","DOI":"10.1055\/a-2716-7046","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T23:59:11Z","timestamp":1763423951000},"page":"119-126","source":"Crossref","is-referenced-by-count":0,"title":["Amyloidose aus kardiologischer Sicht \u2013 Welche kardiologische\nDiagnostik ist bei positivem Nachweis von Amyloid in extrakardialem Gewebe zur\nFr\u00fcherkennung einer Systemerkrankung sinnvoll?"],"prefix":"10.1055","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5954-5695","authenticated-orcid":false,"given":"St\u00e9phanie Kristina","family":"Schwarting","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I, Klinikum der Universit\u00e4t M\u00fcnchen,\nMunich, Germany"},{"name":"Klinik f\u00fcr Kardiologie, Angiologie und Pulmologie, Universit\u00e4tsKlinikum\nHeidelberg, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Massberg","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I, Klinikum der Universit\u00e4t M\u00fcnchen,\nMunich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Aus dem Siepen","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie, Angiologie und Pulmologie, Universit\u00e4tsKlinikum\nHeidelberg, Heidelberg, 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